公开(公告)号：DE19905837A1

公开(公告)日：2000-08-17

申请号：DE19905837

申请日：1999-02-12

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C209/00 ,  C07C209/26

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：DE19722700A1

公开(公告)日：1998-12-03

申请号：DE19722700

申请日：1997-05-30

Applicant: BASF AG

Inventor： SIMON JOACHIM ,  HENNE ANDREAS ,  LINGK HEINZ

IPC: C07C213/02 ,  C07C213/10 ,  C07C217/08 ,  B01J23/885

Abstract: Production of anhydrous 2-amino-1-methoxypropane (I) comprises (a) treating an aqueous reaction mixture (II) containing (I), obtained by reacting 1-methoxy-2-propanol with ammonia (NH3) on a catalyst, with aqueous sodium hydroxide (NaOH) solution to form an aqueous phase containing aqueous NaOH solution and a phase containing (I); (b) separating the phase (III) containing (I) from the aqueous phase; and (c) distilling (III) to separate an azeotrope of water and (I), which is recycled to step (a) or (b), and then anhydrous (I). Also claimed is a method of separating water from (II) in this way.

公开(公告)号：ES2207226T3

公开(公告)日：2004-05-16

申请号：ES99924920

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：ES2205824T3

公开(公告)日：2004-05-01

申请号：ES99923569

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG

IPC: B01J23/88 ,  B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C209/86 ,  C07C209/88 ,  C07C211/03 ,  C07C213/08 ,  C07C217/08

公开(公告)号：DE59906807D1

公开(公告)日：2003-10-02

申请号：DE59906807

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：AT248140T

公开(公告)日：2003-09-15

申请号：AT99924920

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：DE59906464D1

公开(公告)日：2003-09-04

申请号：DE59906464

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/88 ,  B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C209/86 ,  C07C209/88 ,  C07C211/03 ,  C07C213/08 ,  C07C217/08

公开(公告)号：ZA200107485B

公开(公告)日：2002-09-11

申请号：ZA200107485

申请日：2001-09-11

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C ,  C07B

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：AU4039799A

公开(公告)日：2000-08-29

申请号：AU4039799

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR ,  KRAMER ANDREAS DR ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUBLING CHRISTOPH

IPC: B01J23/88 ,  B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C209/86 ,  C07C209/88 ,  C07C211/03 ,  C07C213/08 ,  C07C217/08

公开(公告)号：DE19852282A1

公开(公告)日：2000-05-18

申请号：DE19852282

申请日：1998-11-13

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: C07C209/68 ,  C07C213/08 ,  C07C217/08 ,  C07B55/00 ,  C07C209/00

Abstract: The racemization of optically active, optionally substituted aliphatic secondary amines (I) by contacting with hydrogen and a (de)hydrogenation catalyst is carried out in the gas phase. Racemization of optically active amines (I) involves contacting (I), in the gas phase, with hydrogen and a hydrogenation or dehydrogenation catalyst at elevated temperatures. R1 = H, alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl (all optionally substituted by alkyl, cycloalkyl, alkoxy, aryloxy, alkylamino or dialkylamino); with the proviso that R1 and R2 are different. R2, R3 = alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl (all optionally substituted by alkyl, cycloalkyl, alkoxy, aryloxy, alkylamino or dialkylamino);