公开(公告)号：WO1997034924A1

公开(公告)日：1997-09-25

申请号：PCT/US1997001954

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K07/23

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及以相同方法有用的中间体肽的方法。

公开(公告)号：WO2010111348A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028433

申请日：2010-03-24

Applicant: ABBOTT LABORATORIES ,  NAPIER, James, J. ,  CALIFANO, Jean-Christophe

Inventor： NAPIER, James, J. ,  CALIFANO, Jean-Christophe

IPC: C07D239/54 ,  C07D311/08

CPC classification number: C07D239/54 ,  C07C303/40 ,  C07C311/08 ,  C07F7/0812

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia , are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

Abstract translation: 本发明涉及：（a）制备其特别是可用于抑制丙型肝炎病毒（HCV）的化合物及其盐的方法; （b）可用于制备化合物和盐的中间体; （c）包含该化合物或其盐的药物组合物; 和（d）使用这种组合物的方法。

公开(公告)号：WO1997034923A1

公开(公告)日：1997-09-25

申请号：PCT/US1997001912

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K07/23

CPC classification number: C07K5/06165 ,  A61K38/00 ,  C07D307/14 ,  C07K5/06086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/23

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及用于相同方法的中间肽的方法。

公开(公告)号：EP2411372A1

公开(公告)日：2012-02-01

申请号：EP10711968.7

申请日：2010-03-24

Applicant: Abbott Laboratories

Inventor： NAPIER, James, J. ,  CALIFANO, Jean-Christophe ,  BECKER, Calvin, L. ,  YU, Su

IPC: C07D239/54 ,  C07D311/08

CPC classification number: C07D239/54 ,  C07C303/40 ,  C07C311/08 ,  C07F7/0812

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that,
inter alia , are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

公开(公告)号：EP0889901A1

公开(公告)日：1999-01-13

申请号：EP97904253.0

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07D307 ,  A61K31 ,  A61K38 ,  A61P5 ,  C07K1 ,  C07K5 ,  C07K7

CPC classification number: C07K5/06165 ,  A61K38/00 ,  C07D307/14 ,  C07K5/06086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/23

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

公开(公告)号：EP0889901B1

公开(公告)日：2001-09-19

申请号：EP97904253.8

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K7/23 ,  C07K1/06 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07D307/14

CPC classification number: C07K5/06165 ,  A61K38/00 ,  C07D307/14 ,  C07K5/06086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/23

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

公开(公告)号：EP0914334B1

公开(公告)日：2001-05-30

申请号：EP97905825.2

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K7/23 ,  C07K1/06 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07D307/14

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

公开(公告)号：EP0914334A1

公开(公告)日：1999-05-12

申请号：EP97905825.0

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07D307 ,  A61K31 ,  A61K38 ,  A61P5 ,  A61P13 ,  A61P35 ,  C07K1 ,  C07K5 ,  C07K7

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.