公开(公告)号：EP1015089A4

公开(公告)日：2000-12-20

申请号：EP98930444

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  MIN KYUNGYOON ,  SAHLIN MARK

IPC: G01N33/49 ,  A61B5/145 ,  A61K35/14 ,  A61M1/02 ,  A61M1/36 ,  A61P7/00 ,  B01D17/02 ,  B01D17/12 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/35

CPC classification number: B01D17/0217 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  B01D21/003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D2221/10 ,  B04B5/0442 ,  B04B13/00 ,  A61M2202/0071

Abstract: Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates a third output based, at least in part, upon the integrated output, which comprises parameters for storing the platelet volume.

公开(公告)号：EP0851784A4

公开(公告)日：1998-12-23

申请号：EP96916696

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON

IPC: A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC classification number: A61M1/0209 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/003 ,  B01D21/0087 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  A61M2202/0071

Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.

公开(公告)号：BRPI0922658A2

公开(公告)日：2016-01-05

申请号：BRPI0922658

申请日：2009-12-18

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RAUSA FRANCISCO M III ,  MIN KYUNGYOON ,  BACKES LARRY ,  POKROPINSKI SHARON ,  BAIRSTOW SHAWN F ,  RAMACHANDRAN SINDHU

IPC: A61M1/34 ,  A61M1/36

公开(公告)号：CA2382371C

公开(公告)日：2011-09-20

申请号：CA2382371

申请日：2001-07-03

Applicant: BAXTER INT

Inventor： WEST RICHARD L ,  LO YING-CHEN ,  WEBER MARK C ,  MIN KYUNGYOON ,  CORK WILLIAM H ,  ULMES JAMES J

IPC: A61B5/145 ,  G01N33/48 ,  A61B5/00 ,  A61B19/02 ,  A61M1/02 ,  A61M1/36 ,  A61M1/38 ,  A61M37/00 ,  B01D17/00 ,  B01D37/00 ,  B01D61/00 ,  B01D61/22 ,  B01L99/00 ,  C02F1/00 ,  C12M1/34 ,  G01N33/49 ,  G01N33/50 ,  G01N35/00 ,  G01N35/08 ,  G06F20060101 ,  G06F1/00

Abstract: A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.

公开(公告)号：ES2278414T3

公开(公告)日：2007-08-01

申请号：ES98934139

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  BROWN RICHARD I ,  BISCHOF DANIEL F ,  CORK WILLIAM H ,  CANTU ROBERT J

IPC: A61M1/02 ,  B04B11/04 ,  A61M1/36 ,  B01D21/26 ,  B04B5/04 ,  B04B11/02 ,  B04B13/00

Abstract: Sistema de separación sanguínea que funciona en un primer modo que sirve para hacer penetrar sangre entera en la zona de entrada (48) de una cámara (38) de tratamiento sanguíneo para separarla por centrifugación en glóbulos rojos concentrados, en plasma y en una interfaz que lleva células mononucleares, entre los glóbulos rojos concentrados y el plasma. Este sistema suprime los glóbulos rojos concentrados y el plasma desde la cámara (38), a la vez que conserva la interfaz en el interior de la cámara (38). Este sistema funciona en un segundo modo para suprimir la interfaz desde la cámara (38) introduciendo los glóbulos rojos concentrados en la zona de entrada (48). Un trayecto de salida (48) transporta la interfaz suprimida fuera de la cámara (38). Este trayecto de salida (46) comprende un primer elemento de detección (OS) que sirve para localizar las células mononucleares en la interfaz suprimida y para producir una salida detectada en el momento de la localización de las células mononucleares.

公开(公告)号：AU2002305810B2

公开(公告)日：2007-05-17

申请号：AU2002305810

申请日：2002-06-04

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON

IPC: G01N1/10 ,  A61M1/36 ,  B04B5/04 ,  C02F1/34 ,  C02F1/38 ,  C12M1/26 ,  C12M1/34 ,  C12N1/02 ,  G01N1/36

Abstract: Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).

公开(公告)号：BRPI0418262A

公开(公告)日：2007-04-27

申请号：BRPI0418262

申请日：2004-12-16

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MIN KYUNGYOON ,  AKONUR ALP

IPC: B04B5/04 ,  A61M1/36 ,  A61M1/38

Abstract: A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

公开(公告)号：BRPI0417931A

公开(公告)日：2007-04-17

申请号：BRPI0417931

申请日：2004-12-15

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  BROWN RICHARD I

IPC: A61M1/02 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  B01D21/26

Abstract: Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.

公开(公告)号：AU2002248479B2

公开(公告)日：2006-09-21

申请号：AU2002248479

申请日：2002-02-13

Applicant: BAXTER INT

Inventor： WESTBERG TOM ,  MIN KYUNGYOON ,  BROWN RICHARD I ,  ARMER ALAN ,  VISHNOI ROHIT

IPC: A61M1/02 ,  A61M1/38 ,  A61M1/34 ,  A61M1/36

Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further processes or treats the separated component.

公开(公告)号：CA2500160A1

公开(公告)日：2004-05-06

申请号：CA2500160

申请日：2003-10-21

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  MORIARITY JULIE ,  MIN KYUNGYOON

IPC: A61M1/36 ,  A61M1/38 ,  B04B5/04 ,  B04B11/06 ,  B01D43/00 ,  A61M1/00

Abstract: Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channe l along the low-G wall. The systems and methods remove the first blood compone nt through a first path that communicates with the separation channel through a n opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channe l through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.