-
公开(公告)号:CZ9904288A3
公开(公告)日:2000-03-15
申请号:CZ428899
申请日:1998-06-02
Applicant: BASF AG
Inventor: SCHAFER BERND
IPC: C07D207/20 , C07D417/12
-
公开(公告)号:ES2109016T3
公开(公告)日:1998-01-01
申请号:ES94928883
申请日:1994-10-10
Applicant: BASF AG
Inventor: SCHAFER BERND , MAYER HORST
IPC: C07D251/46 , B01J27/122 , B01J27/138 , B01J31/04 , B01J31/22 , C07D251/16
Abstract: PCT No. PCT/EP94/03331 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Oct. 10, 1994 PCT Pub. No. WO95/11237 PCT Pub. Date Apr. 27, 1995A process for preparing asymmetrically substituted triazines of the formula I I where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II II with a carboxylic acid derivative in the presence of an alcohol of the formula III R2-OHIII,which comprises reacting a carboxylic acid ester of the formula IV R3-COOR4IV,where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
-
公开(公告)号:BR9407867A
公开(公告)日:1996-10-29
申请号:BR9407867
申请日:1994-10-10
Applicant: BASF AG
Inventor: SCHAFER BERND , MAYER HORST
IPC: C07D251/46 , B01J27/122 , B01J27/138 , B01J31/04 , B01J31/22 , C07D251/16
Abstract: PCT No. PCT/EP94/03331 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Oct. 10, 1994 PCT Pub. No. WO95/11237 PCT Pub. Date Apr. 27, 1995A process for preparing asymmetrically substituted triazines of the formula I I where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II II with a carboxylic acid derivative in the presence of an alcohol of the formula III R2-OHIII,which comprises reacting a carboxylic acid ester of the formula IV R3-COOR4IV,where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
-
公开(公告)号:AU7812694A
公开(公告)日:1995-05-08
申请号:AU7812694
申请日:1994-10-10
Applicant: BASF AG
Inventor: SCHAFER BERND , MAYER HORST
IPC: C07D251/46 , B01J27/122 , B01J27/138 , B01J31/04 , B01J31/22 , C07D251/16
Abstract: PCT No. PCT/EP94/03331 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Oct. 10, 1994 PCT Pub. No. WO95/11237 PCT Pub. Date Apr. 27, 1995A process for preparing asymmetrically substituted triazines of the formula I I where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II II with a carboxylic acid derivative in the presence of an alcohol of the formula III R2-OHIII,which comprises reacting a carboxylic acid ester of the formula IV R3-COOR4IV,where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.
-
公开(公告)号:CA2380169C
公开(公告)日:2007-01-09
申请号:CA2380169
申请日:2000-07-11
Applicant: BASF AG
Inventor: SCHAFER BERND , KOSER STEFAN , KNOPP MONIKA
IPC: C07D277/20 , C07D277/56
Abstract: The present invention relates to a method for producing 2-amino-methyl-4-cya no- thiazol, including a step in which an aminonitrile is stirred with a cystein ester.
-
公开(公告)号:CA2174332C
公开(公告)日:2006-02-07
申请号:CA2174332
申请日:1994-10-10
Applicant: BASF AG
Inventor: SCHAFER BERND , MAYER HORST
IPC: C07D251/16
Abstract: Described is a method of preparing unsymmetrically substituted triazines of formula (I), in which R1 is hydrogen, methyl or ethyl, R2 and R3, independently of each other, are an optionally substituted hydrocarbon group , by reacting a cyanoguanidine of formula (II) with a carboxylic acid derivati ve in the presence of an alcohol of formula (III), the method being characteriz ed in that the reaction is carried out with a carboxylic acid ester of formula (IV), in which R3 is as defined above and R4 is an optionally substituted hydrocarbon group, in the presence of a base or a carboxylic acid amide selected from the group comprising N,N-dialkylformamide, N,N-dialkylacetamid e and N-methylpyrrolidone and in the presence of a salt or a salt-like compoun d of one of the elements magnesium, calcium, aluminium, zinc, copper, iron, cobalt, nickel and chromium.
-
公开(公告)号:SK16172001A3
公开(公告)日:2002-06-04
申请号:SK16172001
申请日:2000-05-03
Applicant: BASF AG
Inventor: SCHAFER BERND , HARMS GUIDO , ASCHERL HERMANN , KREI GEORG ARNOLD
IPC: C12N9/99 , A61K38/00 , A61P7/02 , A61P9/00 , A61P25/00 , A61P35/00 , C07K5/065 , C07K5/06 , C07K1/14 , A61K31/40 , A61K31/44
Abstract: The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula Iwhere n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried.
-
公开(公告)号:AU8400101A
公开(公告)日:2002-02-25
申请号:AU8400101
申请日:2001-08-09
Applicant: BASF AG
Inventor: SCHAFER BERND , GENESTE HERVE
IPC: C07C37/00 , C07C37/50 , C07C39/24 , C07C45/00 , C07C45/60 , C07C47/565 , C07C49/825 , C07C51/15 , C07C65/05 , C07D309/12 , C07F5/02 , C07F7/08
Abstract: The invention relates to a method for producing 2- and 2,5-substituted derivatives of 4-(trifluoromethyl)-phenol and 4-(2-trifluoromethyl)-phenyl)-2-tetrahydropyranyl) ether and to novel derivatives. Said method is characterised in that a compound of formula (2) 4-(trifluoromethylphenyl)-2-(tetrahydropyranyl) ether is reacted with an electrophile E-X or a combination of electrophiles E-X and E-Y in the presence of a base, X and Y having the meanings given in the description.
-
公开(公告)号:CA2380169A1
公开(公告)日:2001-02-01
申请号:CA2380169
申请日:2000-07-11
Applicant: BASF AG
Inventor: SCHAFER BERND , KOSER STEFAN , KNOPP MONIKA
IPC: C07D277/20 , C07D277/56
Abstract: The present invention relates to a method for producing 2-amino-methyl-4-cya no- thiazol, including a step in which an aminonitrile is stirred with a cystein ester.
-
20.
公开(公告)号:CO4960663A1
公开(公告)日:2000-09-25
申请号:CO98046527
申请日:1998-08-13
Applicant: BASF AG
Inventor: BLECH STEFAN , DOROTHEA STARCK , TREIBER HANS-JORG , KOSER STEFAN , SCHAFER BERND , THYES MARCO , HOGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/185 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: Sal de ácido fumárico de 2-{3-[4-(2-t-butil-6-trifluorome-tilpirimidin-4-il)piperazin-1-il]propilmercapto} pirimidin-4-ol de la fórmula y las formas tautómeras, solvatos e hidratos de la misma. Medicamento que contiene la sal de ácido fumárico o una forma tautómera, un solvato o un hidrato de la misma de acuerdo con la cláusula 1, CARACTERIZADO porque puede administrarse, en caso necesario, junto con portadores y/o sustancias auxiliares fisiológicamente aceptables. Sal de ácido fumárico o una forma tautómera, un solvato o hidrato de la misma de acuerdo con la claúsula 1 utilizada para preparar un medicamento para el tratamiento de enfermedades que responden a la acción de ligandos de dopamina D3 .
-
-
-
-
-
-
-
-
-