公开(公告)号：CA1227432A

公开(公告)日：1987-09-29

申请号：CA436747

申请日：1983-09-15

Applicant: BAXTER TRAVENOL LAB

Inventor： GRODE GERALD A

IPC: A61J1/10 ,  A01N1/02 ,  A61J1/00 ,  A61J1/05 ,  A61M1/00 ,  A61M5/00

Abstract: Methods and containers for storing platelet cells are provided. In accordance with one aspect of the invention, an improved container for storing a unit of platelet cells at an acceptable level of viability is provided wherein the container is made of polymer material and the container meets the following requirement for the gas transmission rate: 85 ? GTR ? 180; wherein GTR= wherein GTR is in units of (nanomoles)/(min.-cm Hgco2); C is a unit conversion constant of 2.68 x 10-4 in units of (nanomoles-sec.)/(cc min.); Pco2 is the CO2 gas permeability constant for the container material in units of SA is the total surface area of the container in square centimeters; and FT is the thickness of the container material in centimeters. In accordance with the invention containers and methods are provided which optimize the storage of a particular number or number range of platelet cells, so that viability and storage time are maximized.

公开(公告)号：AU1947083A

公开(公告)日：1984-04-24

申请号：AU1947083

申请日：1983-08-22

Applicant: BAXTER TRAVENOL LAB

Inventor： GRODE GERALD A

IPC: A61M5/00

公开(公告)号：CA1131562A

公开(公告)日：1982-09-14

申请号：CA345162

申请日：1980-02-06

Applicant: BAXTER TRAVENOL LAB

Inventor： GEISSLER ULRICH C ,  GRODE GERALD A ,  STITH WILLIAM J ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M5/14 ,  C08K5/12

Abstract: A method is disclosed for storing blood for a period of days ln a container made of a blood-compatible polymer comprising a sterilizable, chlorine-free plastic material. The method comprises providing to said blood in said container a sufficient concentration of a dispersed dialkylphthalate in which said alkyl groups each contain 4 to 12 carbon atoms, to cause a reduced plasma hemoglobulin content of blood stored in contact therewith for 21 days, when compared with blood stored in contact with the same blood-compatible material free of said antihemolytic agent.

公开(公告)号：CA1092550A

公开(公告)日：1980-12-30

申请号：CA264724

申请日：1976-11-02

Applicant: BAXTER TRAVENOL LAB

Inventor： GRODE GERALD A ,  BOGGS DANIEL R ,  WRIGHT JAMES I

IPC: A61J1/00 ,  A61J1/14 ,  B29C65/00 ,  B29C65/04 ,  A61M5/14

Abstract: FLEXIBLE COLLAPSIBLE BLOOD FREEZING CONTAINERS Inventors: Gerald A. Grode Daniel R. Boggs James I. Wright Improved, flexible, collapsible containers are provided for the storage of frozen blood and the like at cryogenic temperatures. The containers are defined by plastic walls consisting essentially of a biaxiallyoriented ethylene-vinyl acetate copolymer containing from ten to thirty-five percent by weight of vinyl acetate units. The container wall thickness is typically from 0.01 to 0.025 inch.

公开(公告)号：NO793417A

公开(公告)日：1980-04-29

申请号：NO793417

申请日：1979-10-25

Applicant: BAXTER TRAVENOL LAB

Inventor： COLLINS HENRY W ,  MEASELLS PAUL E ,  GAJEWSKI HENRY M ,  MIRIPOL JEFFREY E ,  GEISSLER ULRICH C ,  STITH WILLIAM J ,  GRODE GERALD A ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12 ,  A61M

CPC classification number: A61J1/10 ,  A61L33/0005 ,  A61L33/0052 ,  A61M1/3687 ,  C08K5/12 ,  Y10S128/24 ,  C08L67/02

公开(公告)号：IT1166913B

公开(公告)日：1987-05-06

申请号：IT2678879

申请日：1979-10-25

Applicant: BAXTER TRAVENOL LAB

Inventor： COLLINS W HENRY ,  GAJEWSKI HENRY M ,  GEISSLER ULRICH C ,  GRODE GERALD A ,  MEASELLS PAUL E ,  MIRIPOL JEFFREY E ,  STITH J WILLIAM ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12 ,  C08L

Abstract: Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

公开(公告)号：IT1129697B

公开(公告)日：1986-06-11

申请号：IT1960080

申请日：1980-01-31

Applicant: BAXTER TRAVENOL LAB

Inventor： BUCKLES RICHARD G ,  GARBER JAN W ,  GEISSLER ULRICH C ,  GRODE GERALD A ,  STITH WILLIAM J ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M5/14 ,  C08K5/12 ,  A61B

Abstract: Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable ester such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

公开(公告)号：FR2471928A1

公开(公告)日：1981-06-26

申请号：FR8006333

申请日：1980-03-21

Applicant: BAXTER TRAVENOL LAB

Inventor： BUCKLES RICHARD G ,  GARBER JAN W ,  GEISSLER ULRICH C ,  GRODE GERALD A ,  STITH WILLIAM J ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M5/14 ,  C08K5/12 ,  B65D81/24 ,  A61M1/00

Abstract: Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable ester such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

公开(公告)号：IT8119453D0

公开(公告)日：1981-02-02

申请号：IT1945381

申请日：1981-02-02

Applicant: BAXTER TRAVENOL LAB

Inventor： GRODE GERALD A ,  MIRIPOL JEFFREY E

IPC: A01N1/02 ,  A61K35/14 ,  A61K

Abstract: An aqueous red cell storage solution for packed cells which permits removal of essentially all plasma from a unit of blood, followed by reconstitution of the packed cells of the unit in preferably about 80 to 150 ml. of solution for improved cell viability on long term storage. The red cell storage solution contains adenine, glucose or fructose, sodium chloride, and mannitol.

公开(公告)号：AU5210079A

公开(公告)日：1980-05-01

申请号：AU5210079

申请日：1979-10-24

Applicant: BAXTER TRAVENOL LAB

Inventor： COLLINS HENRY W ,  GAJEWSKI HENRY M ,  GEISSLER ULRICH C ,  GRODE GERALD A ,  MEASELLS PAUL E ,  MIRIPOL JEFFREY E ,  STITH WILLIAM J ,  WILLIAMS RONALD A

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61K35/14 ,  A61L33/00 ,  A61M1/36 ,  A61M5/14 ,  C08K5/12

Abstract: Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.