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    Method for producing lipoic acid and dihydrolipoic acid
    12.
    发明专利
    Method for producing lipoic acid and dihydrolipoic acid 未知

    公开(公告)号：AU2957602A

    公开(公告)日：2002-06-11

    申请号：AU2957602

    申请日：2001-11-29

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

    IPC: C07D339/04

    Abstract: The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO 2 -R' and R and R' independently of one another are C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

    Method for producing lipoic acid and dihydrolipoic acid
    13.
    发明专利
    Method for producing lipoic acid and dihydrolipoic acid 未知

    公开(公告)号：AU9167701A

    公开(公告)日：2002-02-13

    申请号：AU9167701

    申请日：2001-07-24

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

    IPC: A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04 ,  C07D339/00

    Abstract: Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of or its stereoisomer, where Ms is SO 2 -R' and R and R' independently of one another is [sic] C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.

    16.
    发明专利
    未知

    公开(公告)号：DK169327B1

    公开(公告)日：1994-10-10

    申请号：DK234687

    申请日：1987-05-08

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG ,  LEININGER HARTMUT ,  PAUST JOACHIM

    IPC: C07B61/00 ,  B01J25/00 ,  B01J25/02 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C215/10 ,  C07C215/16 ,  C07C215/68 ,  C07H5/04

    Abstract: N-(D)-ribitylxylidine (I) is prepared by reacting (D)-ribose (II) with 3,4-dimethylaniline (III) or 3,4-dimethyl-1-nitrobenzene (IV) in aqueous or aqueous/organic solution or in solution in a water-soluble organic solvent under an elevated hydrogen pressure and in the presence of a hydrogenation catalyst and of a boric acid compound, (a) using the boric acid compound in a catalytic amount of from about 6 to 35 mmol, preferably from 6 to 20 mmol, per mol of ribose, (b) carrying out the reaction under a hydrogen pressure of from 1 to 20, preferably from 2 to 9, bar and (c) carrying out the hydrogenation at from 40 DEG to 80 DEG C. over Raney nickel as hydrogenation catalyst.

    17.
    发明专利
    未知

    公开(公告)号：DK158732B

    公开(公告)日：1990-07-09

    申请号：DK527283

    申请日：1983-11-17

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  LEININGER HARTMUT

    IPC: C07D307/33 ,  C07D307/60

    Abstract: Dihydro-4,4-dimethylfuran-2,3-dione is prepared by oxidation of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone by a process in which the oxidation is carried out by gradually adding powdered calcium oxide to a solution of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone and chlorine in the inert organic solvent.

    18.
    发明专利
    未知

    公开(公告)号：DK433689D0

    公开(公告)日：1989-09-01

    申请号：DK433689

    申请日：1989-09-01

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  ERNST HANSGEORG

    IPC: C07D239/42

    Abstract: In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I I by reacting butyramidine II II with alpha -methoxymethyl- beta -methoxyacrylonitrile III III the butyramidine II is reacted with a 0.4-5 molar excess of alpha -methoxymethyl- beta -methoxyacrylonitrile III at from -10 DEG to +20 DEG C.

    19.
    发明专利
    未知

    公开(公告)号：DK228988A

    公开(公告)日：1988-10-31

    申请号：DK228988

    申请日：1988-04-27

    Applicant: BASF AG

    Inventor： DOBLER WALTER ,  PAUST JOACHIM

    IPC: C07B61/00 ,  C07H3/02

    Abstract: Continuous process for the epimerisation of pentoses and hexoses by heating a sugar dissolved in a solvent in the presence of a basic anion exchanger loaded with a molybdenum(VI) compound, which is characterised in that, for the preparation of a D- or L-sugar with cis-OH groups in the 2- and 3-position of the sugar, a homogeneous solution of the corresponding sugar with trans-OH groups in the 2- and 3-position of the sugar is passed continuously in a mixture of water and methanol or ethanol at temperatures from 70 to 100 DEG C, preferably 73 to 80 DEG C, through a reaction tube which contains the basic anion exchanger loaded with the molybdenum(VI) compound. This process is particularly suitable for the epimerisation of D-arabinose to the D-ribose needed for the preparation of riboflavin.

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