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1.发明申请TRISUBSTITUTED-N-[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS 审中-公开N - [（1S）-1,2,3,4-四氢-1H-萘并]含有受体的P2X3和P2X2 / 3的苯并噻唑
公开(公告)号：WO2002094767A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/015174
申请日：2002-05-14
Applicant: ABBOTT LABORATORIES
Inventor： LEE, Chih-Hung , PERNER, Richard, J. , LARSON, Daniel, P. , KOENIG, John, R. , GOMTSYAN, Arthur, R. , ZHENG, Guo Zhu , DIDOMENICO, Stanley , STEWART, Andrew, O. , BAYBURT, Erol, K.
IPC: C07C233/74
CPC classification number: C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
Abstract: Compounds of formula (I), are novel P2X 3 and P2X 2 /P2X 3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
Abstract translation: 式（I）化合物是可用于治疗疼痛，尿失禁和膀胱过度活动的新型P2X> 3和P2X> 2 3拮抗剂。
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Patent Agency Ranking2.发明申请NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS 审中-公开新的取代的OCTAHYDROCYCLOPENTA [C]吡咯烷-4-胺作为钙通道阻断剂
公开(公告)号：WO2011149995A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037820
申请日：2011-05-24
Applicant: ABBOTT LABORATORIES , SEARLE, Xenia, B. , YEUNG, Ming, C. , DIDOMENICO, Stanley , STEWART, Andrew, O. , DARCZAK, Daria , SCHRIMPF, Michael, R. , ROZEMA, Michael, J.
Inventor： SEARLE, Xenia, B. , YEUNG, Ming, C. , DIDOMENICO, Stanley , STEWART, Andrew, O. , DARCZAK, Daria , SCHRIMPF, Michael, R. , ROZEMA, Michael, J.
IPC: C07D209/52 , A61K31/404 , A61P29/00
CPC classification number: C07D209/52 , C07D209/02 , C07D209/44
Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L 1 , L 2 , R 1 , R 2 , and R 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本申请涉及含有式（I）化合物的钙通道抑制剂，其中L1，L2，R1，R2和R3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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3.发明申请NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS 审中-公开新的取代的OCTAHYDROCYCLOPENTA（C）PYRROL-4-氨基酸作为钙通道阻断剂
公开(公告)号：WO2010062927A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/065847
申请日：2009-11-25
Applicant: ABBOTT LABORATORIES , STEWART, Andrew , SEARLE, Xenia , DARCZAK, Daria , YEUNG, Ming , DIDOMENICO, Stanley
Inventor： STEWART, Andrew , SEARLE, Xenia , DARCZAK, Daria , YEUNG, Ming , DIDOMENICO, Stanley
IPC: C07D209/02 , A61K31/403
CPC classification number: C07D209/02
Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I), wherein L 1 , L 2 , R 1 , R 2 , and R 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本申请涉及含有式（I）化合物的钙通道抑制剂，其中L1，L2，R1，R2和R3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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4.发明公开SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS 审中-公开取代基OCTAHYDROCYCLOPENTA（C）PYRROL-4-胺ALS钙离子保护剂
公开(公告)号：EP2367790A2
公开(公告)日：2011-09-28
申请号：EP09764953.7
申请日：2009-11-25
Applicant: Abbott Laboratories
Inventor： STEWART, Andrew , SEARLE, Xenia , DARCZAK, Daria , YEUNG, Ming , DIDOMENICO, Stanley
IPC: C07D209/02 , A61K31/403
CPC classification number: C07D209/02
Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I), wherein L
1 , L
2 , R
1 , R
2 , and R
3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.-
5.发明授权TRISUBSTITUTED-N- (1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS 有权（1S）-1,2,3,4-四氢-1-萘酰基]苯甲酰胺类化合物，其抑制含P2X3和P2X2 / 3的受体
公开(公告)号：EP1392643B1
公开(公告)日：2005-09-14
申请号：EP02739257.0
申请日：2002-05-14
Applicant: ABBOTT LABORATORIES
Inventor： LEE, Chih-Hung , PERNER, Richard, J. , LARSON, Daniel, P. , KOENIG, John, R. , GOMTSYAN, Arthur, R. , ZHENG, Guo Zhu , DIDOMENICO, Stanley , STEWART, Andrew, O. , BAYBURT, Erol, K.
IPC: C07C233/74 , A61K31/166 , A61K31/18 , A61P21/00
CPC classification number: C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
Abstract: Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
Abstract translation: 式（I）化合物是新型P2X3和P2X2 / P2X3拮抗剂，其可用于治疗疼痛，尿失禁和膀胱过度活动。
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6.发明公开TRISUBSTITUTED-N- (1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS 有权三取代-N - （（1S）-1,2,3,4-四氢-1-萘基）苯甲酰胺WHAT P2X3和P2X2 / 3 CONTAINING受体INHIBIT
公开(公告)号：EP1392643A2
公开(公告)日：2004-03-03
申请号：EP02739257.0
申请日：2002-05-14
Applicant: Abbott Laboratories
Inventor： LEE, Chih-Hung , PERNER, Richard, J. , LARSON, Daniel, P. , KOENIG, John, R. , GOMTSYAN, Arthur, R. , ZHENG, Guo Zhu , DIDOMENICO, Stanley , STEWART, Andrew, O. , BAYBURT, Erol, K.
IPC: C07C233/74 , A61K31/166 , A61K31/18 , A61P21/00
CPC classification number: C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
Abstract: Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
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