公开(公告)号：UA99343C2

公开(公告)日：2012-08-10

申请号：UAA201011557

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： MULLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNG-MING ,  BARDWELL PHILLIP D

IPC: C07K16/22 ,  A61K39/395

Abstract: Изобретениеотноситсяк моноклональнымантителам, которыеимеютспособностьдетектироватьи ингибироватьактивности RGM, например, улюдей, которыестрадаютотнарушения, котороевключает, нонеограничиваетсяими, рассеянныйсклероз, травмуголовногомозгау млекопитающих, повреждениеспинногомозга, инсульт, нейродегенеративныезаболеванияи шизофрению.

公开(公告)号：DOP2010000258A

公开(公告)日：2010-09-15

申请号：DO2010000258

申请日：2010-08-24

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： MULLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNGMING ,  BARDWELL PHILLIP D

Abstract: Proteínas aisladas, particularmente anticuerpos monoclonales, que se unen y neutralizan la proteína RGM A. Específicamente, estos anticuerpos tienen la capacidad de inhibir la unión de RGM A a su receptor ylo sus correceptores. Los anticuerpos de la invención, o sus porciones, son útiles para detectar RGM A e inhibir la actividad de RGM A, por ejemplo, en un ser humano afectado por un trastorno que incluye, no taxativamente, esclerosis múltiple, traumatismo cerebral en mamíferos, lesiones en la médula espinal, accidente cerebrovascular, enfermedades neurodegenerativas, y esqu izofrenia.

公开(公告)号：CA2715456C

公开(公告)日：2020-10-27

申请号：CA2715456

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： MUELLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNG-MING ,  BARDWELL PHILLIP D

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/46

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

公开(公告)号：PH12013502068A1

公开(公告)日：2015-01-26

申请号：PH12013502068

申请日：2013-10-04

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： MULLER BERNHARD K ,  MARTIN SCHMIDT ,  BARLOW EVE H ,  LEDDY MARY R ,  CHUNG-MING HSIEH ,  BARDWELL PHILLIP D

IPC: A61K39/395 ,  C07K16/22

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

公开(公告)号：NZ587198A

公开(公告)日：2012-10-26

申请号：NZ58719809

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： MULLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNG-MING ,  BARDWELL PHILLIP D

IPC: C07K16/22 ,  A61K39/395

Abstract: Disclosed is an isolated antibody comprising an antigen binding domain, said antibody capable of binding an epitope of a RGM molecule, said antigen binding domain comprising a heavy chain variable domain having at least three complementary determining regions and a light chain variable domain having at least three complementary determining regions, wherein the at least three complementary determining regions of the heavy chain variable domain have the amino acid sequence of SEQ ID NO:57, SEQ ID NO:58 and SEQ ID NO:59 and the at least three complementary determining regions of the light chain variable domain have the amino acid sequence of SEQ ID NO: 60, SEQ ID NO:61 and SEQ ID NO:62. Further disclosed is an isolated antibody comprising an antigen binding domain, said antibody capable of binding an epitope of a RGM molecule, said antigen binding domain comprising a heavy chain variable domain and a light chain variable wherein the heavy chain variable domain has the amino acid sequence selected from the group consisting of: SEQ ID NOS: 35, 36, 37, 38, 39, 40, 41, 42, 43, 47, 48, 49 and 50 and wherein the light chain variable domain has the amino acid sequence selected from the group consisting of SEQ ID NO:44, 45, 46, 51, 52, 53 and 54.

公开(公告)号：CO6410314A2

公开(公告)日：2012-03-30

申请号：CO11108934

申请日：2011-08-25

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNING MARGARET ,  LEDDY MARY R ,  BRYANT SHAUGHN ,  WALLACE CRAIG ,  CLABBERS ANCA ,  TARCSA EDIT ,  ZHONG SUJU ,  PEREZ JENNIFER M ,  MEMMOTT JOHN E ,  KUTSKOVA YULIYA ,  MCRAE BRADFORD L ,  MURTAZA ANWAR

IPC: A61K39/395

Abstract: Se describen proteínas que se unen a IL-17 y/o IL-17F junto con su uso en la composición y métodos para el tratamiento, prevención y diagnóstico de enfermedades relacionadas con la IL-17 y para detectar IL-17 en células, tejidos, muestras y composiciones.

公开(公告)号：ECSP11011297A

公开(公告)日：2011-10-31

申请号：ECSP11011297

申请日：2011-09-01

Applicant: ABBOTT LAB

Inventor： LEDDY MARY R ,  HSIEH CHUNGMING ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H

IPC: A61K39/395

Abstract: Proteínas que unen IL-17 y/o IL-7F se describen junto con su uso en composición y métodos para el tratamiento, la prevención y el diagnóstico de enfermedades relacionadas con IL-17 y para la detección de IL-17 en células, tejidos, muestras y composiciones.

公开(公告)号：ECSP10010481A

公开(公告)日：2010-10-30

申请号：ECSP10010481

申请日：2010-09-13

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： MUELLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNGMING ,  BARDWELL PHILLIP D

IPC: A61K39/395 ,  C07K16/22

Abstract: Proteínas aisladas, particularmente anticuerpos monoclonales, que se unen y neutralizan la proteína RGM A. Específicamente, estos anticuerpos tienen la capacidad de inhibir la unión de RGM A a su receptor y/o sus correceptores. Los anticuerpos de la invención, o sus porciones, son útiles para detectar RGM A e inhibir la actividad de RGM A, por ejemplo, en un ser humano afectado por un trastorno que incluye, no taxativamente, esclerosis múltiple, traumatismo cerebral en mamíferos, lesiones en la médula espinal, accidente cerebrovascular, enfermedades neurodegenerativas, y esquizofrenia.

公开(公告)号：AU2009218693A1

公开(公告)日：2009-09-03

申请号：AU2009218693

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： SCHMIDT MARTIN ,  MULLER BERNHARD K ,  HSIEH CHUNG-MING ,  LEDDY MARY R ,  BARDWELL PHILLIP D ,  BARLOW EVE H

IPC: C07K16/22 ,  A61K39/395

Abstract: The subject invention relates to monoclonal antibodies which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or antigen binding fragments thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

公开(公告)号：SG173705A1

公开(公告)日：2011-09-29

申请号：SG2011058773

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.