公开(公告)号：AU2007351514A1

公开(公告)日：2008-10-23

申请号：AU2007351514

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： KUMAR SHANKAR ,  CHEN YAN ,  BELK JONATHAN P ,  WU CHENGBIN ,  DIXON RICHARD W ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  YING HUA ,  MELIM TERRY L ,  HINTON PAUL R

IPC: C07K14/00 ,  C07H21/00 ,  C07K16/00 ,  C12N1/00 ,  C12N1/15 ,  C12N1/16 ,  C12N1/21 ,  C12N5/00 ,  C12N5/04 ,  C12N5/06 ,  C12P21/00

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：UA102503C2

公开(公告)日：2013-07-25

申请号：UAA200903345

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

IPC: C07K16/24 ,  A61K39/395 ,  A61P37/00 ,  C07K14/00 ,  C12N15/13 ,  C12P21/08

Abstract: Изобретениеотноситсяк белку (антителу), способномусвязыватьсяс IL-13, конъюгатуантитела, выделенноймолекуленуклеиновойкислоты, вектору, клетке-хозяина, способуполучениябелка. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, способулеченияу индивидазаболеванияилинарушения, вкоторомактивность IL-13 отрицательновлияетназдоровье, способууменьшенияактивности IL-13 уиндивидаи т.п.

公开(公告)号：NO20091411A

公开(公告)日：2009-05-22

申请号：NO20091411

申请日：2009-04-07

Applicant: ABBOTT LAB

Inventor： HINTON PAUL R ,  BELK JONATHAN P ,  DIXON RICHARD W ,  KUMAR SHANKAR ,  WU CHENGBIN ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  MELIM TERRY L ,  CHEN YAN

IPC: C07K16/28 ,  A61K39/395 ,  A61P37/00 ,  C07K16/46 ,  C12N5/06 ,  C12N5/10 ,  C12N15/13 ,  C12P21/08

CPC classification number: A61K45/06 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/47 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/481

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：CR10656A

公开(公告)日：2009-05-22

申请号：CR10656

申请日：2009-03-06

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

IPC: C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N1/21 ,  C12N5/00 ,  C12N5/04 ,  C12P21/00

Abstract: Proteinas de union a IL-13. Especificamente, la invencion se relaciona con anticuerpos que son quimericos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por la hIL-13 y neutralizan la actividad de la hIIL-13 in vitro e in vivo. Un anticuerpo de la invencion puede ser un anticuerpo de longitud completa o una porcion de union al antigeno del mismo.