公开(公告)号：WO9944588A3

公开(公告)日：1999-10-28

申请号：PCT/EP9901271

申请日：1999-02-26

Applicant: BASF AG ,  KLEINKE ANDREAS ,  KESSLER THOMAS ,  ROSENBERG JOERG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JOERG

Inventor： KLEINKE ANDREAS ,  KESSLER THOMAS ,  ROSENBERG JOERG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/192

CPC classification number: A61K31/192 ,  A61K9/1623 ,  A61K9/1694 ,  A61K31/135

Abstract: The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.

Abstract translation: 一种用于制备包含至少实心球形成型体的过程中的赋形剂基质均匀地分散在一种药物活性成分，通过将成分混合到熔融和随后的成形，其特征在于，至少一种活性药物成分与至少一种热塑性加工的矩阵佐剂均匀熔体 用粘度加工小于5000毫帕·秒，和成形用旋转穿孔辊的帮助下到其随后通过冷却固化滴熔体中。

公开(公告)号：WO9707786A3

公开(公告)日：1997-04-03

申请号：PCT/EP9603667

申请日：1996-08-21

Applicant: BASF AG ,  ROSENBERG JOERG ,  BREITENBACH JOERG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/20

CPC classification number: A61K9/2054 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2095

Abstract: Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process.

公开(公告)号：WO9810752A3

公开(公告)日：1998-06-18

申请号：PCT/EP9704984

申请日：1997-09-11

Applicant: BASF AG ,  BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

Inventor： BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

Abstract: The present invention relates to a process for producing solid dosage forms by mixing at least one polymer binder, possibly at least one active substance and possibly the usual additives, as well as products derived from this mixture, of which at least one component is added in liquid state. 00000

Abstract translation: 00000

公开(公告)号：WO9715293A3

公开(公告)日：1997-08-14

申请号：PCT/EP9604601

申请日：1996-10-23

Applicant: BASF AG ,  BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.

公开(公告)号：WO0191727A3

公开(公告)日：2002-05-10

申请号：PCT/EP0106116

申请日：2001-05-29

Applicant: BASF AG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

CPC classification number: A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  B29C47/0011 ,  B29C47/8895

Abstract: The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.

Abstract translation: 本发明涉及基于一种药物成分和与脂质成分和粘合剂成分，以及使用该制剂的如在生命科学领域的剂型的制剂底座上自乳化制剂。 本发明还描述了通过混合制剂组分以形成一个塑料混合物制备的自乳化制剂的方法，和任选的嵌合时的制剂的作为剂型，有利地使用熔融挤出。 在水或含水液体，所述制剂自发形成乳液。

公开(公告)号：WO0057854A3

公开(公告)日：2001-03-15

申请号：PCT/EP0002381

申请日：2000-03-17

Applicant: BASF AG ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  LIEPOLD BERND ,  BREITENBACH JOERG

Inventor： ROSENBERG JOERG ,  BERNDL GUNTHER ,  LIEPOLD BERND ,  BREITENBACH JOERG

IPC: A61K47/10 ,  A61K9/16 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

CPC classification number: A61K9/1617 ,  A61K9/1635 ,  A61K9/1694

Abstract: The invention relates to mechanically stable pharmaceutical presentation forms for peroral administration which in addition to one or more active ingredients and at least one thermoplastically mouldable matrix-forming auxiliary contain more than 10 and up to 40 % by weight of a surface-active substance which has an HLB of between 2 and 18 and is liquid at 20 DEG C or has a dropping point at between 20 and 50 DEG C.

Abstract translation: 使用涉及机械稳定的药物剂型经口给药，包括，除了一种或多种活性成分和至少一种可熔融加工的基质形成赋形剂大于10和高达40重量具有2至18的HLB值的表面活性剂的％，其中 20℃下是液体或在20〜50℃的滴点

公开(公告)号：WO9726866A3

公开(公告)日：1997-09-18

申请号：PCT/EP9700185

申请日：1997-01-17

Applicant: BASF AG ,  BREITENBACH JOERG ,  ROSENBERG JOERG

Inventor： BREITENBACH JOERG ,  ROSENBERG JOERG

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

CPC classification number: A61K31/192 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2095

Abstract: The invention concerns preparation of non-steroidal analgesics with antipyretic and antiphlogistic effect, obtained through extrusion and moulding of a melt containing in addition one or more substances in a mixture of: a) 40 to 99.5 wt% of a homopolymer of N -vinylpyrrolidone with a K value according to Fikentscher of 30; b) 0.25 to 59.75 wt% of a water-soluble copolymer of N-vinylpyrr olidone; and c) 0.25 to 10 wt% of one or more physiologically ac ceptable sodium or potassium salts, where the quantities refer to the total of the components a), b) and c). 00000

Abstract translation: 00000

公开(公告)号：AT344019T

公开(公告)日：2006-11-15

申请号：AT01957809

申请日：2001-05-29

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.

公开(公告)号：CA2265532C

公开(公告)日：2006-04-04

申请号：CA2265532

申请日：1997-09-11

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  ROSENBERG JOERG ,  KLEINKE ANDREAS ,  BREITENBACH JORG

IPC: A61J3/00 ,  A61K9/20 ,  A61K9/16 ,  A61K9/22 ,  A61K47/30

Abstract: The present invention relates to a process for producing solid dosage forms by mixing at least one polymer binder, possibly at least one active substance and possibly the usual additives, as well as products derived from this mixture, of which at least one component is added in liquid state.

公开(公告)号：CA2213719C

公开(公告)日：2005-01-11

申请号：CA2213719

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30 ,  A61K31/40

Abstract: Transparent rapid-release active agent preparations obtainable by the extrusion of melts containing non-steroid analgesics, homopolymers of N-vinyl pyrrolidone, saccharides or sugar alcohols and sodiu m or potassium salts.