公开(公告)号：WO1996040404A1

公开(公告)日：1996-12-19

申请号：PCT/US1996007806

申请日：1996-05-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BROWN, Richard, I. ,  PRISCO, Michael, R.

IPC: B01D21/26

CPC classification number: A61M1/0209 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  A61M2202/0071

Abstract: Blood processing systems and methods create dynamic vortex flow conditions (130) within a processing chamber (40) by conveying blood into a separation path that extends circumferentially about the rotational axis along an entry path that extends generally parallel to the rotational axis. The vortex flow conditions perfuse blood into the separation path for separation into component parts. The systems and methods confine the vortex flow pattern along the entry path by reducing the radial width of the entry path.

Abstract translation: 血液处理系统和方法通过将血液输送到沿着大致平行于旋转轴线延伸的入口路径围绕旋转轴线周向延伸的分离路径而在处理室（40）内产生动态涡流条件（130）。 涡流条件将血液灌注到分离路径中以分离成组分部分。 系统和方法通过减小进入路径的径向宽度来限制涡流图案沿入口路径。

公开(公告)号：WO1996040402A1

公开(公告)日：1996-12-19

申请号：PCT/US1996007801

申请日：1996-05-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BROWN, Richard, I. ,  FOLEY, John, T. ,  ELLIS, Dale, R.

IPC: B01D21/26

CPC classification number: A61M1/0209 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/003 ,  B01D21/0087 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  A61M2202/0071

Abstract: A chamber for rotation about a rotational axis to separate blood components includes first and second spaced apart side walls forming a separation zone. Blood conveyed into the separation zone separates into a first region of cellular components (96), a second region of plasma (98), and an interface region (58) between the first and second regions. An outlet conveys the second region of plasma from the separation zone. An interior wall (84, 86) extends into the separation zone to permit passage of the second region plasma to the outlet while retarding passage of the interface region and first of cellular components to the outlet.

Abstract translation: 用于围绕旋转轴线旋转以分离血液成分的室包括形成分离区的第一和第二间隔开的侧壁。 输送到分离区域的血液分成细胞组分（96）的第一区域，第二等离子体区域（98）和第一和第二区域之间的界面区域（58）。 出口从分离区传送等离子体的第二区域。 内壁（84,86）延伸进入分离区，以允许第二区域等离子体通向出口，同时阻止界面区域和第一蜂窝组件通过出口。

公开(公告)号：WO1996040310A1

公开(公告)日：1996-12-19

申请号：PCT/US1996007672

申请日：1996-05-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BROWN, Richard, I.

IPC: A61M01/00

CPC classification number: A61M1/385 ,  A61M1/02 ,  A61M1/0209 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0092

Abstract: Systems and methods take into account that the spleen normally holds a number of platelets in reserve out of circulation. During blood procesing, the spleen releases these platelets into the donor's circulatory system, making them available for collection. The systems and methods estimate the number of platelets NSPLEEN held in reserve by the spleen in a human body. The systems and methods derive a splenic mobilization function Spleen, which can be expressed as a function of a precount of platelets PltPRE. The systems and methods estimate NSPLEEN where: N?SPLEEN? = Spleen-1 x Plt?PRE? x DonVol where DonVol is blood volume in the body. The systems and methods can also estimate the total number of platelets NPLT in a human body, taking the Spleen function into account, where: N?PLT? = Plt?PRE? x Spleen x DonVol.

Abstract translation: 系统和方法考虑到脾脏通常保留一定数量的血小板保留在循环中。 在血液处理期间，脾脏将这些血小板释放到供体的循环系统中，使其可用于收集。 系统和方法估计在人体内由脾脏保留的血小板NSPLEEN的数量。 系统和方法得出脾脏动员功能脾，可以表达为血小板PltPRE计数的函数。 系统和方法估计NSPLEEN其中：N？SPLEEN？ =脾-1×Plt？PRE？ DonVol其中DonVol是体内血容量。 系统和方法也可以估算人体血小板NPLT的总数，考虑脾功能，其中：N？PLT？ = Plt？PRE？ x脾×DonVol。

公开(公告)号：WO1996040001A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009748

申请日：1996-06-06

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MCINTYRE, John ,  SHANNON, Donald ,  KUO, Chris ,  MCCOLLAM, Chris ,  PETERSON, Robert

IPC: A61F02/06

CPC classification number: A61F2/06 ,  Y10S623/901

Abstract: An externally supported, tape-reinforced tubular prosthetic graft and method of manufacturing therefore. The graft comprises a tubular base graft formed of expanded, sintered fluoropolymer material, a strip of reinforcement tape helically wrapped about the outer surface of the tubular base graft and attached thereto, and, an external support member helically wrapped around the outer surface of the reinforcement tape and attached thereto. The helical pitch of the reinforcement tape is different from the helical pitch of the external support member. Preferably, the helical pitch of the reinforcement tape is in a direction which is opposite the direction of the external support member.

Abstract translation: 外部支撑的带状增强管状假体移植物及其制造方法。 移植物包括由膨胀的，烧结的氟聚合物材料形成的管状基底移植物，螺旋缠绕在管状基底移植物的外表面上并附接到其上的加强带条，以及螺旋缠绕在加强件的外表面上的外部支撑构件 胶带并附着于其上。 加强带的螺距不同于外部支撑构件的螺距。 优选地，加强带的螺距在与外部支撑构件的方向相反的方向上。

公开(公告)号：WO1996039731A1

公开(公告)日：1996-12-12

申请号：PCT/US1996009076

申请日：1996-06-06

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SWENDSON, David ,  EVANS, David

IPC: H01R23/02

CPC classification number: A61B5/021 ,  H01R13/025 ,  H01R13/5219 ,  H01R13/6658 ,  H01R24/62 ,  H01R43/24 ,  H01R2201/12 ,  Y10S439/93 ,  Y10S439/948 ,  Y10T29/49149

Abstract: A female electrical connector (34) is carried on an electrical cable (26) including plural electrical conductors (28). The female connector includes an insulative housing defining a blind cavity (36) therewithin and an axial opening outwardly from the cavity. The housing carries a printed circuit board (166) carrying plural wire-like contacts (40) which individually connect with conductors of the electrical cable. The wire-like contacts (40) extend into the cavity of the connector for deflecting spring-like contact with electrical contacts carried by a male connector when the latter is inserted into the cavity of the female connector. A comb feature (50) of the female connector is formed by a strong end wall of the blind cavity and in a respective one of plural slots (52) of the comb feature movably receives a free end portion of each one of the plural wire-like contacts. The wire-like contacts (40) are free to move in the cavity in spaced apart parallel relationship between a first position against or adjacent to a shelf surface of the comb features and the second position spaced from the shelf feature as the matching male connector (20) is mated with the female connector. The end wall (138) of the female connector carries a stop member (190) preventing the male connector from being inserted into the female connector too forcefully and damaging either the wire-like contacts (40) or comb feature (50) of the female connector (34). Structural features of the female connector allow the insulative housing to be injection molded using dies which open only in the axial direction.

Abstract translation: 阴电连接器（34）承载在包括多个电导体（28）的电缆（26）上。 阴连接器包括限定其中的盲腔（36）和从空腔向外的轴向开口的绝缘壳体。 壳体承载承载多个与电缆的导体分别连接的线状触点（40）的印刷电路板（166）。 线状触点（40）延伸到连接器的空腔中，用于当插头连接器插入阴连接器的空腔中时，用于偏转与阳连接器承载的电触点的弹簧状接触。 阴连接器的梳子特征（50）由盲腔的强端壁形成，并且在梳齿特征的多个狭槽（52）的相应一个中，可移动地容纳多个线连接器中的每一个的自由端部分， 像联系人 线状触点（40）可以在空腔中以间隔开的平行关系移动，第一位置抵抗或邻近梳子特征的搁板表面，并且与搁架特征间隔开的第二位置作为匹配的公连接器（ 20）与母连接器配合。 阴连接器的端壁（138）承载止动构件（190），防止阳连接器太强插入阴连接器，并且损坏阴模的线状触点（40）或梳子特征（50） 连接器（34）。 阴连接器的结构特征允许绝缘壳体使用仅在轴向方向上打开的模具注塑。

公开(公告)号：WO1996039340A1

公开(公告)日：1996-12-12

申请号：PCT/US1996007293

申请日：1996-05-21

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DUTCHIK, Robert

IPC: B65D77/04

CPC classification number: B65D77/04 ,  A61B50/20 ,  A61B50/30 ,  A61B50/33 ,  A61B2050/0065 ,  A61L2/26 ,  A61L2202/182 ,  A61L2202/24 ,  A61M5/002 ,  A61M25/002 ,  B65D81/24

Abstract: A double-sterile package for critical-use medical apparatus includes an inner first container including an outer boundary wall impervious to microorganisms and being closed except for defining a hole. A patch of gas-permeable micro-porous sheet material is secured to the outer boundary wall spanning and closing the hole. The gas-permeable sheet material is sufficient to exclude environmental microorganisms from entering the inner first container. The first container is received into and nested within a conformal second container also having a boundary wall impervious to microorganisms and being closed except for defining a hole. This hole of the second container is also closed by a patch of the gas-permeable micro-porous sheet material, and the holes of the first and second containers are in gas-flow communication with one another. The medical apparatus within the nested containers is sterilized by evacuation of air and introduction of a sterilizing gas via the gas-permeable patches. Removal of the sterilizing gas provides a packaged sterile medical apparatus which may be transported, stored, and handled with no further need to additionally protect the sterility of the apparatus, or for further sterilization after the package is opened immediately prior to use of the apparatus.

Abstract translation: 用于关键用途医疗设备的双重无菌包装包括：内部第一容器，其包括不可微生物的外界面壁，并且除了限定孔之外是封闭的。 透气性微孔片材的贴片固定在横跨并封闭孔的外边界壁上。 透气性片材足以排除环境微生物进入内部第一容器。 第一个容器被接收入并嵌套在保形第二容器内，该容器也具有不可微生物的边界壁，并且除了限定孔之外是封闭的。 第二容器的该孔也被透气性微孔片材的贴片封闭，第一容器和第二容器的孔彼此气流连通。 嵌套容器内的医疗装置通过抽空空气和通过气体渗透性贴片引入灭菌气体进行灭菌。 去除灭菌气体提供可以运输，储存和处理的包装的无菌医疗设备，而不需要另外保护设备的无菌性，或者在使用设备之后立即打开包装后的进一步灭菌。

公开(公告)号：WO1996033753A1

公开(公告)日：1996-10-31

申请号：PCT/US1996005298

申请日：1996-04-17

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CHEN, Chi ,  EMERSON, Paul ,  KESHAVIAN, Prakash

IPC: A61M01/28

CPC classification number: A61M1/28 ,  A61M1/1609 ,  A61M1/1643

Abstract: There is disclosed a method and apparatus (10) for automatically conducting peritoneal equilibration testing. The method involves removing a sample of overnight dwell fluid from a patient in an amount sufficient to determine the concentration of a metabolite in the drain fluid. The concentration of the metabolite in the sample is then detected and the overnight dwell fluid is drained and weighed. A known weight of dialysate fluid is instilled into a patient and thereafter there are periodically withdrawn samples of the dialysate fluid and the concentration of metabolite in each sample is determined. The ratio of metabolite concentration of each of the periodically drawn samples to metabolite concentration for the overnight dwell fluid is determined. The patient is then drained after a predetermined dwell time and the volume of drained dialysate is determined. The mass trasnfer area coefficient of the patient's peritoneal membrane is then obtained as a function of the measured variables. Means (10) are provided for conducting the method for each of the steps described.

Abstract translation: 公开了一种用于自动进行腹膜平衡测试的方法和装置（10）。 该方法包括以足以确定排泄流体中的代谢物浓度的量从患者中移除过夜停留液的样品。 然后检测样品中代谢物的浓度，排出并称重过夜的停留液。 将已知体重的透析液注入患者体内，然后定期取出透析液的样品，并测定每个样品中代谢物的浓度。 确定每个周期性抽取样品的代谢物浓度与过夜停留液体的代谢物浓度之比。 然后在预定的停留时间后排出患者，并确定排出的透析液的体积。 然后获得患者腹膜的质量阻塞面积系数作为测量变量的函数。 提供了用于对所描述的每个步骤进行方法的装置（10）。

公开(公告)号：WO1996032130A1

公开(公告)日：1996-10-17

申请号：PCT/US1996004776

申请日：1996-04-08

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BURHOP, Kenneth, E. ,  COLE, Daniel, J.

IPC: A61K38/16

CPC classification number: A61K38/42

Abstract: Cross-linked hemoglobin infusion following subarachnoid hemorrhage dramatically reduces the tissue area of hypoperfusion and reduces the extent of neuronal damage in the area of hypoperfusion. A therapeutically effective dose ranges from about 1000-5500 mg of body weight and may be administered up to 72 hours after the onset of hemorrhage.

Abstract translation: 蛛网膜下腔出血后交叉血红蛋白输注显着降低灌注不足的组织面积，并减少灌注不足区域神经元损伤的程度。 治疗有效剂量范围为约1000-5500mg体重，并且可以在出血发作后至多72小时施用。

公开(公告)号：WO1996022115A1

公开(公告)日：1996-07-25

申请号：PCT/EP1996000160

申请日：1996-01-16

Applicant: BAXTER INTERNATIONAL INC. ,  DELMOTTE, Yves ,  KRACK, Geneviève

Inventor： BAXTER INTERNATIONAL INC.

IPC: A61L31/00

CPC classification number: A61L15/32 ,  A61F2310/00377 ,  A61L27/225 ,  A61L31/046

Abstract: The self-supporting sheet-like material of cross-linked fibrin has a regular pore size. It is used as a bio-mechanical barrier for the treatment of internal traumatic lesions, in particular for the prevention of adhesion formation as post-operative complication. In the course of this it can be used either alone or in combination with a fibrin glue acting as a haemostatic agent. Since the material in terms of its composition and general structure is similar to endogenous products, it has, inter alia, an excellent bio-compatibility, bio-degradability and bio-resorbability.

Abstract translation: 交联纤维蛋白的自支撑片状材料具有规则的孔径。 它用作生物机械屏障用于治疗内部创伤性损伤，特别是用于预防粘连形成作为术后并发症。 在此过程中，它可以单独使用或与用作止血剂的纤维蛋白胶组合使用。 由于材料的组成和总体结构与内源性产品相似，因此具有优异的生物相容性，生物降解性和生物可再吸收性。

公开(公告)号：WO1996019535A1

公开(公告)日：1996-06-27

申请号：PCT/US1995014210

申请日：1995-10-04

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SHANG, Shaye-wen ,  LING, Michael, Tung-Kiung ,  WOO, Lecon ,  COMETA, Christopher, C.

IPC: C08L51/00

CPC classification number: B32B27/08 ,  A61J1/10 ,  B32B1/02 ,  B32B27/302 ,  B32B27/32 ,  B32B27/34 ,  B32B2250/24 ,  B32B2270/00 ,  B32B2323/10 ,  B32B2325/00 ,  B32B2377/00 ,  B32B2439/80 ,  B32B2535/00 ,  C08L23/02 ,  C08L23/10 ,  C08L53/02 ,  C08L53/025 ,  C08L77/00 ,  C08L2205/02 ,  C08L2205/03 ,  C08L2205/035 ,  Y10T428/1334 ,  Y10T428/1345 ,  Y10T428/1352 ,  C08L2666/02

Abstract: The invention provides a flexible plastic formulation capable of being RF sealed, extruded, cast or blow-molded, gas, steam and radiation sterilized. The plastic formulation of the invention comprises: a) from about 40 to about 90 percent by weight of a polyolefin polypropylene based material; b) from about 3 to about 25 percent by weight of a functionalized block copolymer, the functionalized block copolymer consisting essentially of a central block copolymer molecule including generally equal proportions of ethylene and butylene units, and terminal blocks of polystyrene; and c) from about 3 to about 20 percent by weight a nylon. The plastic formulations of the invention are useful in the manufacture of blood bags, tubing and the like.

Abstract translation: 本发明提供一种能够被RF密封，挤出，铸造或吹塑成型的气体，蒸汽和辐射灭菌的柔性塑料制剂。 本发明的塑料制剂包括：a）约40至约90重量％的聚烯烃聚丙烯基材料; b）约3至约25重量％的官能化嵌段共聚物，所述官能化嵌段共聚物基本上由包含通常相等比例的乙烯和丁烯单元的中心嵌段共聚物分子和聚苯乙烯的端基组成; 和c）约3至约20重量％的尼龙。 本发明的塑料制剂可用于制造血袋，管等。