公开(公告)号：CA2642495A1

公开(公告)日：2007-11-08

申请号：CA2642495

申请日：2007-01-31

Applicant: BIO RAD LABORATORIES

Inventor： CHU DANIEL Y ,  PATT PAUL J ,  CEREMONY JEFFRY M

IPC: B01L9/00 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12

公开(公告)号：CA2647424A1

公开(公告)日：2007-10-18

申请号：CA2647424

申请日：2007-04-02

Applicant: BIO RAD LABORATORIES

Inventor： PATT PAUL J ,  CHU DANIEL Y

IPC: A61N5/00

公开(公告)号：CA2608000C

公开(公告)日：2013-02-19

申请号：CA2608000

申请日：2006-05-09

Applicant: BIO RAD LABORATORIES

Inventor： PATT PAUL J ,  ARCINIEGAS GERMAN ,  CEREMONY JEFFRY

IPC: G02B21/00 ,  G02B21/06

Abstract: Nonuniformities in the efficiency of detection of individual fluorescing reaction mixtures in a well plate with a two-dimensional array well array are corrected. The nonuniformities arise both from the stimulation pattern and the detection pattern, and are corrected by adding additional segments to a pair of segmented mirrors. The additional segments are oriented to direct light to the outermost reaches (i.e., the four corners) of the array and thereby produce a stimulation pattern that has a greater intensity in the outermost regions. This compensates for a radial decline in the efficiency of the detector in detecting the emissions from the well plate, the radial decline being an artifact of systems that utilize CCDs or similar components as detectors.

公开(公告)号：CA2647424C

公开(公告)日：2013-01-15

申请号：CA2647424

申请日：2007-04-02

Applicant: BIO RAD LABORATORIES

Inventor： CHU DANIEL Y ,  PATT PAUL J

IPC: A61N5/00

Abstract: Translational motion of a scanning head relative to a planar target, or vice versa, is achieved by a belt and pulley system with a counterweight that is also driven by a belt and pulley system at the same speed but in the opposite direction as the scanning head. The components and belt and pulley system are oriented such that all moving components remain on one side of the target and remain so during their entire range of movement.

公开(公告)号：AT540307T

公开(公告)日：2012-01-15

申请号：AT06752462

申请日：2006-05-09

Applicant: BIO RAD LABORATORIES

Inventor： PATT PAUL J ,  ARCINIEGAS GERMAN ,  CEREMONY JEFFRY

IPC: G01N21/64 ,  G02B5/08

公开(公告)号：CA2622250A1

公开(公告)日：2007-05-10

申请号：CA2622250

申请日：2006-09-19

Applicant: BIO RAD LABORATORIES

Inventor： CHU DANIEL Y ,  CEREMONY JEFFRY ,  PATT PAUL J

IPC: H02K35/00 ,  H02K33/00

Abstract: A moving coil actuator that moves in a rapid back-and-forth motion is constructed with a magnet assembly that concentrates the magnetic flux in a region of limited length and with a coiled electric conductor that includes two separated regions of densely wound coil, the assembly and conductor arranged such that only one of the coil regions resides in a concentrated fl ux region at either end of the actuator stroke. This is achieved with either a single region of concentrated flux or two spatially separated regions of concentrated flux. In either case, the force constant, i.e., the motor force generated in each coil per unit of current through the coil, is non-linear, with a maximal force at each end of the stroke and a minimal force at the stroke mid-point. The result is an efficient use of the electric current and relatively small amounts of materials of construction, and accordingly less weight for the actuator to carry during its travel and its changes of direction.

公开(公告)号：AU2006247825A1

公开(公告)日：2006-11-23

申请号：AU2006247825

申请日：2006-05-09

Applicant: BIO RAD LABORATORIES

Inventor： ARCINIEGAS GERMAN ,  CEREMONY JEFFRY ,  PATT PAUL J

IPC: G02B23/00

公开(公告)号：WO2009103003A3

公开(公告)日：2009-12-30

申请号：PCT/US2009034127

申请日：2009-02-13

Applicant: BIO RAD LABORATORIES ,  PATT PAUL J

Inventor： PATT PAUL J

IPC: F21V9/16

CPC classification number: G01N21/6452 ,  B01L7/52 ,  B01L2200/025

Abstract: A fluorescence detection apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. The excitation light generator includes a diffuser to provide a more uniform light distribution. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module can interrogate different wells while in motion over the wells.

Abstract translation: 荧光检测装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 激发光发生器包括扩散器以提供更均匀的光分布。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可以在井上运动时询问不同的井。

公开(公告)号：WO2006124435A3

公开(公告)日：2008-01-03

申请号：PCT/US2006018018

申请日：2006-05-09

Applicant: BIO RAD LABORATORIES ,  PATT PAUL J ,  ARCINIEGAS GERMAN ,  CEREMONY JEFFRY

Inventor： PATT PAUL J ,  ARCINIEGAS GERMAN ,  CEREMONY JEFFRY

IPC: G01N21/64 ,  G02B5/08

CPC classification number: G02B27/0927 ,  G02B27/0977

Abstract: Nonuniformities in the efficiency of detection of individual fluorescing reaction mixtures in a well plate with a two-dimensional array well array are corrected. The nonuniformities arise both from the stimulation pattern and the detection pattern, and are corrected by adding additional segments to a pair of segmented mirrors. The additional segments are oriented to direct light to the outermost reaches (i.e., the four corners) of the array and thereby produce a stimulation pattern that has a greater intensity in the outermost regions. This compensates for a radial decline in the efficiency of the detector in detecting the emissions from the well plate, the radial decline being an artifact of systems that utilize CCDs or similar components as detectors.

Abstract translation: 校正具有二维阵列阵列的孔板中各个荧光反应混合物的检测效率的不均匀性。 不均匀性从刺激图案和检测图案都出现，并且通过将附加段添加到一对分段镜来校正。 另外的部分被定向以将光引导到阵列的最外层（即，四个角），从而产生在最外区域具有更大强度的刺激图案。 这补偿了检测器在检测井板发射时的效率的径向下降，径向下降是利用CCD或类似部件作为检测器的系统的假象。

公开(公告)号：WO2007118049A2

公开(公告)日：2007-10-18

申请号：PCT/US2007065775

申请日：2007-04-02

Applicant: BIO RAD LABORATORIES ,  CHU DANIEL Y ,  PATT PAUL J

Inventor： CHU DANIEL Y ,  PATT PAUL J

IPC: A61N5/00

CPC classification number: G01N21/253 ,  B01L7/52 ,  G01N2201/101

Abstract: Translational motion of a scanning head relative to a planar target, or vice versa, is achieved by a belt and pulley system with a counterweight that is also driven by a belt and pulley system at the same speed but in the opposite direction as the scanning head. The components and belt and pulley system are oriented such that all moving components remain on one side of the target and remain so during their entire range of movement.

Abstract translation: 扫描头相对于平面目标的平移运动，反之亦然，通过皮带和皮带轮系统来实现，该带和滑轮系统具有配重，该配重也由带和皮带轮系统以与扫描头相同的速度但与之相反的方向驱动 。 部件和皮带轮系统被定向成使得所有移动部件保持在目标的一侧并且在其整个移动范围内保持。