公开(公告)号：NO932860A

公开(公告)日：1994-02-14

申请号：NO932860

申请日：1993-08-11

Applicant: BASF AG

Inventor： KAISER KLAUS ,  BALKENHOHL FRIEDHELM ,  PAUST JOACHIM

IPC: C07F9/655 ,  C07F9/572

CPC classification number: C07F9/65515

公开(公告)号：DK0801683T3

公开(公告)日：2002-06-17

申请号：DK96900601

申请日：1996-01-20

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00

Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

公开(公告)号：DE59604905D1

公开(公告)日：2000-05-11

申请号：DE59604905

申请日：1996-09-09

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  BALKENHOHL FRIEDHELM ,  LADNER WOLFGANG

IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27

Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

公开(公告)号：DK0720655T3

公开(公告)日：2000-04-10

申请号：DK94928365

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  N BLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：DE59409010D1

公开(公告)日：2000-01-20

申请号：DE59409010

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：AT187774T

公开(公告)日：2000-01-15

申请号：AT94928365

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：ZA976637B

公开(公告)日：1999-01-25

申请号：ZA976637

申请日：1997-07-25

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C07D ,  C07B

Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II

公开(公告)号：ES2120055T3

公开(公告)日：1998-10-16

申请号：ES94919662

申请日：1994-06-24

Applicant: BASF AG

Inventor： PRESSLER UWE ,  BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  SCHNELL URSULA ,  STAUDENMAIER HORST RALF

IPC: C07D319/06 ,  C12P7/04 ,  C12P7/22 ,  C12P7/24 ,  C12P7/40 ,  C12P17/00 ,  C12P17/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/14 ,  C12R1/01 ,  C12R1/06 ,  C12R1/07 ,  C12R1/13 ,  C12R1/15 ,  C12R1/265 ,  C12R1/365 ,  C12R1/44

Abstract: PCT No. PCT/EP94/02071 Sec. 371 Date Dec. 28, 1995 Sec. 102(e) Date Dec. 28, 1995 PCT Filed Jun. 24, 1994 PCT Pub. No. WO95/02061 PCT Pub. Date Jan. 19, 1995A process for the biotechnological preparation of alcohols, aldehydes and carboxylic acids by oxidation of compounds of the formula R1-C(CH3)=CR2R3, where R1, R2 and R3 have the meanings indicated in the description, with the aid of microorganisms is described.\!

公开(公告)号：AU3694997A

公开(公告)日：1998-02-20

申请号：AU3694997

申请日：1997-07-14

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C12P17/10

Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II

公开(公告)号：CA2170059A1

公开(公告)日：1995-03-30

申请号：CA2170059

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38 ,  C12P13/00

Abstract: A process for producing optically active primary and secondary amines from the corresponding racemates is characterized in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.