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11.发明申请BIS (HETERO ) ARYL SUBSTITUTED ISOXAZOLES FOR USE AS NEURONAL NICOTINIC RECEPTOR MODULATORS 审中-公开BIS（HETERO）ARYL替代的ISOXAZOLES用作神经激素受体调节剂
公开(公告)号：WO2009149135A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046042
申请日：2009-06-03
Applicant: ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , JI, Jianguo , LEE, Chih-Hung , LI, Tao , SIPPY, Kevin, B.
Inventor： GOPALAKRISHNAN, Murali , JI, Jianguo , LEE, Chih-Hung , LI, Tao , SIPPY, Kevin, B.
IPC: C07D413/04 , C07D413/14 , A61K31/42 , A61P25/28
CPC classification number: C07D413/14 , C07D413/04
Abstract: The invention relates to isoxazole derivatives of formila (I), compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及甲醛（I）的异恶唑衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物预防或治疗病症和障碍的方法。
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12.发明申请AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF 审中-公开作为阳性调节剂的酰胺衍生物及其使用方法
公开(公告)号：WO2009145996A2
公开(公告)日：2009-12-03
申请号：PCT/US2009/038474
申请日：2009-03-27
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael, R. , MORTELL, Kathleen, H. , NERSESIAN, Diana, L. , LEE, Chih-Hung , CLAPHAM, Bruce
Inventor： SCHRIMPF, Michael, R. , MORTELL, Kathleen, H. , NERSESIAN, Diana, L. , LEE, Chih-Hung , CLAPHAM, Bruce
IPC: C07C323/42 , A61K31/166 , A61K31/265 , A61P25/28
CPC classification number: C07C323/62 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/325 , C07D207/327 , C07D207/38 , C07D209/14 , C07D215/12 , C07D233/61 , C07D243/08 , C07D295/112 , C07D295/135 , C07D307/52 , C07D309/14 , C07D333/20
Abstract: The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
Abstract translation: 本发明涉及作为神经元烟碱性受体的正变构调节剂的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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公开(公告)号：WO2008079683A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/087163
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES , GOMTSYAN, Arthur R. , SCHMIDT, Robert G. , DAANEN, Jerome F. , BAYBURT, Erol K. , LEE, Chih-Hung , LATSHAW, Steven P.
Inventor： GOMTSYAN, Arthur R. , SCHMIDT, Robert G. , DAANEN, Jerome F. , BAYBURT, Erol K. , LEE, Chih-Hung , LATSHAW, Steven P.
IPC: C07C275/32 , C07D311/58 , C07D215/42 , A61K31/17 , A61K31/353 , A61K31/47 , A61P25/04
CPC classification number: C07C275/32 , C07D215/12 , C07D215/42 , C07D215/54 , C07D311/58 , C07D311/74
Abstract: The present application is directed to compounds that are TRPV1 antagonictc and have formula(I): wherein variables Ar 1 , L 1 , R 1 , R 2 , R 3 , R 4 , R 5 , Y 1 , Y 2 , and Y 3 , are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
Abstract translation: 本申请涉及TRPV1拮抗剂并具有式（I）的化合物：其中变量Ar 1，L 1，R 1， R 2，R 3，R 4，R 5，Y 1， Y 2和Y 3是如描述中所定义的，其可用于治疗由香草素受体活性引起或加剧的病症。
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14.发明申请BENZISOTHIAZOLE-1, 1-DIOXIDE ACTING AS ANTAGONISTS TO THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF 审中-公开苯并噻唑-1,1-二氧化物作为VANILLOID受体亚型1（VR1）的拮抗剂及其用途
公开(公告)号：WO2006065646A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/044613
申请日：2005-12-07
Applicant: ABBOTT LABORATORIES , BROWN, Brian, S. , KEDDY, Ryan, G. , LEE, Chih-Hung
Inventor： BROWN, Brian, S. , KEDDY, Ryan, G. , LEE, Chih-Hung
IPC: C07D417/04 , A61K31/425
CPC classification number: C07D451/02 , C07D275/06 , C07D417/04
Abstract: Compounds having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein L, A, G, R 1 , R 2 and R 3 are as defined herein. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.
Abstract translation: 具有式（I）化合物或其药学上可接受的盐，前药或其前体药物的盐，其中L，A，G，R 1，R 2和R 2， SUP> 3 如本文所定义。 这些化合物特别可用于治疗疼痛，炎性痛觉过敏和尿功能障碍，例如膀胱过度活动和尿失禁。
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15.发明申请(2S)-AMINO(PHENYL)ACETIC ACID AND DERIVATIVES AS α2δ VOLTAGE-GATED CALCIUM CHANNEL LIGANDS 审中-公开（2S）-AMINO（苯乙烯）乙酸和衍生物作为α2delta电压通道钙通道配体
公开(公告)号：WO2005067911A1
公开(公告)日：2005-07-28
申请号：PCT/US2004/040965
申请日：2004-12-08
Applicant: ABBOTT LABORATORIES , LEE, Chih-Hung , JARVIS, Michael, F.
Inventor： LEE, Chih-Hung , JARVIS, Michael, F.
IPC: A61K31/198
CPC classification number: A61K31/198 , A61K31/485
Abstract: The present invention relates to a method of treating disorders associated with the α 2 δ voltage-gated calcium channel ligand, comprising the administration of compounds of formula (I), or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof.
Abstract translation: 本发明涉及一种治疗与α2δ电压门控钙通道配体相关的疾病的方法，包括施用式（I）化合物或其药学上可接受的盐，酰胺，酯或前药。
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Patent Agency Ranking
公开(公告)号：WO2010036998A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/058553
申请日：2009-09-28
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
Inventor： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
IPC: A61K31/439 , C12Q1/02 , C07D471/08
CPC classification number: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：WO2009148452A1
公开(公告)日：2009-12-10
申请号：PCT/US2008/066002
申请日：2008-06-06
Applicant: ABBOTT LABORATORIES , JI, Jianguo , LEE, Chih-Hung , SIPPY, Kevin, B. , LI, Tao , GOPALAKRISHNAN, Murali
Inventor： JI, Jianguo , LEE, Chih-Hung , SIPPY, Kevin, B. , LI, Tao , GOPALAKRISHNAN, Murali
IPC: C07D413/04 , C07D271/06
CPC classification number: C07D271/06 , A61K31/495 , A61K45/06 , C07D413/04 , C07D413/14 , C07D471/04 , A61K2300/00
Abstract: The invention relates to 1,2,4 oxadiazole compounds and analogs thereof, represented by formula (II), and compositions and methods of use thereof.
Abstract translation: 本发明涉及由式（II）表示的1,2,4-恶二唑化合物及其类似物，及其组合物和使用方法。
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18.发明申请ANTAGONISTS TO THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF 审中-公开对VANILLOID受体亚型1（VR1）的拮抗作用及其用途
公开(公告)号：WO2006062981A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044140
申请日：2005-12-07
Applicant: ABBOTT LABORATORIES , LEE, Chih-Hung , BROWN, Brian, S. , KEDDY, Ryan, G. , PERNER, Richard, J. , KOENIG, John, R.
Inventor： LEE, Chih-Hung , BROWN, Brian, S. , KEDDY, Ryan, G. , PERNER, Richard, J. , KOENIG, John, R.
CPC classification number: C07D471/04
Abstract: Compounds having formula (I) or formula (II), or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A, N, X, Y, R 1 , R 2 and R 3 are as defined in the specification. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.
Abstract translation: 具有式（I）或式（II）的化合物或其药学上可接受的盐，前药或其前体药物的盐，其中A，N，X，Y，R 1， 2＆lt;＆gt;和R 3＆gt;如说明书中所定义。 这些化合物特别可用于治疗疼痛，炎性痛觉过敏和尿功能障碍，例如膀胱过度活动和尿失禁。
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19.发明申请FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 审中-公开抑制VANILLOID受体亚型1（VR1）受体的融合化合物
公开(公告)号：WO2004111009A1
公开(公告)日：2004-12-23
申请号：PCT/US2004/018590
申请日：2004-06-10
Applicant: ABBOTT LABORATORIES , GOMTSYAN, Arthur , BAYBURT, Erol, K. , LEE, Chih-Hung , KOENIG, John, R. , SCHMIDT, Robert , LUKIN, Kirill , CHAMBOURNIER, Gilles , HSU, Margaret , LEANNA, M., Robert , CINK, Russel, D.
Inventor： GOMTSYAN, Arthur , BAYBURT, Erol, K. , LEE, Chih-Hung , KOENIG, John, R. , SCHMIDT, Robert , LUKIN, Kirill , CHAMBOURNIER, Gilles , HSU, Margaret , LEANNA, M., Robert , CINK, Russel, D.
IPC: C07D217/02
CPC classification number: C07D403/12 , C07D217/02 , C07D231/56 , C07D401/12
Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.
Abstract translation: 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X1-X5，R5-R8b，Z1-Z2和Ar1如本文所定义），一种抑制VR1受体的方法 使用这些化合物的哺乳动物，用于控制哺乳动物疼痛的方法，以及包括这些化合物的药物组合物和制备这些化合物的方法。
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20.发明申请TRISUBSTITUTED-N-[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS 审中-公开N - [（1S）-1,2,3,4-四氢-1H-萘并]含有受体的P2X3和P2X2 / 3的苯并噻唑
公开(公告)号：WO2002094767A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/015174
申请日：2002-05-14
Applicant: ABBOTT LABORATORIES
Inventor： LEE, Chih-Hung , PERNER, Richard, J. , LARSON, Daniel, P. , KOENIG, John, R. , GOMTSYAN, Arthur, R. , ZHENG, Guo Zhu , DIDOMENICO, Stanley , STEWART, Andrew, O. , BAYBURT, Erol, K.
IPC: C07C233/74
CPC classification number: C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
Abstract: Compounds of formula (I), are novel P2X 3 and P2X 2 /P2X 3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
Abstract translation: 式（I）化合物是可用于治疗疼痛，尿失禁和膀胱过度活动的新型P2X> 3和P2X> 2 3拮抗剂。
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