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公开(公告)号：WO2008127271A3
公开(公告)日：2009-04-09
申请号：PCT/US2007019660
申请日：2007-09-07
Applicant: ABBOTT LAB , WU CHENGBIN , DIXON RICHARD W , BELK JONATHAN P , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , HINTON PAUL R , KUMAR SHANKAR , MELIM TERRY L , CHEN YAN
Inventor： WU CHENGBIN , DIXON RICHARD W , BELK JONATHAN P , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , HINTON PAUL R , KUMAR SHANKAR , MELIM TERRY L , CHEN YAN
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.
Abstract translation: 本发明包括IL-13结合蛋白。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hTL-13活性有害的病症的人类受试者中。
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2.发明申请
公开(公告)号：WO2012088290A2
公开(公告)日：2012-06-28
申请号：PCT/US2011066530
申请日：2011-12-21
Applicant: ABBOTT LAB , WU CHENGBIN , YING HUA , GHAYUR TARIQ , GOODREAU CARRIE , BARDWELL PHILIP
Inventor： WU CHENGBIN , YING HUA , GHAYUR TARIQ , GOODREAU CARRIE , BARDWELL PHILIP
IPC: A61K39/395 , A61P37/04 , C07K16/24 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/00 , G01N33/53
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/241 , C07K16/244 , C07K16/26 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/31 , C07K2317/35 , C07K2317/56 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N2333/525 , G01N2333/54 , G01N2405/00
Abstract: The present invention provides engineered multivalent and multispecific binding proteins, as well as methods of making them. Methods for using the multivalent and multispecific binding proteins of the invention in the prevention, diagnosis, and/or treatment of disease are also provided.
Abstract translation: 本发明提供工程化的多价和多特异性结合蛋白，以及制备它们的方法。 还提供了在预防，诊断和/或治疗疾病中使用本发明的多价和多特异性结合蛋白的方法。
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公开(公告)号：WO2011050262A3
公开(公告)日：2011-06-30
申请号：PCT/US2010053730
申请日：2010-10-22
Applicant: ABBOTT LAB , GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
IPC: C12P21/08
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2009134776A3
公开(公告)日：2009-12-23
申请号：PCT/US2009041945
申请日：2009-04-28
Applicant: ABBOTT LAB , GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
IPC: A61K39/00
CPC classification number: C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y10S435/81
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在疾病的预防，诊断和/或治疗中的用途。
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公开(公告)号：EP2282769A4
公开(公告)日：2012-04-25
申请号：EP09739578
申请日：2009-04-28
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
CPC classification number: C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y10S435/81
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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Patent Agency Ranking
公开(公告)号：EP2491129A4
公开(公告)日：2013-05-29
申请号：EP10825739
申请日：2010-10-22
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：EP2064336A4
公开(公告)日：2010-03-17
申请号：EP07873427
申请日：2007-09-07
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , DIXON RICHARD W , BELK JONATHAN P , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , HINTON PAUL R , KUMAR SHANKAR , MELIM TERRY L , CHEN YAN
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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公开(公告)号：SG190572A1
公开(公告)日：2013-06-28
申请号：SG2013030655
申请日：2009-04-28
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：NZ588554A
公开(公告)日：2013-03-28
申请号：NZ58855409
申请日：2009-04-28
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
IPC: A61K39/00
Abstract: Disclosed is a binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; n is 0 or 1. Furthermore, the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site and are as defined in the specification. The disclosed binding protein is capable of binding to VEGF with an EC50 of at most about 28.25 nM, as measured by direct bind ELISA, and/or the binding protein is capable of binding to DLL4 with an EC50 of at most about 2.12nM, as measured by direct bind ELISA.
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公开(公告)号：CO6331296A2
公开(公告)日：2011-10-20
申请号：CO10134183
申请日：2010-10-28
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN , YING HUA , BELL RANDY , WANG JIEYI , PHILLIPS ANDREW , KINGSBURY GILIAN , REILLY EDWARD
IPC: A61K39/00
Abstract: La presente invención se relaciona con proteínas de unión multivalentes y multiespecíficas diseñadas, con los métodos de preparación y específicamente con sus usos en la prevención, diagnóstico y/o tratamiento de enfermedad.
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