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    ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES
    11.
    发明申请
    ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES 审中-公开
    CARDIAC TROPONIN AUTOANTIBODIES的测定

    公开(公告)号：WO2008051761A2

    公开(公告)日：2008-05-02

    申请号：PCT/US2007/081606

    申请日：2007-10-17

    Applicant: ABBOTT LABORATORIES ,  MATTINGLY, Phillip G ,  ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  DOSS, Robert C

    Inventor： MATTINGLY, Phillip G ,  ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  DOSS, Robert C

    IPC: G01N33/53

    CPC classification number: G01N33/6854 ,  G01N33/54326 ,  G01N33/564 ,  G01N2800/324 ,  G01N2800/325 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/25125

    Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

    Abstract translation: 本发明尤其提供基于测定心肌肌钙蛋白自身抗体的方法和试剂盒，或者结合心肌肌钙蛋白的测定和/或作为心脏病理学的独立指示物，例如心肌炎，心肌病 和/或缺血性心脏病。 本发明的测定方法尤其可用于鉴定患有自身免疫性疾病或与患有自身免疫性疾病的个体相关的个体的心脏病理学或其风险。 在具体的实施方案中，本发明还提供了确定患有心脏病理学或处于心脏病理学危险中的受试者是否是免疫抑制疗法或免疫吸收疗法的候选者的方法。 本发明还提供对于实施本发明的方法有用的试剂盒和试剂盒组分。

    REAGENTS FOR MEASURING LEAD LEVELS VIA THE QUANTIFICATION OF PORPHOBILINOGEN
    12.
    发明申请
    REAGENTS FOR MEASURING LEAD LEVELS VIA THE QUANTIFICATION OF PORPHOBILINOGEN 审中-公开
    用于通过定量的方法测量铅水平的试剂

    公开(公告)号：WO1997024621A2

    公开(公告)日：1997-07-10

    申请号：PCT/US1996019544

    申请日：1996-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  FISHPAUGH, Jeffrey, R. ,  HEUSER, Kevin ,  RAMP, John, M. ,  WONG, Martin

    IPC: G01N33/72

    CPC classification number: C07D207/337 ,  C07D405/12 ,  G01N33/532 ,  G01N33/72 ,  G01N33/84

    Abstract: Immunoassay methods and reagents for measuring the levels of lead in a test sample via the quantification of porphobilinogen use antibodies prepared with compounds of Formulas (II) and (III), wherein X and Y are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to an immunogenic carrier material P wherein P is preferably bovine serum albumin. Also described are the synthesis of fluorescein tracers of the structure of Formulas (V) and (VII), wherein A and C are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to a detectable moiety Q, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.

    Abstract translation: 用于通过定量用式（II）和（III）化合物制备的胆色素原使用抗体来测定测试样品中铅含量的免疫测定方法和试剂，其中X和Y是由0至2个杂原子组成的连接基团和0至 8个碳原子与免疫原性载体材料P连接，其中P优选为牛血清白蛋白。 还描述了式（V）和（VII）结构的荧光素示踪剂的合成，其中A和C是连接到可检测部分Q的0至2个杂原子和0至8个碳原子组成的连接基团，其中Q 是可检测的部分，优选荧光素或荧光素衍生物。

    N-PROTECTED AMINOALKYLALDEHYDES
    13.
    发明申请
    N-PROTECTED AMINOALKYLALDEHYDES 审中-公开
    N-保护的氨基甲醛

    公开(公告)号：WO1992012122A1

    公开(公告)日：1992-07-23

    申请号：PCT/US1991009791

    申请日：1991-12-27

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  CHEN, Yon-Yi

    IPC: C07C261/00

    CPC classification number: G01N33/54353 ,  C07C271/18

    Abstract: A method for synthesizing novel N-protected aminoalkylaldehydes having aldehyde and amino termini and which are useful as crosslinking reagents for preparing conjugates with biologically active compounds is described. N-benzyloxy-carbonylaminoalkylalcohols and N-butyloxy-carbonylaminoalkylalcohols are oxidized with a Dess-Martin periodinane reagent to provide N-protected aminoaldehydes for use as heterobifunctional crosslinking reagents.

    Abstract translation: 描述了用于合成具有醛和氨基末端的新型N-保护的氨基烷基醛的方法，其可用作制备与生物活性化合物的缀合物的交联剂。 N-苄氧基 - 羰基氨基烷基醇和N-丁氧基羰基氨基烷基醇用Dess-Martin高碘烷试剂氧化，得到N-保护的氨基醛，用作异双功能交联试剂。

    DETERMINATION OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE PRESENCE OF INTERFERING SUBSTANCES
    19.
    发明申请
    DETERMINATION OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE PRESENCE OF INTERFERING SUBSTANCES 审中-公开
    干扰物质存在下三氯化锑抗体药物的测定

    公开(公告)号：WO1993012424A1

    公开(公告)日：1993-06-24

    申请号：PCT/US1991009389

    申请日：1991-12-13

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  FISHPAUGH, Jeffrey, R. ,  HARRINGTON, Charles, A. ,  HARTTER, Daryl, E.

    IPC: G01N33/53

    CPC classification number: G01N33/9466

    Abstract: Method and reagents for determining a compound of interest present in a test sample also containing one or more interfering compounds having substantially similar chemical structures, and otherwise analytically indistinguishable from each other, employing a pretreatment reagent capable of selectively modifying the chemical structure of one of the compounds without significantly modifying or altering the chemical structure of the other one of the compounds. The selective modification results in the modified compound having a chemical structure which is substantially dissimilar to the chemical structure of the other one of said compounds wherein the compounds are substantially distinguishable from each other to permit the analytical determination of one or the other of such compounds by immunoassay, high pressure liquid chromatography, and thin layer chromatography techniques, especially for the fluorescent polarization immunoassay determination of tricyclic antidepressant drugs in the presence of phenothiazines.

    Abstract translation: 用于确定测试样品中存在的化合物的方法和试剂，其还含有一种或多种具有基本上相似化学结构的干扰化合物，或者以其它方式在分析上彼此不可区分，使用能够选择性地改变其中一种化学结构的化学结构的预处理试剂 化合物，而不显着改变或改变另一种化合物的化学结构。 所述选择性修饰导致具有化学结构的改性化合物，其化学结构基本上不同于所述化合物中的另一种化合物的化学结构，其中所述化合物彼此基本上可区分，以允许通过以下方式分析其中一种或另一种化合物： 免疫测定，高压液相色谱和薄层色谱技术，特别是在吩噻嗪存在下进行三环抗抑郁药物的荧光偏振免疫测定。

    REAGENTS AND METHODS FOR THE QUANTIFICATION OF TOTAL DOXEPINS IN BIOLOGICAL FLUIDS
    20.
    发明申请
    REAGENTS AND METHODS FOR THE QUANTIFICATION OF TOTAL DOXEPINS IN BIOLOGICAL FLUIDS 审中-公开
    在生物流体中定量总DOXEPINS的试剂和方法

    公开(公告)号：WO1993003372A1

    公开(公告)日：1993-02-18

    申请号：PCT/US1992006318

    申请日：1992-07-29

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  FISHPAUGH, Jeffrey, R. ,  HRUSKA, Robert, E. ,  JOHNSON, Donald

    IPC: G01N33/533

    CPC classification number: C07D313/12 ,  G01N33/533 ,  G01N33/9466 ,  Y10S436/815

    Abstract: Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immunoassay employing antibodies and labeled reagents prepared with doxepin derivatives of formula (II), wherein Y-Z can be C=CH or N-CH2, R1 is a linking group, R2 can be H or CH3 and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of formula (II), and the labeled reagent is also prepared from the doxepin derivative of formula (II).

    Abstract translation: 公开了用于定量测试样品中总多塞平（即，多西霉素，Z-多塞平，E-脱甲基脱氧蛋白和Z-去甲基去氧吗啡）的免疫测定方法和试剂。 总多塞平的定量是在使用抗体和由式（II）的多塞平衍生物制备的标记试剂的免疫测定中完成的，其中YZ可以是C = CH或N-CH 2，R 1是连接基团，R 2可以是H或CH 3， Q可以是可检测部分或免疫原性载体材料。 抗体试剂包括能够结合总多塞平并且由一种或多种由式（II）的多塞平衍生物制备的免疫原产生的抗体，并且标记的试剂也由式（II）的多塞平衍生物制备。

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