公开(公告)号：JP2001240525A

公开(公告)日：2001-09-04

申请号：JP2001046958

申请日：2001-02-22

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  SCHEHLMANN VOLKER ,  WUENSCH THOMAS ,  DAUSCH WILMA M

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/35 ,  A61K8/36 ,  A61K8/368 ,  A61K8/40 ,  A61K31/216 ,  A61K31/277 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To provide a light-protective agent for cosmetics/dermatology capable processing easily in oil or water, which absorbs ultraviolet rays in UV-A range at high absorbance and which is photostable and has a weak specific color. SOLUTION: A preparation for cosmetics or dermatology comprises a) 3,3- diphenylacrylic ester of formula I of 0.1-10 weight % (wherein R1 and R2 is a hydrogen atom, 1-12C alkyl group or 1-12C alkoxy group; R3 is a 3-10C cycloalkyl group which may be substituted; R4 is a hydrogen atom or CN) and b) dibenzoylmethane derivative of formula II of 0.1-10 weight % (wherein R5 to R8 is a hydrogen atom or 1-4C alkyl group; R9 and R10 is a hydrogen atom, 1-12C alkyl group or 1-12C alkoxy group).

公开(公告)号：JPH1067635A

公开(公告)日：1998-03-10

申请号：JP22346197

申请日：1997-08-20

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMUELLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/40 ,  A61K8/49 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/40 ,  C07D307/52 ,  C07D317/54 ,  C07D333/24 ,  A61K7/42 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a cosmetic preparation for protecting human skins from solar light by using a partially specific new compound as a UV light filter singly or together with a known light-absorbing compound in a UV light region. SOLUTION: This α-acyl, β-allylacylnitrile of formula I (R to R are each H, a 18C aliphatic or alicyclic group, or two of R to R together form a five or six-membered ring; R , R are each an aromatic or heteroaromatic group having 5-12 atoms in the ring; R may be H) is used as a UV-A filter. A compound of formula II [R to R are each a low mol.wt. alkyl; R is 2-thienyl, 4-(3,5-di-t-butyl)-1-hydroxy, an alkoxyphenyl] among the compounds of formula I is new. The contact of the compound of formula I in a cosmetic preparation is approximately 10-90 pts.wt. based on the whole amount of the UV-B and UV-A absorbing substances. The UV-B filter substance is e.g. 4-aminobenzoic acid, etc.

公开(公告)号：ES2228322T3

公开(公告)日：2005-04-16

申请号：ES00105806

申请日：2000-03-18

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  BACH THORSTEN ,  SPIEGEL ANJA

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/196 ,  A61K31/24 ,  A61K31/40 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C225/00 ,  C07C225/22 ,  C07C229/52 ,  C07D295/10 ,  C07D295/112 ,  C09K3/00 ,  A61K7/42

Abstract: Empleo de hidroxibenzofenonas aminosubstituidas de la fórmula general Ib, en la que los substituyentes tienen, independientemente entre sí, el siguiente significado: R1 y R2 significan hidrógeno, alquilo con 1 a 12 átomos de carbono, pudiendo formar los substituyentes R1 y R2 junto con el átomo de nitrógeno, con el que están enlazados, un anillo con 5 o 6 miembros; R5 significa hidrógeno, alquilo con 1 a 12 átomos de carbono, cicloalquilo con 3 a 6 átomos de carbono, como filtros de los UV-A, fotoestables, en preparaciones cosméticas y farmacéuticas para la protección de la piel humana o del cabello humano frente a las irradiaciones solares, solos o junto con compuestos que absorben en el intervalo UV, en sí conocidos, para preparaciones cosméticas y farmacéuticas.

公开(公告)号：ES2186829T3

公开(公告)日：2003-05-16

申请号：ES97113930

申请日：1997-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMUELLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/40 ,  A61K8/49 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/40 ,  C07D307/52 ,  C07D317/54 ,  C07D333/24 ,  A61K7/42

Abstract: The use of compounds of formula (I) as UV-A filters in cosmetic products (optionally in combination with standard UV absorbers) to protect the human skin against sunlight is claimed. R1-R3 = H or (cyclo)aliphatic group containing up to 18 C, or two of these groups can combine to form a 5 or 6-membered ring ; R4 = optionally substituted (hetero)aryl containing 5-12 ring atoms ; and R5 = R4 or H. Also claimed are (i) cosmetic products containing (I) for protecting the epidermis layer against UV radiation with a wavelength of 280-400 nm and (ii) compounds of formula (II) : R7-R9 = lower alkyl ; R6 = 2-thienyl (optionally substituted with lower alkyl), 4-(3,5-di-t-butyl)-1-hydroxyphenyl or 4-(3,5-di-t-butyl)-1-alkoxyphenyl.

公开(公告)号：DE10143963A1

公开(公告)日：2003-03-27

申请号：DE10143963

申请日：2001-09-07

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  WUENSCH THOMAS ,  ANDRE VALERIE

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/06 ,  A61K8/33 ,  A61K8/34 ,  A61K8/37 ,  A61K8/41 ,  A61K8/44 ,  A61K8/58 ,  A61K8/72 ,  A61K8/89 ,  A61K8/891 ,  A61K8/894 ,  A61Q15/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/42

Abstract: Cosmetic and dermatological compositions in the form of W/O emulsions contain hexyl 2-(4-diethylamino-2-hydroxybenzoyl) benzoate.

公开(公告)号：DE10009442A1

公开(公告)日：2001-08-30

申请号：DE10009442

申请日：2000-02-29

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  SCHEHLMANN VOLKER ,  WUENSCH THOMAS ,  DAUSCH WILMA M

IPC: A61K8/35 ,  A61K8/40 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42 ,  C07C49/784 ,  C07C49/84 ,  C07C69/54 ,  C07C255/23

Abstract: Cosmetic or dermatological compositions comprising 0.1-10 wt.% of a cycloalkyl 3,3-diphenylacrylate (I) and 0.1-10 wt.% of a dibenzoylmethane derivative (II) are new. Cosmetic or dermatological compositions comprising 0.1-10 wt.% of a cycloalkyl 3,3-diphenylacrylate of formula (I) and 0.1-10 wt.% of a dibenzoylmethane derivative of formula (II) are new: [Image] R1>, R2>H, 1-12C alkyl or 1-12C alkoxy; R3>optionally substituted 3-10C cycloalkyl; R4>H or CN; R5>-R8>H or 1-4C alkyl; R9>, R1>0>H, 1-12C alkyl or 1-12C alkoxy.

公开(公告)号：DE19940889A1

公开(公告)日：2001-03-01

申请号：DE19940889

申请日：1999-08-27

Applicant: BASF AG

Inventor： WUENSCH THOMAS ,  WESTENFELDER HORST

IPC: A61K8/27 ,  A61K8/49 ,  A61Q17/04 ,  A61K7/40

Abstract: A cosmetic or pharmaceutical composition comprises at least one 1,3,5-triazine derivatives (I) (0.1-10 wt. %) and zinc oxide (0.1-15 wt. %). A cosmetic or pharmaceutical composition comprises at least one 1,3,5-triazine derivatives of formula (I) (0.1-10 wt. %) and zinc oxide (0.1-15 wt. %). R -R = 1-20C alkyl, aryl or heteroaryl (all optionally substituted); X = O or NR ; and R = 1-20C alkyl, aryl, heteroaryl (all optionally substituted) or H.

公开(公告)号：DE19926779A1

公开(公告)日：2000-12-14

申请号：DE19926779

申请日：1999-06-11

Applicant: BASF AG

Inventor： PRECHTL FRANZ ,  HABECK THORSTEN ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  C07D311/58 ,  A61K8/30 ,  A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/40 ,  A61K8/49 ,  A61K47/08 ,  A61K47/14 ,  A61K47/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/34 ,  C07C261/02 ,  C07D311/04 ,  C07D495/04 ,  C08K5/07 ,  C08K5/1545 ,  C08K5/20 ,  C08K5/315 ,  C08K5/3435 ,  C08K5/42 ,  C08L101/00 ,  C09K3/00 ,  C09K15/06 ,  C09K15/16 ,  C09K15/20 ,  C09K15/30 ,  A61K7/40

Abstract: 6-Vinyl-3,4-dihydro-2H-1-benzopyran, 6-vinyl-1,2,3,4-tetrahydronaphthalene or 6-vinyl-1,2,3,4-tetrahydroquinoline derivatives (I) are used as photostable ultraviolet (UV) filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation. Compounds of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation: X = O, CO, optionally substituted imino or CR9R10; Y = CO or CR9R10; R1, R2 = CN, alkanoyl, aroyl, alkoxycarbonyl, aryloxycarbonyl, optionally substituted carbamoyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl or optionally substituted sulfamoyl; R3 = H, CN, OH, COOH, CONH2, Q, OQ, CONHQ or COOQ; Q = 1-20C alkyl or 5-20C aryl; R4 = H, OH, NH2, Q or OQ; R5-R10 = H or 1-20C alkyl, or R7+R8 can be oxo. Independent claims are also included for the following: (1) use of (I) as photoprotective agents for stabilizing plastics; (2) cosmetic compositions for protecting human epidermis and hair against UV light of wavelength 280-400 nm, comprising (I) in a carrier; and (3) new compounds of formula (II): R3' = lower alkyl; R4' = H, lower alkyl or lower alkoxy; X' = O or CRR; R = H or lower alkyl.

公开(公告)号：DE19917906A1

公开(公告)日：2000-10-26

申请号：DE19917906

申请日：1999-04-20

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  BACH THORSTEN ,  SPIEGEL ANJA

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/196 ,  A61K31/24 ,  A61K31/40 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C225/00 ,  C07C225/22 ,  C07C229/52 ,  C07D295/10 ,  C07D295/112 ,  C09K3/00 ,  A61K7/42

Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.

公开(公告)号：AU2886900A

公开(公告)日：2000-10-26

申请号：AU2886900

申请日：2000-04-18

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  BACH THORSTEN ,  SPIEGEL ANJA

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/196 ,  A61K31/24 ,  A61K31/40 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C225/00 ,  C07C225/22 ,  C07C229/52 ,  C07D295/10 ,  C07D295/112 ,  C09K3/00 ,  A61K7/44 ,  A61P43/00

Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.