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    METHOD FOR THE PRODUCTION OF (S)-3-METHYLAMINO-1-(THIEN-2-YL)PROPAN-1-OL
    13.
    发明专利
    METHOD FOR THE PRODUCTION OF (S)-3-METHYLAMINO-1-(THIEN-2-YL)PROPAN-1-OL 未知

    公开(公告)号：CA2493451C

    公开(公告)日：2011-02-22

    申请号：CA2493451

    申请日：2003-07-31

    Applicant: BASF AG

    Inventor： STUERMER RAINER

    IPC: C07D333/20 ,  C07B57/00

    Abstract: The invention relates to a method for the production of enantiomer-pure (S)-3-methylamino-1-(thien-2-yl)propan-1-ol of formula (II-S) by obtaining (S)-3-hydroxy-3-thien-2-ylproipionitril from its enantiomer mixture with the R-isomer and by subsequently reacting (S)-3-hydroxy-3-thien-2-ylpropionitril with hydrogen and methylamine in the presence of a catalyst in order to obtain (II-S).

    15.
    发明专利
    未知

    公开(公告)号：AT378326T

    公开(公告)日：2007-11-15

    申请号：AT04702333

    申请日：2004-01-15

    Applicant: BASF AG

    Inventor： STUERMER RAINER

    IPC: C07D333/22 ,  C07D333/16

    Abstract: 3-methylamino-1-(2-thienyl)-1-propanone (I) and its acid addition salts are new. An Independent claim is also included for preparation of (+)-(S)-N- methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate (II; Duloxetin (RTM)), using (I) or its salt as intermediate.

    New bacterial lipase mutants, useful for enantioselective conversion, e.g. acylation of alcohols, have increased specific activity
    17.
    发明专利
    New bacterial lipase mutants, useful for enantioselective conversion, e.g. acylation of alcohols, have increased specific activity 未知

    公开(公告)号：DE10205444A1

    公开(公告)日：2003-08-21

    申请号：DE10205444

    申请日：2002-02-08

    Applicant: BASF AG

    Inventor： MATUSCHEK MARKUS ,  STUERMER RAINER ,  HAUER BERNHARD ,  KLEBE GERHARD ,  BARCOLA MARCO

    IPC: C07K14/21 ,  C12N1/21 ,  C12N9/20 ,  C12N15/55

    Abstract: Lipase variants (I) prepared by performing at least one amino acid substitution in a starting lipase (II), of lipase homology families I.1 or I.2 are new. The amino acid substitution is at a position corresponding to positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286 or 289 of a 319 residue prototype lipase sequence (S1), given in the specification. Independent claims are also included for the following: (1) nucleic acid (II) that encodes (I); (2) nucleic acid constructs that contain (II); (3) host organisms transformed with the constructs of (2); (4) preparing (I) by culturing the organisms of (3); (5) lipase formulations containing at least one (I); (6) enzyme-catalyzed or enantioselective conversion of substrates using (I); and (7) preparing optically active compounds by enantioselective reaction of a stereoisomeric mixture or racemate of a lipase-sensitive substrate, using (I), then separation of the reaction mixture.

    New bacterial lipase mutants, useful for enantioselective conversion, e.g. acylation of alcohols, have increased specific activity
    18.
    发明专利
    New bacterial lipase mutants, useful for enantioselective conversion, e.g. acylation of alcohols, have increased specific activity 未知

    公开(公告)号：DE10151292A1

    公开(公告)日：2003-04-30

    申请号：DE10151292

    申请日：2001-10-22

    Applicant: BASF AG

    Inventor： MATUSCHEK MARKUS ,  STUERMER RAINER ,  HAUER BERNHARD ,  KLEBE GERHARD ,  BOCOLA MARCO

    IPC: C12N9/20 ,  C12N15/55 ,  C07K14/21

    Abstract: Lipase variants (I) prepared by performing at least one amino acid substitution in a starting lipase (II), of lipase homology families I.1 or I.2 are new. The amino acid substitution is at a position corresponding to positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286 or 289 of a 319 residue prototype lipase sequence (S1), given in the specification. Independent claims are also included for the following: (1) nucleic acid (II) that encodes (I); (2) nucleic acid constructs that contain (II); (3) host organisms transformed with the constructs of (2); (4) preparing (I) by culturing the organisms of (3); (5) lipase formulations containing at least one (I); (6) enzyme-catalyzed or enantioselective conversion of substrates using (I); and (7) preparing optically active compounds by enantioselective reaction of a stereoisomeric mixture or racemate of a lipase-sensitive substrate, using (I), then separation of the reaction mixture.

    Production of enzyme-containing polymers useful as biocatalysts with longer activity stability
    19.
    发明专利
    Production of enzyme-containing polymers useful as biocatalysts with longer activity stability 未知

    公开(公告)号：DE19832547A1

    公开(公告)日：2000-01-27

    申请号：DE19832547

    申请日：1998-07-21

    Applicant: BASF AG

    Inventor： STUERMER RAINER

    IPC: C12N9/96 ,  C08G18/32 ,  C08G18/83 ,  C12N11/02 ,  C12N11/08 ,  C12P41/00 ,  C12P1/00 ,  C12P7/62

    Abstract: The production of enzyme-containing polymers (I) comprises reacting an enzyme in an organic solvent first with a polyfunctional iso(thio)cyanate or carboxylic acid derivative and then with a polyfunctional amine. The production of enzyme-containing polymers (I) comprises reacting an enzyme in an organic solvent first with a polyfunctional iso(thio)cyanate or carboxylic acid derivative of formula (II) and then with a polyfunctional amine. R = 2- to 5-valent alkane, alkene, cycloalkane, cycloalkene, arene, aralkane, diaryl ether, diaryl thioether or diarylamine residue (cyclic residues optionally substituted by 1-4 of 1-4C alkyl, 1-4C haloalkyl and/or halogen); X = NCO or COR ; Y = NCS or COR ; s, t = 0 or more; or s+t = 2-5; R = a leaving group displaceable by an amino, hydroxy or thiol group of the enzyme; and provided that Y is COR when X is COR and vice versa. An Independent claim is also included for enzyme-containing polymers comprising structural elements of formula (III) and/or (IV). E = enzyme; X , X = O, S or NH derived from a functional group of the enzyme; Q = H or a group of formula (i); A -A = O or S; p = 0 or 1; w, q = 1-4; v = 1-100; R = R or piperazinedialkylene; R , R = H, 1-4C alkyl, aryl or alkaryl; provided that A -A are O when p is 0.

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