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公开(公告)号：CA2611083A1
公开(公告)日：2006-12-14
申请号：CA2611083
申请日：2006-05-31
Applicant: BASF AG
Inventor： KOLTER KARL , SCHOENHERR MICHAEL , ASCHERL HERMANN
IPC: A61K9/14 , A23L33/15 , A61K9/16 , A61K9/26 , A61K9/48 , A61K31/07 , A61K31/405 , A61K31/4174 , A61K31/426 , A61K31/495 , A61K31/496 , A61K31/5415 , A61K31/55
Abstract: A process for producing solid solutions in powder or granule form of slightly soluble substances in which the slightly soluble substance is in the form of a molecular dispersion in an excipient matrix, by atomizing a solution of the active ingredient and of the matrix excipients, which comprises heating an aqueous suspension of the slightly soluble substance in the presence of the matrix excipients to temperatures above the boiling point under atmospheric pressure, and dissolving the slightly soluble substance, and subsequently converting the solution of the slightly soluble substance and of the matrix excipients by atomizing and drying into a solid form, where the temperature of the spray solution before feeding into the atomizing apparatus is 90° C. to 350° C.
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公开(公告)号：HU0201286A2
公开(公告)日：2002-09-28
申请号：HU0201286
申请日：2000-03-05
Applicant: BASF AG
Inventor： ASCHERL HERMANN , HARMS GUIDO , KREI GEORG ARNOLD , DR SCHAEFER BERND
Abstract: The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula Iwhere n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried.
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公开(公告)号：BR0010440A
公开(公告)日：2002-02-19
申请号：BR0010440
申请日：2000-05-03
Applicant: BASF AG
Inventor： SCHOFER BERND , HARMS GUIDO , ASCHERL HERMANN , KREI GEORG ARNOLD
IPC: C12N9/99 , A61K38/00 , A61P7/02 , A61P9/00 , A61P25/00 , A61P35/00 , C07K5/065 , C07K5/06 , C07K1/14 , A61K31/40 , A61K31/44
Abstract: The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula Iwhere n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried.
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公开(公告)号：DE10015479A1
公开(公告)日：2001-10-11
申请号：DE10015479
申请日：2000-03-29
Applicant: BASF AG
Inventor： KOLTER KARL , SCHOENHERR MICHAEL , ASCHERL HERMANN
IPC: A61K47/32 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/28 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/34 , A61K47/38 , A61P3/02 , A61K9/52
Abstract: The present invention relates to oral dosage forms with delayed release of active ingredient and high mechanical stability, comprising a) one or more active ingredients b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone c) water-soluble polymers or low or high molecular weight lipophilic additives d) and other conventional excipients, and to the use and production thereof.
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公开(公告)号：DE19921346A1
公开(公告)日：2000-11-16
申请号：DE19921346
申请日：1999-05-10
Applicant: BASF AG
Inventor： SCHAEFER BERND , HARMS GUIDO , ASCHERL HERMANN , KREI GEORG ARNOLD
Abstract: The invention relates to a method for producing thrombin inhibitors which have a constant weight and which are of formula (I), whereby n represents 0, 1, 2 and tautomers thereof, whereby an aqueous solution of the active substance is spray dried.
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Patent Agency Ranking
公开(公告)号：BRPI0611056B1
公开(公告)日：2015-12-15
申请号：BRPI0611056
申请日：2006-06-02
Applicant: BASF AG
Inventor： EICHFELDER ANDREAS , SIEDER GEORG , SCHERR GÜNTER , ASCHERL HERMANN , SCHNEIDER JÖRG , CIPRIAN JÜRGEN , REIF MARTIN , EHRHARDT RAINER , HIRSCH STEFAN , HOLTMANN THOMAS
IPC: C07D251/70
Abstract: processo para a elaboração de uma mistura de reação alcanólica. a invenção refere-se a um processo para o tratamento de uma istura de reação alcoólica produzida durante a preparação de lcoxicarbonilaminotriazinas e compreendendo pelo menos uma alcoxicarbonilaminotriazina, pelo menos um éster carbônico cíclico e/ou acíclico, pelo menos um c~1~-c~13~ alcanol, que opcionalmente compreende um ou dois átomos de oxigénio na forma de ligações de éter, e é opcionalmente substituído por c~1~-c~4~ alquil e/ou hidroxila, e pelo menos um alcóxido de metal alcalino ou alcóxido de metal alcalino terroso, com ou sem melamina e com ou sem catalisador, no qual os componentes polares e/ou iônicos são removidos por extração com um extrator polar que não é completamente miscível com a fase orgânica presente na mistura de reação, dando uma fase alcoólica compreendendo pelo menos uma alcoxicarbonilaminotriazina, e uma fase polar compreendendo um extrator com componentes polares e/ou iônicos dissolvidos nele.
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公开(公告)号：BRPI0611354B1
公开(公告)日：2015-09-15
申请号：BRPI0611354
申请日：2006-05-31
Applicant: BASF AG
Inventor： EICHFELDER ANDREAS , SIEDER GEORG , SCHERR GÜNTER , ASCHERL HERMANN , SCHNEIDER JÖRG , CIPRIAN JÜRGEN , REIF MARTIN , EHRHARDT RAINER , HIRSCH STEFAN , HOLTMANN THOMAS
IPC: C07D251/70
Abstract: processo para a preparação de alcoxicarbonilaminotriazina pulverulenta de fluxo livre. a invenção refere-se a um processo para a preparação de alcoxicarbonilaminotriazina pulverulenta, de fluxo livre, a partir de uma mistura de reação alcoólica, produzida durante a preparação de alcoxicarbonilaminotriazinas e compreendendo pelo menos uma alcoxicarbonilaminotriazina, pelo menos um éster de ácido carbônico cíclico e/ou acíclico, e pelo menos um alcanol c~1~-~13~, opcionalmente contendo um ou dois átomos de oxigênio como uma ligação éter e opcionalmente substituído por alquila c~1~-c~4~ e/ou hidróxi e pelo menos um alcóxido de metal alcalino ou alcalino terroso, de modo opcional melamina e opcionalmente um catalisador, caracterizado pelo fato de que a mistura da reação é atomizada e secada em um secador por pulverização.
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公开(公告)号：BRPI0611241A2
公开(公告)日：2010-12-07
申请号：BRPI0611241
申请日：2006-06-01
Applicant: BASF AG
Inventor： SCHERR GUENTER , ERHARDT RAINER , EICHFELDER ANDREAS , REIF MARTIN , HIRSCH STEFAN , SIEDER GEORG , HOLTMANN THOMAS , CIPRIAN JUERGEN , ASCHERL HERMANN , SCHNEIDER JOERG
IPC: C07D251/70
Abstract: The invention relates to a process for removing salts from an alkanolic reaction mixture which is obtained in the preparation of alkoxycarbonylaminotriazines and comprises at least one alkoxycarbonylaminotriazine, at least one cyclic and/or acyclic carbonic ester, at least one C 1 -C 13 -alkanol which optionally comprises one or two oxygen atoms as ether bonds and is optionally substituted by C 1 -C 4 -alkyl and/or hydroxyl, and also at least one alkali metal alkoxide or alkaline earth metal alkoxide, with or without melamine and with or without catalyst, in which salts are removed from the reaction mixture by ion exchange over a cation exchanger and/or anion exchanger.
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公开(公告)号：DE102005026755A1
公开(公告)日：2006-12-14
申请号：DE102005026755
申请日：2005-06-09
Applicant: BASF AG
Inventor： KOLTER KARL , SCHOENHERR MICHAEL , ASCHERL HERMANN
Abstract: A process for producing solid solutions in powder or granule form of slightly soluble substances in which the slightly soluble substance is in the form of a molecular dispersion in an excipient matrix, by atomizing a solution of the active ingredient and of the matrix excipients, which comprises heating an aqueous suspension of the slightly soluble substance in the presence of the matrix excipients to temperatures above the boiling point under atmospheric pressure, and dissolving the slightly soluble substance, and subsequently converting the solution of the slightly soluble substance and of the matrix excipients by atomizing and drying into a solid form, where the temperature of the spray solution before feeding into the atomizing apparatus is 90° C. to 350° C.
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公开(公告)号：DE50105229D1
公开(公告)日：2005-03-10
申请号：DE50105229
申请日：2001-05-12
Applicant: BASF AG
Inventor： KOLTER DR , FLICK DIETER , ASCHERL HERMANN
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