公开(公告)号：WO1996020187A3

公开(公告)日：1996-07-04

申请号：PCT/US1995016779

申请日：1995-12-21

Applicant: ALCON LABORATORIES, INC. ,  HELLBERG, Mark ,  GRAFF, Gustav ,  GAMACHE, Daniel, A. ,  NIXON, Jon, C. ,  GARNER, William, H.

Inventor： ALCON LABORATORIES, INC.

IPC: C07D311/72

公开(公告)号：WO1996014829A1

公开(公告)日：1996-05-23

申请号：PCT/US1995014910

申请日：1995-11-16

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DESAI, Suketu, Dipakbhai ,  NELMS, Diane, S.

IPC: A61K09/00

CPC classification number: A61K47/32 ,  A61K9/0048 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914 ,  Y10S514/954

Abstract: Disclosed are storage-stable preserved ophthalmic compositions containing acidic drugs in combination with polymeric quaternary ammonium compounds and boric acid.

Abstract translation: 公开了含有与聚合季铵化合物和硼酸组合的酸性药物的保存稳定的防腐眼用组合物。

公开(公告)号：WO1996010425A1

公开(公告)日：1996-04-11

申请号：PCT/US1995011471

申请日：1995-09-19

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  PARK, Joonsup

IPC: A61L02/00

CPC classification number: A01N33/12 ,  A61L12/145 ,  C08G65/33303 ,  Y10S514/839 ,  Y10S514/84

Abstract: PEO-containing quaternary ammonium compounds have good broad spectrum antimicrobial activity. These compounds are useful in pharmaceutical compositions as preservatives and in contact lens care compositions as preservatives and/or disinfectants.

Abstract translation: 含PEO的季铵化合物具有良好的广谱抗菌活性。 这些化合物可用作药物组合物作为防腐剂和隐形眼镜护理组合物作为防腐剂和/或消毒剂。

公开(公告)号：WO1996006597A1

公开(公告)日：1996-03-07

申请号：PCT/US1995010877

申请日：1995-08-23

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  KABRA, Bhagwati, P. ,  LANG, John, C.

IPC: A61K09/00

CPC classification number: A61K9/0048 ,  A61K47/38 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914

Abstract: Drug delivery vehicles which reversibly increase in either loss modulus or storage modulus, or both, upon contact with the eye, skin, mucous membrane or body cavity are disclosed. The vehicles contain one or more nonionic substituted cellulose ethers and do not require a charged sufactant or a pH-sensitive polymer for such increase in loss modulus or storage modulus, or both, upon administration. In one embodiment, the vehicles gel upon instillation in the eye.

Abstract translation: 公开了与眼睛，皮肤，粘膜或体腔接触时可逆地增加损失模量或储能模量或两者的药物递送载体。 载体含有一种或多种非离子取代的纤维素醚，并且在给药时不需要带电荷的表面活性剂或pH敏感性聚合物来增加损失模量或储能模量，或两者。 在一个实施方案中，车辆在滴眼时凝胶化。

公开(公告)号：WO1995019981A1

公开(公告)日：1995-07-27

申请号：PCT/US1995000775

申请日：1995-01-20

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  MAY, Jesse, Albert ,  CHEN, Hwang-Hsing ,  DUPRE, Brian ,  DEAN, Thomas, R.

IPC: C07D513/04

CPC classification number: C07D513/04 ,  C07D333/34

Abstract: New carbonic anhydrase inhibitors of formula (I) and methods for their use are disclosed. G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from formula (a) or (b).

Abstract translation: 公开了式（I）的新型碳酸酐酶抑制剂及其使用方法。 G，J和它们所连接的噻吩环的两个原子形成选自式（a）或（b）的六元环。

公开(公告)号：WO1994025426A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004428

申请日：1994-04-22

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DASSANAYAKE, Nissanke, L. ,  SCHLITZER, Ronald, L. ,  PARK, Joonsup ,  ASGHARIAN, Bahram

IPC: C07C211/10

CPC classification number: C07C211/25 ,  A01N33/04 ,  A01N33/08 ,  A61L12/14 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C211/21 ,  C07C215/14 ,  Y10S514/839 ,  Y10S514/84

Abstract: Certain N,N-dialkyl, N'-alkylethylene diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

Abstract translation: 描述了某些N，N-二烷基，N'-烷基乙烯二胺，其用于消毒和清洁隐形眼镜和保存眼用产品以及相关眼用组合物。

公开(公告)号：WO1994004143A1

公开(公告)日：1994-03-03

申请号：PCT/US1993007759

申请日：1993-08-17

Applicant: ALCON LABORATORIES, INC. ,  CONROW, Raymond, E. ,  CLARK, Abbot, F.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K31/325

CPC classification number: C07D285/08 ,  A61K31/045 ,  A61K31/075 ,  A61K31/095 ,  A61K31/10 ,  A61K31/11 ,  A61K31/12 ,  A61K31/16 ,  A61K31/19 ,  A61K31/255 ,  A61K31/27 ,  A61K31/275 ,  A61K31/41 ,  A61K31/415 ,  A61K31/66 ,  C07C235/26 ,  C07C271/38 ,  C07C309/73 ,  C07C317/18 ,  C07C323/52 ,  C07C2602/24 ,  C07D233/84

Abstract: Substituted hydrindanes, particularly of formula (I) in which X, Y, R4, R5, R6, R7 and R8 are as defined in the description, and their use in controlling angiogenesis dependent diseases in warm blooded animals, as well as a method for preparing 3-bromo-(2,2-dimethyl)propyl benzoate are disclosed.

Abstract translation: 取代的氢化茚，特别是其中X，Y，R 4，R 5，R 6，R 7和R 8如说明书中所定义的式（I）化合物及其在控制温血动物中血管生成依赖性疾病中的用途，以及用于 公开了制备3-溴 - （2,2-二甲基）丙基苯甲酸酯。

公开(公告)号：WO1993010141A2

公开(公告)日：1993-05-27

申请号：PCT/US1992010133

申请日：1992-11-23

Applicant: ALCON LABORATORIES, INC. ,  CLARK, Abbot, F. ,  CONROW, Raymond, E.

Inventor： ALCON LABORATORIES, INC.

IPC: C07J05/00

CPC classification number: A61K31/573 ,  A61K31/56 ,  A61K31/565 ,  A61K31/569 ,  A61K31/57 ,  A61K31/58 ,  A61K31/665 ,  C07J3/00 ,  C07J5/0053 ,  C07J9/00 ,  C07J11/00 ,  C07J41/0005 ,  C07J41/0027 ,  C07J51/00 ,  A61K2300/00

Abstract: Angiostatic steroids for use in controlling neovascularization and ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating neovascularization and ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated intraocular pressure during the treatment of inflammation is disclosed.

Abstract translation: 公开了用于控制新生血管形成和高眼压症的止血类固醇。 公开了血管抑制类固醇的药物组合物及其用于治疗新生血管形成和高眼压症的方法，包括控制与原发性开角型青光眼相关的眼压高血压。 此外，公开了化合物与糖皮质激素的组合以防止炎症治疗期间眼内压升高。

公开(公告)号：WO1990002555A1

公开(公告)日：1990-03-22

申请号：PCT/US1989004002

申请日：1989-09-15

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CHOWHAN, Masood, A. ,  HELTON, Danny, O. ,  HARRIS, R., Gregg ,  LUTHY, Connie, L.

IPC: A61K31/74

CPC classification number: C11D3/48 ,  A61L12/145 ,  C11D3/0078 ,  C11D3/2086 ,  C11D3/3723 ,  Y10S514/839 ,  Y10S514/912

Abstract: Hypotonic contact lens care compositions containing a quaternary ammonium antimicrobial agent (e.g. PolyquadR) and an anionic complexing agent (e.g. citrate) are disclosed. The compositions are useful in the disinfection of hydrophilic contact lenses, particularly Group IV lenses, and in the preservation of products for treating such lenses. Methods for use of the compositions for disinfecting and preserving are also disclosed.

公开(公告)号：WO1990001933A1

公开(公告)日：1990-03-08

申请号：PCT/US1989003648

申请日：1989-08-24

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CAGLE, Gerald, D.

IPC: A61K31/56

CPC classification number: A61K9/0048 ,  A61K31/57 ,  A61K31/495 ,  A61K2300/00

Abstract: Disclosed are pharmaceutical compositions containing a quinolone antibiotic, such as ciprofloxacin, and a steroid, such as rimexolone, dexamethasone, fluorometholone or fluorometholone acetate, and the like for topical ophthalmic delivery, and a method of treatment comprising administering said compositions topically to the affected ocular tissue when indicated for control of infection and associated inflammation.

Abstract translation: 本发明公开了含有喹诺酮类抗生素（如环丙沙星）和类固醇（如雷米洛尔，地塞米松，氟孕酮或醋酸氟米隆）等用于局部眼科输送的药物组合物，以及治疗方法，包括将所述组合物局部施用于受影响的眼部 指示用于控制感染和相关炎症时的组织。