公开(公告)号：WO1997034924A1

公开(公告)日：1997-09-25

申请号：PCT/US1997001954

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K07/23

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及以相同方法有用的中间体肽的方法。

公开(公告)号：WO2011146179A2

公开(公告)日：2011-11-24

申请号：PCT/US2011/032279

申请日：2011-04-13

Applicant: ABBOTT LABORATORIES ,  WANG, Chen ,  HICKMAN, Robert, K. ,  LUNDELL, Edwin, O. ,  HEGEDUS, Roy, D.

Inventor： WANG, Chen ,  HICKMAN, Robert, K. ,  LUNDELL, Edwin, O. ,  HEGEDUS, Roy, D.

IPC: C07K1/36 ,  C07K1/18 ,  C07K1/22 ,  C07K1/34 ,  B01D15/12 ,  B01D15/38

CPC classification number: C07K1/36 ,  B01D15/305 ,  B01D15/327 ,  B01D15/361 ,  B01D15/3804 ,  B01D15/3847 ,  C07K1/165 ,  C07K1/18 ,  C07K1/22 ,  C07K1/34

Abstract: The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, a depth filter, and a mixed-mode chromatography resin. A membrane adsorber or monolith may be substituted for the mixed-mode chromatography column.

Abstract translation: 本发明涉及一种纯化蛋白质的装置和方法。 该装置包括使用捕获色谱树脂，在捕获色谱树脂之后布置的深度过滤器，以及布置在深度过滤器之后的混合型色谱树脂。 该方法包括提供含有蛋白质的样品，通过捕获色谱树脂，深度过滤器和混合模式色谱树脂处理样品。 膜吸附器或整体可以代替混合模式色谱柱。

公开(公告)号：WO1997034923A1

公开(公告)日：1997-09-25

申请号：PCT/US1997001912

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K07/23

CPC classification number: C07K5/06165 ,  A61K38/00 ,  C07D307/14 ,  C07K5/06086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/23

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及用于相同方法的中间肽的方法。

公开(公告)号：EP0889901A1

公开(公告)日：1999-01-13

申请号：EP97904253.0

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07D307 ,  A61K31 ,  A61K38 ,  A61P5 ,  C07K1 ,  C07K5 ,  C07K7

CPC classification number: C07K5/06165 ,  A61K38/00 ,  C07D307/14 ,  C07K5/06086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/23

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

公开(公告)号：EP0889901B1

公开(公告)日：2001-09-19

申请号：EP97904253.8

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K7/23 ,  C07K1/06 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07D307/14

CPC classification number: C07K5/06165 ,  A61K38/00 ,  C07D307/14 ,  C07K5/06086 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/23

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

公开(公告)号：EP0914334B1

公开(公告)日：2001-05-30

申请号：EP97905825.2

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K7/23 ,  C07K1/06 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07D307/14

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

公开(公告)号：EP0914334A1

公开(公告)日：1999-05-12

申请号：EP97905825.0

申请日：1997-02-06

Applicant: Abbott Laboratories

Inventor： FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07D307 ,  A61K31 ,  A61K38 ,  A61P5 ,  A61P13 ,  A61P35 ,  C07K1 ,  C07K5 ,  C07K7

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.