Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing a granule containing an active component, having good physical properties, continuously releasing active components by tableting and convertible to a high-dose pharmaceutical preparation having good mechanical properties. SOLUTION: The method for the production of a solid peroral preparation continuously releasing the active component comprises the use of at least one kind of active component, a mixture of polyvinyl acetate and polyvinyl pyrrolidone, optionally a water-soluble polymer or an oleophilic additive and optionally other conventional excipient as the components of the preparation, the granulation of the mixture of at least a part of the above components by heating at 40-130 deg.C, the mixing of the obtained granule with conventional excipient and the tableting of the mixture.
Abstract:
PROBLEM TO BE SOLVED: To provide an oral administration form exhibiting a delayed active substance release and a high mechanical stability, since the method for adjusting the above releasing profile while maintaining the skeletal and mechanical stability is not publicly known. SOLUTION: This oral administration form exhibiting the delayed active substance release and the high mechanical stability is provided by incorporating a) >=1 active substance, b) a blended mixture consisting of a polyvinyl acetate and polyvinylpyrrolidone, c) a water soluble polymer, or a low molecular weight or high molecular weight lipophilic additive and d) other usually used assistants.
Abstract:
PROBLEM TO BE SOLVED: To provide an oral dosage form delayedly releasing active ingredient(s) through floating on gastric juice. SOLUTION: This oral dosage form comprises (a) one or more active ingredient(s), (b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone and (c) optionally, another excipient commonly used for producing oral dosage forms.
Abstract:
PROBLEM TO BE SOLVED: To provide a powder shape finely crushed binder useful on the production of tablets, and to provide a method for producing the same. SOLUTION: This powder shape finely crushed binder comprises a vinyl lactam polymer, having an average particle size of ≤35 μm and an apparent density of ≤0.2 g/ml. The method for producing the binder comprises spraying a vinyl lactam polymer aqueous solution having a solid content of 1 to 35 wt.% with a single liquid nozzle under a pressure of ≥8 MPa or with a double liquid nozzle under a pressure of ≥0.2 MPa, and then drying the sprayed product with a hot gas flow. COPYRIGHT: (C)2007,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To obtain a crystalline solid of the subject compound substantially not containing an additive and having virtually sufficiently low hygroscopic property. SOLUTION: This crystalline solid constituted of a glycine-N,N-diacetic acid derivative represented by formula I [R is a 1-30C alkyl or a 2-30C alkenyl, a group of formula II (A is a 1-12C alkylene bridge, etc.; M is H or an alkali metal, etc.), etc.] is produced by distilling away water content of an aqueous solution of (A) glycine-N,N-diacetic acid derivative I [R is a 1-20C alkyl or a group of formula II, etc.] as a starting substance. Crystallization is carried out by adding a crystalline component A in an amount of 0.001-50wt.%, preferably 0.01-10wt.% based on an amount of the component A in a starting substance as a nucleus for crystallization and the crystallization temperature is controlled to 10-100 deg.C, especially 40-80 deg.C. The resultant crystalline solid has a purity of 70-99.9%, especially 80-99.5% based on total amount of solid.
Abstract:
The invention relates to a method for producing acylphosphine oxide solids consisting in transforming a molten or dispersed acylphosphine oxide into the solid aggregated state thereof by means of mechanical stress, shear force or the internal motion of the melt.
Abstract:
The present invention relates to a microcapsular powder having a latent heat storage material as a capsule core and a capsule wall constructed of from 10% to 100% by weight of one or more C1-C24-alkyl esters of acrylic and/or methacrylic acid (monomers I), from 0% to 80% by weight of a water-insoluble or substantially water-insoluble bi- or polyfunctional monomer (monomers II), and from 0% to 90% by weight of other monomers (monomer III) all based on the total weight of the monomers, having an average particle size in the range of 150-400 μm and having 80% by weight of particles ≧90 μm in diameter, to a process for its production and to its use in bindered building materials, textiles and dumped beds.
Abstract:
Purify-hasty, powdered bonding agents comprises a vinyllactampolymer, where the bonding agents exhibits an average particle size of upto 35 mu m and a bulk density of smaller than 0.2 g/ml. Independent claims are included for: (1) use of the bonding agent for production of tablets with high firmness; and (2) the preparation of the bonding agents.
Abstract:
Apparatus for separating monomers from residue containing diisocyanate comprises providing a highly viscous liquid and/or a non-brittle solid material at a retention time, 210-330[deg]C and 300 hpa and removing the obtained mixture from the apparatus.
Abstract:
Separating monomers from a residue containing diisocyanate in at least an apparatus, in which the residue forms a highly viscose liquid and/or non-embrittling solid during the entire retention time in the apparatus at 210-330[deg]C and less than 300 hPa, and is forcibly discharged from the apparatus.