公开(公告)号：WO2008082651A2

公开(公告)日：2008-07-10

申请号：PCT/US2007026482

申请日：2007-12-28

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

Inventor： HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

IPC: C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/245 ,  C07K2317/569 ,  C07K2317/92

Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-l a and human IL-I ß. The dual specific antibodies of the invention also neutralize both human IL-I a and human IC-I ß. The invention also provides domain antibodies (dAbs) specific for human IL-l a and human IL-l ß.

Abstract translation: 本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。 本发明的双重特异性抗体还中和人IL-1α和人IC-1β。 本发明还提供对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。

公开(公告)号：WO2010102251A3

公开(公告)日：2010-11-25

申请号：PCT/US2010026424

申请日：2010-03-05

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白以及其在用于治疗，预防和诊断IL-17相关疾病和检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的应用。

公开(公告)号：EP2114443A4

公开(公告)日：2011-08-10

申请号：EP07868125

申请日：2007-12-28

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

IPC: A61K39/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/245 ,  C07K2317/569 ,  C07K2317/92

公开(公告)号：EP2403531A4

公开(公告)日：2013-02-27

申请号：EP10749415

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

Abstract: Proteins capable of binding human IL-17 and TNF-± are described along with their use in composition and methods for treating, preventing, and diagnosing diseases related to IL- 17 and TNF-± related diseases and for detecting and/or TNF-± in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白质及其在治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。

公开(公告)号：BRPI1013688A2

公开(公告)日：2016-10-11

申请号：BRPI1013688

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： CLABBERS ANCA ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  HSIEH CHUNG-MING ,  WALLACE CRAIG ,  TARCSA EDIT ,  PEREZ JENNIFER M ,  MEMMOTT JOHN E ,  HUGUNIN MARGARET ,  LEDDY MARY R ,  BRYANT SHAUGHN H ,  ZHONG SUJU ,  KUTSKOVA YULIYA

IPC: A61K39/395

公开(公告)号：NZ594514A

公开(公告)日：2013-06-28

申请号：NZ59451410

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L

IPC: A61K39/395

Abstract: 594514 IL-17 BINDING PROTEINS Provided is binding protein comprising an antigen binding domain, wherein said binding protein binds human IL-17, said antigen binding domain comprises six CDRs with defined sequences. Corresponding DNA sequences for the variable domains are also provided. The antibodies can be used to treat a variety of diseases, including inflammation, autoimmunity and cancer.

公开(公告)号：SG173705A1

公开(公告)日：2011-09-29

申请号：SG2011058773

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

公开(公告)号：MX2011009362A

公开(公告)日：2011-09-26

申请号：MX2011009362

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  LEDDY MARY R ,  PEREZ JENNIFER M ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  TARCSA EDIT ,  MEMMOTT JOHN E ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  ZHONG SUJU ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H

IPC: A61K39/395

Abstract: Se describen proteínas que se unen a IL-17 y/o IL-17F junto con su uso en composiciones y métodos para tratar, prevenir, y diagnosticar enfermedades relacionadas con IL-17 y para detectar IL17 en células, tejidos, muestras, y composiciones.

公开(公告)号：CL2013003640A1

公开(公告)日：2014-07-25

申请号：CL2013003640

申请日：2013-12-18

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHH H ,  LEDDY MARY R ,  HUGUNIN MARGARET

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00

公开(公告)号：CA2752648A1

公开(公告)日：2010-09-10

申请号：CA2752648

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.