公开(公告)号：WO2002094767A2

公开(公告)日：2002-11-28

申请号：PCT/US2002/015174

申请日：2002-05-14

Applicant: ABBOTT LABORATORIES

Inventor： LEE, Chih-Hung ,  PERNER, Richard, J. ,  LARSON, Daniel, P. ,  KOENIG, John, R. ,  GOMTSYAN, Arthur, R. ,  ZHENG, Guo Zhu ,  DIDOMENICO, Stanley ,  STEWART, Andrew, O. ,  BAYBURT, Erol, K.

IPC: C07C233/74

CPC classification number: C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/72

Abstract: Compounds of formula (I), are novel P2X 3 and P2X 2 /P2X 3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.

Abstract translation: 式（I）化合物是可用于治疗疼痛，尿失禁和膀胱过度活动的新型P2X> 3和P2X> 2 3拮抗剂。

公开(公告)号：WO2005019191A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/027000

申请日：2004-08-19

Applicant: ABBOTT LABORATORIES ,  HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

Inventor： HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

IPC: C07D285/00

CPC classification number: C07D417/12 ,  C07D285/24 ,  C07D285/30 ,  C07D513/04

Abstract: Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Abstract translation: 具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。

公开(公告)号：WO2004083207A1

公开(公告)日：2004-09-30

申请号：PCT/US2003/007689

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。

公开(公告)号：EP1631570A1

公开(公告)日：2006-03-08

申请号：EP03723732.8

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04 ,  A61K31/435 ,  A61P31/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1392643B1

公开(公告)日：2005-09-14

申请号：EP02739257.0

申请日：2002-05-14

Applicant: ABBOTT LABORATORIES

Inventor： LEE, Chih-Hung ,  PERNER, Richard, J. ,  LARSON, Daniel, P. ,  KOENIG, John, R. ,  GOMTSYAN, Arthur, R. ,  ZHENG, Guo Zhu ,  DIDOMENICO, Stanley ,  STEWART, Andrew, O. ,  BAYBURT, Erol, K.

IPC: C07C233/74 ,  A61K31/166 ,  A61K31/18 ,  A61P21/00

CPC classification number: C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/72

Abstract: Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.

Abstract translation: 式（I）化合物是新型P2X3和P2X2 / P2X3拮抗剂，其可用于治疗疼痛，尿失禁和膀胱过度活动。

公开(公告)号：EP1392643A2

公开(公告)日：2004-03-03

申请号：EP02739257.0

申请日：2002-05-14

Applicant: Abbott Laboratories

Inventor： LEE, Chih-Hung ,  PERNER, Richard, J. ,  LARSON, Daniel, P. ,  KOENIG, John, R. ,  GOMTSYAN, Arthur, R. ,  ZHENG, Guo Zhu ,  DIDOMENICO, Stanley ,  STEWART, Andrew, O. ,  BAYBURT, Erol, K.

IPC: C07C233/74 ,  A61K31/166 ,  A61K31/18 ,  A61P21/00

CPC classification number: C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/72

Abstract: Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.