公开(公告)号：CA1332225C

公开(公告)日：1994-10-04

申请号：CA556832

申请日：1988-01-19

Applicant: BASF AG

Inventor： HORN DIETER ,  SPENGLER REINHARD

IPC: A61K9/14 ,  A61K9/10 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00

Abstract: An aqueous or pulverulent, water-dispersible pharmaceutical preparation which contains an emulsifier, a protective colloid and, in microdisperse form, an edible oil or fat, a sparingly watersoluble active compound being dissolved in the oil or fat, and a process for its preparation.

公开(公告)号：LT2085B

公开(公告)日：1993-07-15

申请号：LTRP532

申请日：1993-05-06

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  KLIMESCH ROGER GUENTHER ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61K9/22

公开(公告)号：FI87887B

公开(公告)日：1992-11-30

申请号：FI871539

申请日：1987-04-08

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  KLIMESCH ROGER GUENTHER ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61J3/06 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/32 ,  A61K47/00 ,  A61J3/00 ,  A61K31/47

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：NO170570B

公开(公告)日：1992-07-27

申请号：NO871513

申请日：1987-04-10

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  KLIMESCH ROGER GUENTHER ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61J3/06 ,  A61K9/20 ,  A61K47/32 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00 ,  A61K47/30

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：NO871513A

公开(公告)日：1987-10-12

申请号：NO871513

申请日：1987-04-10

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  KLIMESCH ROGER GUENTHER ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61K47/32 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00 ,  A61J

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  B29K2105/0035

公开(公告)号：NO170570C

公开(公告)日：1992-11-04

申请号：NO871513

申请日：1987-04-10

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  KLIMESCH ROGER GUENTHER ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61J3/06 ,  A61K9/20 ,  A61K47/32 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00 ,  A61K47/30

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：HUT43958A

公开(公告)日：1988-01-28

申请号：HU161787

申请日：1987-04-10

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  KLIMESCH ROGER G ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61J3/06 ,  A61K47/32 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：PT84661A

公开(公告)日：1987-05-01

申请号：PT8466187

申请日：1987-04-10

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  GUENTHER ROGER ,  LAEMMERHIRT KLAUS ,  LANG SIEGFRIED ,  SANNER AXEL ,  SPENGLER REINHARD

IPC: A61J3/06 ,  A61K47/32 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00 ,  A61K9/00

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：CA2103487C

公开(公告)日：2003-10-28

申请号：CA2103487

申请日：1993-11-19

Applicant: BASF AG

Inventor： HARTH KLAUS ,  HIBST HARTMUT ,  DEMBOWSKI JUERGEN ,  SPENGLER REINHARD ,  FLAIG ERNST

IPC: A61K9/32 ,  A61K9/22 ,  A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K47/34 ,  A61K47/24 ,  A61K9/24

Abstract: of the disclosure: A novel delayed-release form for pharmaceutical active compounds, characterized by a core containing the active compound and a diffusion- inhibiting, adhesive coating layer having a thickness in the range from 0.01 to 10 .mu.m, consisting of a chemical network which has been applied to the support in a plasma-assisted chemical deposition process, and a process for its production are described.

公开(公告)号：DE19839276A1

公开(公告)日：2000-03-02

申请号：DE19839276

申请日：1998-08-28

Applicant: BASF AG

Inventor： SPENGLER REINHARD ,  ROSENBERG JOERG

IPC: A61J3/06 ,  A61K9/20 ,  A61K9/28 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24

Abstract: The invention relates to a method for producing solid dosing forms by forming a plastic mixture comprised of at least one polymeric bonding agent, at least one active substance, and of optional common additives, and by shaping the plastic mixture into the solid dosing forms using a form tool. During shaping, an agent with modified surface properties is deposited on the surface of the plastic mixture in a finely dispersed manner. Said agent with modified surface properties is preferably a surfactant, a lipophilic compound, an antioxidant, a colorant or an agent with an antistatic action and/or lubricating action.