公开(公告)号：CA2099511C

公开(公告)日：1998-04-14

申请号：CA2099511

申请日：1993-07-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： WASKA FRANK L ,  JOHNSON WAYNE S ,  KLEIN GERALD L

IPC: G01N21/17 ,  G01N27/447

Abstract: Detecting light in a capillary electrophoresis optical system includes input and output windows in the outside surface of a capillary tube. The width of the windows is not substantially greater than the bore of the tube. A fiber optic input is spaced from the capillary tube so that the light is directed to the tube and is matched to the window width. The light output from the tube is matched to be received by a fiber optic output spaced from the capillary tube. The optical light envelop from the fiber input through the tube and to the fiber output is governed by the LaGrange Invariant. The matching is effected in accordance with the Numerical Aperture of the fiber optics.

公开(公告)号：AU665677B2

公开(公告)日：1996-01-11

申请号：AU3876993

申请日：1993-05-24

Applicant: BECKMAN INSTRUMENTS INC

Inventor： LIU CHENG-MING ,  WANG HANN-PING ,  CHEN FU-TAI ALBERT ,  STERNBERG JAMES C ,  KLEIN GERALD L

IPC: B26D5/22 ,  B26F1/02 ,  B65H20/24 ,  G01N33/577 ,  G01N33/558 ,  G01N33/561 ,  G01N33/564

Abstract: A method for perforating a sheet material provides for a perforating die located intermediate two orbital rollers. The two orbital rollers move in orbital paths in the same orbital direction at the same speed and in positions which are 180 degrees apart. Each roller acts as a temporary storage input and output in opposite phase from each other so that incoming sheet material is alternately stored and dispensed as a loop on the orbital roller. Since the rollers are out of phase, this permits a segment of the sheet material to be stopped intermediate the orbital rollers so that the perforating die can act on the stopped segment.

公开(公告)号：AU654239B2

公开(公告)日：1994-10-27

申请号：AU4168293

申请日：1993-06-30

Applicant: BECKMAN INSTRUMENTS INC

Inventor： WASKA FRANKLYN L ,  KLEIN GERALD L ,  JOHNSON WAYNE S

IPC: G01N21/17 ,  G01N27/447 ,  G01N33/48

Abstract: Detecting light in a capillary electrophoresis optical system includes input and output windows in the outside surface of a capillary tube. The width of the windows is not substantially greater than the bore of the tube. A fiber optic input is spaced from the capillary tube so that the light is directed to the tube and is matched to the window width. The light output from the tube is matched to be received by a fiber optic output spaced from the capillary tube. The optical light envelop from the fiber input through the tube and to the fiber output is governed by the LaGrange Invariant. The matching is effected in accordance with the Numerical Aperture of the fiber optics.

公开(公告)号：AU650589B2

公开(公告)日：1994-06-23

申请号：AU3707293

申请日：1993-04-21

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  KATZMANN STEVEN P

IPC: G01N27/447 ,  G09F9/37 ,  G06F15/42

Abstract: A method and apparatus for displaying capillary electrophoresis data wherein absorbance with respect to time is related to graphic values within a graphic range or scale of values and selected graphic values are displayed with respect to time. The selected graphic values may comprise a range hues, color saturation and/or brightness or may represent a monochromatic scale. The resulting representation may be horizontally aligned with the corresponding electrophoretogram absorbance values to provide both a quantitative value (electrophoretogram absorbance values) and qualitative (graphic stripe) display.

公开(公告)号：CA2094226A1

公开(公告)日：1994-01-18

申请号：CA2094226

申请日：1993-04-16

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  MILLER GARY A

IPC: G01N27/447 ,  G01N35/04 ,  G01N35/02

Abstract: An automated multi-channel capillary electrophoresis analyzer includes a plurality of capillaries having first and second ends. The first ends of the capillaries are adapted to be collectively transported to and from selected reagent reservoirs. The second ends of the capillaries are removably and sealable retained within a common manifold that is in turn in selectable fluid communication with selected reagents and a vacuum source.

公开(公告)号：CA1005256A

公开(公告)日：1977-02-15

申请号：CA199521

申请日：1974-05-10

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  MEYER RICHARD C

IPC: G01N27/26 ,  G01N27/28 ,  G01N27/447

Abstract: This invention provides an apparatus and applicator for applying liquid sample to an electrophoretic membrane. The applicator comprises two parallel strips of flexible plastic film separated by a spacer along one edge. At the other edge the strips form fingers between which are suspended liquid samples. The applicator is gripped at the laminated edge by the apparatus at the end of an arm pivotally mounted on a base plate. The arm is connected by mechanical linkage to a handle which controls movement of the arm such that the applicator can be lowered to contact a membrane supported by the base plate with the correct amount of force to deposit the liquid samples cleanly and precisely on the membrane. The gripping element of the apparatus can be adjusted to control the spacing between the fingers and thereby control the amount of sample deposited.

公开(公告)号：CA2094226C

公开(公告)日：2004-01-06

申请号：CA2094226

申请日：1993-04-16

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  MILLER GARY A

IPC: G01N27/447 ,  G01N35/04 ,  G01N35/02

Abstract: An automated multi-channel capillary electrophoresis analyzer includes a plurality of capillaries having first and second ends. The first ends of the capillaries are adapted to be collectively transported to and from selected reagent reservoirs. The second ends of the capillaries are removably and sealable retained within a common manifold that is in turn in selectable fluid communication with selected reagents and a vacuum source.

公开(公告)号：AU3696293A

公开(公告)日：1994-01-20

申请号：AU3696293

申请日：1993-04-15

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  MILLER GARY A

IPC: G01N27/447 ,  G01N35/04 ,  G01N35/02

Abstract: An automated multi-channel capillary electrophoresis analyzer includes a plurality of capillaries having first and second ends. The first ends of the capillaries are adapted to be collectively transported to and from selected reagent reservoirs. The second ends of the capillaries are removably and sealable retained within a common manifold that is in turn in selectable fluid communication with selected reagents and a vacuum source.

公开(公告)号：CA2096389A1

公开(公告)日：1994-01-18

申请号：CA2096389

申请日：1993-05-17

Applicant: BECKMAN INSTRUMENTS INC

Inventor： LIU CHENG-MING ,  WANG HANN-PING ,  STERNBERG JAMES C ,  CHEN FU-TAI A ,  KLEIN GERALD L

IPC: G01N27/447 ,  G01N33/53 ,  G01N33/561 ,  G01N33/537 ,  G01N33/577 ,  G01N33/68

Abstract: Disclosed herein are methodologies for the Capillary Electrophoretic Immunosubtraction ("CEI") of samples. In a preferred embodiment, CEI of a sample comprising constituent parts to be separated comprises tare steps of: (1) separating a first aliquot of the sample into constituent parts by capillary electrophoretic techniques, and detecting said parts; (2) admixing a second aliquot of said sample with at least one specific binding partner to a constituent of said sample, said specific binding partner capable of being substantially removed from said aliquot; (3) separating said second aliquot into constituent parts by capillary electrophoretic techniques and detecting said parts; and (4) comparing the separated constituent parts of step (3) with the separated constituent parts of step (1).

公开(公告)号：DE3115568A1

公开(公告)日：1982-04-15

申请号：DE3115568

申请日：1981-04-16

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KLEIN GERALD L ,  CAMP JUN MILLARD M ,  MEYER RICHARD C

IPC: B01F3/08 ,  B01F5/10 ,  B01F11/00 ,  B01F13/00 ,  B01L3/02 ,  B01F5/06 ,  B01J4/02

Abstract: The invention relates to an automated pipette having a mixing-T or branch line. The mixing-T branch line can be connected to a storage vessel of a diluent liquid; the diluting liquid can be combined with a sample liquid and can be mixed thoroughly therewith by alternately drawing up and expelling the liquids into the pipette and from the pipette, respectively.