Abstract:
Treatment apparatus, system and method are disclosed for treating a biological fluid, such as blood or blood components. The treatment may include but isnot limited to inactivation of pathogens in red cell concentrate. The system may include a disposable fluid circuit assembly and a reusable controller that controls flow through the fluid circuit for reconstituting, if necessary, a treating agent, combining the treating agent with a biological fluid and mixing the agent and biological fluid. An optional quenching agent may also be used.
Abstract:
A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
Abstract:
A blood processing centrifuge includes a disposable fluid processing assembly having a fluid processing chamber (16). Fluid is communicated to and from the fluid processing chamber (16) through a flexible umbilicus (24). The fluid processing chamber (16) spins while the centrifuge pulls the umbilicus (24) around an axis of centrifugation. The centrifuge engages the umbilicus (24) through a thrust bearing received in a gimbal assembly (78) carried on a rotating wing plate (72). The gimbal assembly (78) allows the umbilicus (24) to pivot relative to the wing plate (72) under the forces developed during centrifugation. The gimbal assembly (78) includes a bearing retainer adapted to securely retain umbilicus thrust bearings of differing sizes and a gimbal retains the bearing retainer loosely but securely.
Abstract:
A support assembly (10) for process control equipment includes a cabinet containing processing equipment (12). A vertical support pole (100) is supported on said cabinet through a collar (102) for extension and retraction. Process control equipment such as electronic control equipment (246) and a video monitor (248) is mounted in the upper end of the pole (100). At least one, and preferably two, constant force springs (120, 122) biased into fully coiled position are attached at one end to the lower end of the pole (100). The opposite end of the springs (120, 122) are mounted for free rotation on a spool (124) which is secured to the cabinet, whereby raising and lowering of the process control equipment (246, 248) is facilitated.
Abstract:
A peristaltic pumping apparatus includes a peristaltic pump rotor (298) and pump race (296). A pump tube holder (250) includes a body for supporting a flexible tubing loop (134, 136) in an erect, outwardly bowed position for placement within the pump race and for removal from the pump race. A surface juxtaposed the peristaltic pump rotor and race carries a gripping jaw assembly (270). The gripping jaw assembly opens to receive the pump tube holder body as the body is moved toward the pump rotor to place the tubing loop within the pump race. The gripping jaw assembly closes to secure the pump tube holder body on the surface in an orientation in which the tubing loop lies within the pump race for engagement with the peristaltic pump rotor.
Abstract:
A self-loading peristaltic pumping apparatus includes a pump race (296) for receiving a tubing loop, a pump rotor (298) carrying a roller (300), and a drive mechanism for rotating the rotor within the pump race. The apparatus also includes a roller locating mechanism (306) that moves the pump roller between a retracted position, free of contact with the received tubing loop (134, 136), and an extended position, at least partially within the pump race for operative contact with the received tubing loop. The apparatus includes at least one tubing guide element (304) carried by the rotor. The guide element extends from the rotor at least partially into the pump race. The guide element serves during rotation of the rotor with the roller in its retracted position, for contacting the received tubing loop (134, 136) to orient the tubing loop within the pump race.
Abstract:
Treatment apparatus, system and method are disclosed for treating a biological fluid, such as blood or blood components. The treatment may include but isnot limited to inactivation of pathogens in red cell concentrate. The system may include a disposable fluid circuit assembly and a reusable controller that controls flow through the fluid circuit for reconstituting, if necessary, a treating agent, combining the treating agent with a biological fluid and mixing the agent and biological fluid. An optional quenching agent may also be used.
Abstract:
A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
Abstract:
A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communica te with the interior for sensing a characteristic of the fluid contained therei n. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
Abstract:
A self-loading peristaltic pumping apparatus includes a pump race (296) for receiving a tubing loop, a pump rotor (298) carrying a roller (300), and a drive mechanism for rotating the rotor within the pump race. The apparatus also includes a roller locating mechanism (306) that moves the pump roller between a retracted position, free of contact with the received tubing loop (134, 136), and an extended position, at least partially within the pump race for operative contact with the received tubing loop. The apparatus includes at least one tubing guide element (304) carried by the rotor. The guide element extends from the rotor at least partially into the pump race. The guide element serves during rotation of the rotor with the roller in its retracted position, for contacting the received tubing loop (134, 136) to orient the tubing loop within the pump race.