公开(公告)号：WO2008082651A2

公开(公告)日：2008-07-10

申请号：PCT/US2007026482

申请日：2007-12-28

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

Inventor： HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

IPC: C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/245 ,  C07K2317/569 ,  C07K2317/92

Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-l a and human IL-I ß. The dual specific antibodies of the invention also neutralize both human IL-I a and human IC-I ß. The invention also provides domain antibodies (dAbs) specific for human IL-l a and human IL-l ß.

Abstract translation: 本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。 本发明的双重特异性抗体还中和人IL-1α和人IC-1β。 本发明还提供对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。

公开(公告)号：WO2011025964A3

公开(公告)日：2011-04-21

申请号：PCT/US2010047006

申请日：2010-08-27

Applicant: ABBOTT LAB ,  BENATUIL LORENZO ,  BOGHAERT ERWIN R ,  GU JIJIE ,  HARRIS MARIA ,  HICKSON JONATHAN A ,  HSIEH CHUNG-MING ,  KUTSKOVA YULIYA ,  LI YINGCHUN ,  LIU ZHIHONG ,  MORGAN-LAPPE SUSAN

Inventor： BENATUIL LORENZO ,  BOGHAERT ERWIN R ,  GU JIJIE ,  HARRIS MARIA ,  HICKSON JONATHAN A ,  HSIEH CHUNG-MING ,  KUTSKOVA YULIYA ,  LI YINGCHUN ,  LIU ZHIHONG ,  MORGAN-LAPPE SUSAN

IPC: C07K16/28

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.

Abstract translation: 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。

公开(公告)号：WO2010102251A3

公开(公告)日：2010-11-25

申请号：PCT/US2010026424

申请日：2010-03-05

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白以及其在用于治疗，预防和诊断IL-17相关疾病和检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的应用。

公开(公告)号：EP2114443A4

公开(公告)日：2011-08-10

申请号：EP07868125

申请日：2007-12-28

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

IPC: A61K39/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/245 ,  C07K2317/569 ,  C07K2317/92

公开(公告)号：EP2403531A4

公开(公告)日：2013-02-27

申请号：EP10749415

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

Abstract: Proteins capable of binding human IL-17 and TNF-± are described along with their use in composition and methods for treating, preventing, and diagnosing diseases related to IL- 17 and TNF-± related diseases and for detecting and/or TNF-± in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白质及其在治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。

公开(公告)号：CL2013003640A1

公开(公告)日：2014-07-25

申请号：CL2013003640

申请日：2013-12-18

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHH H ,  LEDDY MARY R ,  HUGUNIN MARGARET

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00

公开(公告)号：ECSP12011702A

公开(公告)日：2012-04-30

申请号：ECSP12011702

申请日：2012-02-29

Applicant: ABBOTT LAB

Inventor： BENATUIL LORENZO ,  BOGHAERT EDWIN R ,  GU JIJIE ,  HARRIS MARIA ,  HICKSON JONATHAN ,  HSIEH CHUNG MING ,  KUTSKOVA YULIYA ,  LI YINGCHUN ,  LIU ZHIHOMG ,  MORGAN LAPPE SUSAN

IPC: C07K16/28

Abstract: Se describen proteínas de unión a DLL4 mejoradas, se incluyen anticuerpos, anticuerpos con CDR injertadas, anticuerpos humanos, y fragmentos de unión a DLL4 de los mismos, proteínas que se unen a DLL4 con alta afinidad, y proteínas de unión a DLL4 que neutralizan la actividad de DLL4. Las proteínas de unión a DLL4 son útiles para tratar o prevenir cáncer y tumores, especialmente para el tratamiento o la prevención de la angiogénesis tumoral, y/u otras enfermedades dependientes de angiogénesis tales como la neovascularización ocular, o enfermedades independientes de la angiogénesis caracterizadas por expresión o actividad aberrante de DLL4 tal como trastornos autoinmune que incluyen la esclerosis múltiple.

公开(公告)号：AU2010286518A1

公开(公告)日：2012-03-29

申请号：AU2010286518

申请日：2010-08-27

Applicant: ABBOTT LAB

Inventor： BENATUIL LORENZO ,  BOGHAERT ERWIN R ,  GU JIJIE ,  HARRIS MARIA ,  HICKSON JONATHAN A ,  HSIEH CHUNG-MING ,  KUTSKOVA YULIYA ,  LI YINGCHUN ,  LIU ZHIHONG ,  MORGAN-LAPPE SUSAN

IPC: C07K16/28

Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.

公开(公告)号：CA2752648A1

公开(公告)日：2010-09-10

申请号：CA2752648

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

公开(公告)号：BRPI1013688A2

公开(公告)日：2016-10-11

申请号：BRPI1013688

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： CLABBERS ANCA ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  HSIEH CHUNG-MING ,  WALLACE CRAIG ,  TARCSA EDIT ,  PEREZ JENNIFER M ,  MEMMOTT JOHN E ,  HUGUNIN MARGARET ,  LEDDY MARY R ,  BRYANT SHAUGHN H ,  ZHONG SUJU ,  KUTSKOVA YULIYA

IPC: A61K39/395