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公开(公告)号:JP2000344794A
公开(公告)日:2000-12-12
申请号:JP2000137517
申请日:2000-05-10
Applicant: BASF AG
Inventor: SCHAEFER BERND
IPC: C12N9/99 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/55 , A61P1/18 , A61P7/02 , A61P11/06 , A61P19/02 , A61P27/16 , A61P29/00 , A61P35/04 , A61P43/00 , C07K5/065 , C07K5/078
Abstract: PROBLEM TO BE SOLVED: To obtain a new compound which is a stably preservable thrombin inhibitor and is useful for producing a medicine having an antithrombotic action. SOLUTION: This compound is shown by formula I or formula II (n is 0.5, 1 or 2; HX is a group of formula III substitutable with methyl, etc., at one or two positions or the like) such as N-((hydroxycarbonyl)-methylene)-(R)- cyclohexylalanyl-(S)-3,4-dehydroproline-(6-amidino-3-picolinyl)-amido- saccharin salt. The compound of formula I or formula II is obtained by a method for reacting an inorganic acid salt or a 1-4C carboxylate [e.g. N-((hydroxycarbonyl)- methylene)-(R)-cyclohexylalanyl-(S)-3,4-dehydroproline-(6-amidino-3-pi colinyl)- amido-hydrochloride, etc.], of an action substance of formula I or formula II with an alkali metal salt of a compound of the formula HX (e.g. saccharin- sodium salt) in water as a preferable method.
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公开(公告)号:WO9209575A2
公开(公告)日:1992-06-11
申请号:PCT/EP9102166
申请日:1991-11-16
Applicant: BASF AG
Inventor: RUEB LOTHAR , EICKEN KARL , SCHAEFER BERND , REISSENWEBER GERNOT , SCHAEFER PETER
IPC: C07C205/56 , C07C229/40 , C07D209/48
CPC classification number: C07D209/48
Abstract: The invention concerns the preparation of 3-(3,4,5,6-tetrahydrophthalimido)cinnamic acid esters of formula (I) (R1 = H, halogen; R2, R3 = halogen; R4 = C-organic rest; R5 = H, CH¿3?) by the reduction of 3-nitrocinnamic acid esters of formula (II) with hydrogen in the presence of a catalyst and the condensation of the 3-aminocinnamic acid esters obtained of formula (III) with a 3,4,5,6-tetrahydrophthalic acid anhydride of formula (IV). 3-(3,4,5,6-tetrahydrophthalimido)cinnamic acid esters of formula (I) are useful active agents in the plant-protection field.
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公开(公告)号:ZA200200459B
公开(公告)日:2004-05-26
申请号:ZA200200459
申请日:2002-01-18
Applicant: BASF AG
Inventor: KNOPP MONIKA , KOSER STEFAN , SCHAEFER BERND
IPC: C07D277/20 , C07D277/56 , C07D
Abstract: The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ibin whichn=1 or 2 andfor n=1, X is chloride, bromide, triflate and hydrogen sulfate andfor n=2, X is sulfate, which comprises the process step where the aminonitrile of the formula IIis stirred with a cysteine ester of the formula III,in which R is branched or linear C1-10-alkyl orwhere n=0, 1 or 2 and R is branched or linear C1-C10C10-alkyl or C1-C4-alkoxy or C1-C4-dialkylamino in an inert solvent in the presence of a base at from 0° C. to 80° C. until the reaction has essentially proceeded to completion, and to the compounds of the formulae Ia and Ib.
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公开(公告)号:FI111543B
公开(公告)日:2003-08-15
申请号:FI961680
申请日:1996-04-17
Applicant: BASF AG
Inventor: SCHAEFER BERND , MAYER HORST
IPC: C07D251/46 , B01J27/122 , B01J27/138 , B01J31/04 , B01J31/22 , C07D251/16
Abstract: PCT No. PCT/EP94/03331 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Oct. 10, 1994 PCT Pub. No. WO95/11237 PCT Pub. Date Apr. 27, 1995A process for preparing asymmetrically substituted triazines of the formula I I where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II II with a carboxylic acid derivative in the presence of an alcohol of the formula III R2-OHIII,which comprises reacting a carboxylic acid ester of the formula IV R3-COOR4IV,where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
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公开(公告)号:ZA200107629B
公开(公告)日:2002-09-17
申请号:ZA200107629
申请日:2001-09-17
Applicant: BASF AG
Inventor: SCHAEFER BERND , HELMCHEN GUENTER , KAZMAIER ULI , SCHLEICH SIMONE , STAHR HELMUT , WOLFART VOLKER
IPC: C07D211/78 , C07D207/16 , C07D207/20 , C07D211/70 , C07D
Abstract: A process for preparing compounds of the formula Iin whichR is hydrogen, C1-C6-alkoxy, -NHC1-C6-alkyl, -N(C1-C6-alkyl)2, OH, NH2R1 is hydrogen, C1-C6-alkyl, Me3Si, C1-C6-alkyl-SR2 is Boc, C1-C6-acyl, mesyl, benzenesulfonyl, tosyl, trifluoroacetyl, A1-A3-peptiden is 1, 2R4 is H, C1-C6-alkyl,is described.
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公开(公告)号:DE10040051A1
公开(公告)日:2002-02-21
申请号:DE10040051
申请日:2000-08-11
Applicant: BASF AG
Inventor: SCHAEFER BERND , GENESTE HERVE
IPC: C07C37/00 , C07C37/50 , C07C39/24 , C07C45/00 , C07C45/60 , C07C47/565 , C07C49/825 , C07C51/15 , C07C65/05 , C07D309/12 , C07F5/02 , C07F7/08 , C07C47/273 , C07F5/04 , C07C69/88 , C07C323/20
Abstract: The invention relates to a method for producing 2- and 2,5-substituted derivatives of 4-(trifluoromethyl)-phenol and 4-(2-trifluoromethyl)-phenyl)-2-tetrahydropyranyl) ether and to novel derivatives. Said method is characterised in that a compound of formula (2) 4-(trifluoromethylphenyl)-2-(tetrahydropyranyl) ether is reacted with an electrophile E-X or a combination of electrophiles E-X and E-Y in the presence of a base, X and Y having the meanings given in the description.
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公开(公告)号:NO20015465L
公开(公告)日:2001-11-09
申请号:NO20015465
申请日:2001-11-08
Applicant: BASF AG
Inventor: SCHAEFER BERND , HARMS GUIDO , ASCHERL HERMANN , KREI GEORG ARNOLD
IPC: C12N9/99 , A61K38/00 , A61P7/02 , A61P9/00 , A61P25/00 , A61P35/00 , C07K5/065 , C07K1/14 , A61K38/05
Abstract: The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula Iwhere n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried.
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公开(公告)号:ZA9807239B
公开(公告)日:2000-02-14
申请号:ZA9807239
申请日:1998-08-13
Applicant: BASF AG
Inventor: BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHAEFER BERND , THYES MARCO , HOEGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14 , C07D , A61K
CPC classification number: C07D239/56
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公开(公告)号:DK0668852T3
公开(公告)日:1998-03-16
申请号:DK94900087
申请日:1993-11-02
Applicant: BASF AG
Inventor: KLINTZ RALF , KIRSTGEN REINHARD , THEOBALD HANS , OBERDORF KLAUS , DOETZER REINHARD , SCHAEFER BERND , HARRIES VOLKER , KARDORFF UWE , LORENZ GISELA , AMMERMANN EBERHARD
IPC: A01N37/06 , A01N37/10 , A01N37/30 , A01N37/34 , A01N37/36 , A01N37/50 , A01N43/40 , A01N43/72 , A01N43/80 , A01N43/824 , C07C69/34 , C07C69/65 , C07C69/734 , C07C69/738 , C07C205/42 , C07C205/53 , C07C205/56 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/72 , C07C239/20 , C07C239/22 , C07C243/32 , C07C243/38 , C07C251/40 , C07C251/48 , C07C251/52 , C07C251/64 , C07C251/66 , C07C255/14 , C07C255/38 , C07C255/41 , C07C255/62 , C07C255/64 , C07C255/66 , C07C259/06 , C07C271/60 , C07C291/02 , C07C323/10 , C07C323/62 , C07C327/20 , C07C327/38 , C07C331/02 , C07D295/32
Abstract: PCT No. PCT/EP93/03067 Sec. 371 Date May 12, 1995 Sec. 102(e) Date May 12, 1995 PCT Filed Nov. 12, 1993 PCT Pub. No. WO94/11334 PCT Pub. Date May 26, 1994Compounds of the formula I where the index and the substituents have the following meanings as defined in the specification.
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公开(公告)号:AT158281T
公开(公告)日:1997-10-15
申请号:AT94928883
申请日:1994-10-10
Applicant: BASF AG
Inventor: SCHAEFER BERND , MAYER HORST
IPC: C07D251/46 , B01J27/122 , B01J27/138 , B01J31/04 , B01J31/22 , C07D251/16
Abstract: PCT No. PCT/EP94/03331 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Oct. 10, 1994 PCT Pub. No. WO95/11237 PCT Pub. Date Apr. 27, 1995A process for preparing asymmetrically substituted triazines of the formula I I where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II II with a carboxylic acid derivative in the presence of an alcohol of the formula III R2-OHIII,which comprises reacting a carboxylic acid ester of the formula IV R3-COOR4IV,where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
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