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公开(公告)号：AU699405B2
公开(公告)日：1998-12-03
申请号：AU2912895
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN LEE , BRAUKER JAMES H , JOHNSTON WILLIAM D , LEVON STEVEN A , MARYANOV DAVID A
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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公开(公告)号：CA2101339A1
公开(公告)日：1993-06-12
申请号：CA2101339
申请日：1992-09-25
Applicant: BAXTER INT
Inventor： WOO LECON , LO YING , LING MICHAEL T K , LAURIN DEAN , GLEASON BYRON , BUAN LILLIAN A , JOHNSTON WILLIAM D
IPC: A61J1/10 , B29C65/00 , B29C65/04 , B29C65/52 , B29L9/00 , B29L22/00 , B32B7/02 , B65D65/42 , B65D75/30
Abstract: The coating of an RF active material on a non-RF active substrate material of typical thick- ness for packaging purposes, can generate suffi- cient thermal energy to effect strong bonding of the substrate materials. The RF active material may be deposited on less than the entire inner sur- face area of the substrate material, preferably, at or near the portion of the substrate surface which re- presents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing pro- cess. Flexible medical containers capable of con- taining a product which is maintained and re- moved under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.
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公开(公告)号：AT172099T
公开(公告)日：1998-10-15
申请号：AT95924737
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN LEE , BRAUKER JAMES H , JOHNSTON WILLIAM D , LEVON STEVEN A , MARYANOV DAVID A
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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公开(公告)号：MX9700148A
公开(公告)日：1998-01-31
申请号：MX9700148
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN LEE , BRAUKER JAMES H , JOHNSTON WILLIAM D , LEVON STEVEN A , MARYANOV DAVID A
Abstract: Un dispositivo implantable para la prevencion o tratamiento del cáncer, comprende una cámara implantable que contiene células de tumor, o células somáticas preparadas por ingeniería para expresar al menos un antígeno que corresponde al antígeno de un tumor del paciente, la cámara tiene una pared porosa para suministrar en uso, una frontera porosa entre las células inmunes del paciente y las células contenidas; la porosidad de la frontera siendo suficiente para permitir que el material antigénico subcelular pase a través de la frontera, mientras se evita que las células contenidas y las células inmunes del paciente pasen a través de la frontera.
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公开(公告)号：NO970054L
公开(公告)日：1997-03-10
申请号：NO970054
申请日：1997-01-07
Applicant: BAXTER INT
Inventor： GELLER ROBIN LEE , BRAUKER JAMES H , JOHNSTON WILLIAM D , LEVON STEVEN A , MARYANOV DAVID A
IPC: A61K9/00 , A61K35/12 , A61K35/13 , A61K38/00 , A61K38/19 , A61K39/00 , A61P35/00 , C12N5/08 , A61K39/385 , A61K39/39
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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Patent Agency Ranking
公开(公告)号：NO970054D0
公开(公告)日：1997-01-07
申请号：NO970054
申请日：1997-01-07
Applicant: BAXTER INT
Inventor： GELLER ROBIN LEE , BRAUKER JAMES H , JOHNSTON WILLIAM D , LEVON STEVEN A , MARYANOV DAVID A
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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公开(公告)号：CA1333165C
公开(公告)日：1994-11-22
申请号：CA528926
申请日：1987-02-04
Applicant: BAXTER INT
Inventor： MEASELLS PAUL E , JOHNSTON WILLIAM D , KWONG PETER C , LAURIN DEAN G , CZUBA LEONARD F
IPC: B32B27/16 , A61J1/00 , A61J1/05 , A61J1/10 , B32B7/02 , B32B27/08 , B32B27/22 , B65D65/40 , B65D81/20
Abstract: A sterilizable, plastic medical container has a body section formed of thin, multi layer film. The film has a first layer formed of cross-linkable plastic free or essentially free of extractable plasticizers, such as poly(ethylene vinyl acetate), and a second layer formed of a substantially non-cross-linkable plastic having a higher melting temperature than the first layer, such as high density polyethylene. The first layer is inwardly oriented in contact with the contents of the container. A port formed of the same plastic can be heat sealed to the body section. The container is irradiated to effect cross-linking, filled with fluid, and the port sealed. The fluid filled container can then be heat or steam sterilized.
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公开(公告)号：DE3782745T2
公开(公告)日：1993-04-01
申请号：DE3782745
申请日：1987-02-05
Applicant: BAXTER INT
Inventor： MEASELLS PAUL E , LAURIN DEAN G , JOHNSTON WILLIAM D , CZUBA LEONARD F , KWONG PETER C
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公开(公告)号：DK0676935T3
公开(公告)日：2001-12-27
申请号：DK93908495
申请日：1993-03-25
Applicant: BAXTER INT
Inventor： JOHNSON ROBERT C , BRAUKER JAMES H , HILL RONALD S , MARTINSON LAURA A , JOHNSTON WILLIAM D
Abstract: Implant assemblies (10) and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary between the host and the implanted cells (12). The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells (12) during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells (12) to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.
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公开(公告)号：GR3022723T3
公开(公告)日：1997-06-30
申请号：GR970400413
申请日：1997-03-03
Applicant: BAXTER INT
Inventor： WOO LECON , LO YING , LING MICHAEL R K , LAURIN DEAN , GLEASON BYRON , BUAN LILLIAN A , JOHNSTON WILLIAM D
IPC: A61J1/10 , B29C65/00 , B29C65/04 , B29C65/52 , B29L9/00 , B29L22/00 , B32B7/02 , B65D65/42 , B65D75/30 , B29L , A61M1/14
Abstract: The coating of a RF active material on a non-RF active substrate material of typical thickness for packaging purposes, can generate sufficient thermal energy to effect strong bonding of the substrate materials. The RF active material may be-deposited on less than the entire inner surface area of the substrate material, preferably, at or near the portion of the substrate surface which represents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing process. Flexible medical containers capable of containing a product which is maintained and removed under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.
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