中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

750 records (took 0.047 seconds)

    HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
    11.
    发明申请
    HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 审中-公开
    作为紫杉醇生物合成酶的抑制剂的二异丙氧基甲基邻氨基甲酸酯

    公开(公告)号：WO1998014429A1

    公开(公告)日：1998-04-09

    申请号：PCT/US1997017265

    申请日：1997-09-26

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  KOLASA, Teodozyj ,  BROOKS, C., D., W. ,  GUNN, David, E.

    IPC: C07D215/14

    CPC classification number: C07D405/14 ,  C07D215/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14

    Abstract: Compounds having formula (I), wherein W and W are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted naphthyl; R anb R are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R is selected from thienyl, furyl, phenyl, naphthyl, benzo[b]thienyl, alkyl, hydroxyl, and hydrogen; Y an alkylene of one to six carbon atoms; and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR , (c) -NR R , (d) -NR SO2R (e) -NH-Tetrazolyl, and (f) glycinyl; inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

    Abstract translation: 具有式（I）的化合物，其中W 1和W 2独立地选自任选取代的喹啉基，任选取代的苯并噻唑基，任选取代的苯并恶唑基，任选取代的苯并咪唑基，任选取代的喹喔啉基，任选取代的萘基; R 1和R 2独立地选自氢，烷基，卤代烷基，烷氧基，卤素; R 3选自噻吩基，呋喃基，苯基，萘基，苯并[b]噻吩基，烷基，羟基和氢; Y为1至6个碳原子的亚烷基; 并且M选自（a）药学上可接受的代谢可裂解基团，（b）-OR 4，（c）-NR 5 R 6，（d）-NR 4 SO 2 R 7 e）-NH-四唑基，和（f）甘氨酰; 抑制白细胞三烯生物合成，可用于治疗过敏性和炎性疾病状态。 还公开了白三烯生物合成抑制组合物和抑制白三烯生物合成的方法。

    SYRINGE SYSTEM ACCOMMODATING SEPARATE PREFILLED BARRELS FOR TWO CONSTITUENTS
    12.
    发明申请
    SYRINGE SYSTEM ACCOMMODATING SEPARATE PREFILLED BARRELS FOR TWO CONSTITUENTS 审中-公开
    适用于两种组织的单独预制棒的SYRINGE系统

    公开(公告)号：WO1998013088A1

    公开(公告)日：1998-04-02

    申请号：PCT/US1997017194

    申请日：1997-09-25

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  GRABENKORT, Richard, W. ,  HOFSTETTER, John, M. ,  O'NEIL, John, A.

    IPC: A61M05/315

    CPC classification number: A61M5/31596 ,  A61M2005/31598

    Abstract: A prefilled, two-constituent system is provided with first and second containers or barrels. The first barrel includes a first chamber having a dispensing end or delivery end. The delivery end defines a dispensing passage or delivery passage communicating through the delivery end to accommodate the dispensing of fluid from the first chamber. A movable seal or reciprocable stopper is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the delivery end and the stopper. A second container or barrel is sized to be disposed in the first barrel and has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the second barrel. A plunger is slidably disposed within the second barrel. A liquid second constituent is provided in the second barrel between the discharge end and the plunger. The first barrel stopper and the second barrel discharge end are engageable directly or indirectly to cooperatively define a coupling accommodating the flow of the liquid second constituent from the second barrel into the first chamber of the first barrel as the second barrel moves outwardly relative to the first chamber.

    Abstract translation: 预填充的双组分系统设置有第一和第二容器或桶。 第一桶包括具有分配端或输送端的第一室。 输送端限定分配通道或输送通道，其通过输送端连通以适应来自第一室的流体的分配。 可移动的密封件或可往复运动的塞子可滑动地设置在第一腔室中，并且第一构件在第一腔室中设置在输送端和塞子之间。 第二容器或筒的尺寸设置成设置在第一筒中，并且具有限定通过排出端连通的排放通道的排放端，以适应来自第二筒的流体的排放。 柱塞可滑动地设置在第二筒内。 在排出端和柱塞之间的第二筒体中设置液体第二成分。 第一筒塞和第二筒排放端可直接或间接地接合，以协作地限定一个联接器，当第二筒相对于第一筒排出端向外移动时，该联接器将液体第二成分从第二筒体的流动容纳到第一桶的第一室中 室。

    6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY
    14.
    发明申请
    6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY 审中-公开
    具有抗生素活性的6-O-取代的硬脂酸酯

    公开(公告)号：WO1998009978A1

    公开(公告)日：1998-03-12

    申请号：PCT/US1997015506

    申请日：1997-09-02

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  MA, Zhenkun ,  CLARK, Richard, F. ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J.

    IPC: C07H17/08

    CPC classification number: C07H17/08 ,  Y02P20/55

    Abstract: Antimicrobial compounds having formula (II), (III), (IV), (IV-A) or (V) as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compunds.

    Abstract translation: 具有式（II），（III），（IV），（IV-A）或（V）的抗微生物化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 以及制备肥料的过程。

    METHOD AND APPARATUS FOR PERFORMING AUTOMATED ANALYSIS
    15.
    发明申请
    METHOD AND APPARATUS FOR PERFORMING AUTOMATED ANALYSIS 审中-公开
    用于执行自动分析的方法和装置

    公开(公告)号：WO1998002727A1

    公开(公告)日：1998-01-22

    申请号：PCT/US1997011105

    申请日：1997-06-26

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  GILL, James, E. ,  CHUPP, Vernon, L. ,  VAN HOVE, Luc

    IPC: G01N15/14

    CPC classification number: G01N35/1095 ,  B01F5/0453 ,  B01F5/046 ,  G01N1/14 ,  G01N15/14 ,  G01N15/1404 ,  G01N15/1459 ,  G01N35/0092 ,  G01N35/10 ,  G01N35/1004 ,  G01N35/109 ,  G01N2015/0069 ,  G01N2015/0076 ,  G01N2015/0084 ,  G01N2015/1413 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/1032 ,  Y10S435/973 ,  Y10S436/805 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

    Abstract: Provided are automated methods for distinguishing and differentiating cells in a whole blood sample. In one of the methods, a whole blood sample is provided. One or more tests to be performed on the whole blood sample is selected. The tests to be performed on the whole blood sample are correlated. A volume of the whole blood sample is aspirated into an automated instrument system which automatically performs conventional hematology analysis and fluorescent cytometry analysis on the whole blood sample. A first aliquot of the whole blood sample is dispensed into at least one sample receiving vessel. The first aliquot of the whole blood sample is mixed with a fluorescent reagent. The first aliquot of the whole blood sample mixed with fluorescent reagent is diluted and transported through a flow transducer system. The flow transducer system detects multi-angle light scatter and fluorescence from the first aliquot of the whole blood sample mixed with fluorescent reagent and counts and differentiates platelets or platelet clumps or both in the sample. Detecting and differentiation data for the one or more tests performed on the whole blood sample are stored. Results of the one or more tests performed on the whole blood sample are reported in a quantitative manner if so requested. The instrument system automatically performs all method steps without physically separating cells from the whole blood sample or an aliquot of the sample and results of a conventional hematology analysis may be utilized in at least reporting of results of the fluorescent cytometry testing.

    Abstract translation: 提供了用于区分和分化全血样品中的细胞的自动化方法。 在其中一种方法中，提供全血样品。 选择对全血样进行一次或多次测试。 对全血样进行测试是相关的。 将全血样品的体积吸入自动化仪器系统中，自动进行全血样品的常规血液学分析和荧光细胞分析。 将全血样品的第一等分试样分配到至少一个样品接收容器中。 将全血样品的第一等份与荧光试剂混合。 与荧光试剂混合的全血样品的第一等份被稀释并通过流量传感器系统传输。 流量传感器系统检测来自与荧光试剂混合的全血样品的第一等分试样的多角度光散射和荧光，并对样品中的血小板或血小板结块或两者进行计数和微分。 存储对全血样品进行的一次或多次测试的检测和分化数据。 如果要求，则以定量方式报告对全血样品进行的一项或多项测试的结果。 仪器系统自动执行所有方法步骤，而不用从全血样品或样品的等分试样物质分离细胞，并且常规血液学分析的结果可以用于至少报告荧光细胞测定结果。

    BROMOTIACUMICIN COMPOUNDS
    16.
    发明申请
    BROMOTIACUMICIN COMPOUNDS 审中-公开
    BROMOTIACUMICIN化合物

    公开(公告)号：WO1998002447A1

    公开(公告)日：1998-01-22

    申请号：PCT/US1997011064

    申请日：1997-06-24

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  HOCHLOWSKI, Jill, E. ,  JACKSON, Marianna ,  McALPINE, James, B. ,  RASMUSSEN, Ronald, R.

    IPC: C07H17/08

    CPC classification number: C07H17/08

    Abstract: Antimicrobial compounds having formula (I) wherein R and R are independently selected from the group consisting of hydrogen and C1-to-C4 alkanoyl; R and R are selected from the group consisting of (a) R is hydrogen and R is hydroxy, (b) R is hydroxy and R is hydrogen, (c) R and R taken together are =0; or selected from the group consisting of hydrogen and hydroxy; and R and R are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R and R must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.

    Abstract translation: 式（I）的抗微生物化合物，其中R 1和R 2独立地选自氢和C 1 -C 4烷酰基; R 3和R 4选自（a）R 3是氢和R 4是羟基，（b）R 3是羟基，R 4是氢， （c）R 3和R 4一起为= 0; 或选自氢和羟基; R 5和R 6独立地选自氢，溴和氯，条件是R 5和R 6中的至少一个必须是溴。 还公开了包含这些化合物的药物组合物，通过其施用治疗细菌感染的方法和制备所述化合物的方法。

    MACROCYCLIC 13-MEMBERED RING DERIVATIVES OF ERYTHROMYCINS A AND B
    17.
    发明申请
    MACROCYCLIC 13-MEMBERED RING DERIVATIVES OF ERYTHROMYCINS A AND B 审中-公开
    红霉素A和B的大环13-环状衍生物

    公开(公告)号：WO1997048713A1

    公开(公告)日：1997-12-24

    申请号：PCT/US1997007015

    申请日：1997-04-25

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  LARTEY, Paul, A. ,  CURTY, Cynthia, Brunell ,  FAGHIH, Ramin ,  NELLANS, Hugh, Nerby ,  PETERSEN, Albert, Christian

    IPC: C07H17/08

    CPC classification number: C07H17/08

    Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having formula (I) and pharmaceutically acceptable salts thereof, wherein R, R , R , R and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

    Abstract translation: 衍生自具有式（I）的红霉素A和B的新型大环13-环收缩的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 3和X是具体定义的，其具有 用于治疗与高肌钙蛋白血症相关的胃肠道疾病，其药物组合物，用所述药物组合物治疗与高肌醇酐血症相关的胃肠道疾病的方法及其制备方法。

    6-O-SUBSTITUTED ERYTHROMYCINS AND METHOD FOR MAKING THEM
    18.
    发明申请
    6-O-SUBSTITUTED ERYTHROMYCINS AND METHOD FOR MAKING THEM 审中-公开
    6-O-取代的红霉素及其制备方法

    公开(公告)号：WO1997042204A1

    公开(公告)日：1997-11-13

    申请号：PCT/US1997004622

    申请日：1997-03-21

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  CLARK, Richard, F. ,  MA, Zhenkun

    IPC: C07H17/08

    CPC classification number: C07H17/08

    Abstract: Antimicrobial compounds having formula (II), (III), (IV), (V), (VI), (VII), (VIII) and (IX) as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

    Abstract translation: 具有式（II），（III），（IV），（V），（VI），（VII），（VIII）和（IX）的抗微生物化合物及其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

Patent Agency Ranking