公开(公告)号：EP0988110A4

公开(公告)日：2003-09-17

申请号：EP98932736

申请日：1998-06-08

Applicant: CALIPER TECHN CORP

Inventor： PARCE JOHN WALLACE ,  KOPF-SILL ANNE R

IPC: B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/38 ,  G01N1/40 ,  G01N27/447

CPC classification number: B01L3/5027 ,  B01F5/0475 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01L3/502753 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2400/0418 ,  B01L2400/0421 ,  G01N1/38 ,  G01N1/40 ,  G01N27/44743 ,  G01N27/44791 ,  Y10T436/117497 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.

公开(公告)号：EP1163052A4

公开(公告)日：2002-08-14

申请号：EP00911913

申请日：2000-02-22

Applicant: CALIPER TECHN CORP

Inventor： BURD MEHTA TAMMY ,  KOPF-SILL ANNE R ,  PARCE J WALLACE ,  CHOW ANDREA W ,  BOUSSE LUC J ,  KNAPP MICHAEL R ,  NIKIFOROV THEO T ,  GALLAGHER STEVE

IPC: B01F13/00 ,  B01L3/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447 ,  G01N35/00 ,  B01J19/00

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0487 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6869 ,  C40B60/14 ,  G01N27/44756 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/143333 ,  C12Q2565/629 ,  C12Q2535/101 ,  C12Q2563/173 ,  C12Q2525/186 ,  C12Q2527/125

Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. The application particularly focusses on methods of performing a plurality of chemical reactions, for instance nucleic acid synthesis and sequencing reactions, in said microfluidic devices.

公开(公告)号：AU771068B2

公开(公告)日：2004-03-11

申请号：AU4190600

申请日：2000-04-03

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R

IPC: B01L7/00 ,  C12Q1/68 ,  C12Q1/686 ,  C12P19/34

Abstract: Methods of performing fast polymerase mediated reactions are provided. These reactions can be used in an inefficient fashion in the cycles of the polymerase mediated reactions to produce product at a much faster rate than conventional polymerase mediated reaction methods. Integrated systems for performing these methods are also provided.

公开(公告)号：AU4932001A

公开(公告)日：2001-10-08

申请号：AU4932001

申请日：2001-03-22

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  G01N27/26

Abstract: Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides a cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.

公开(公告)号：CA2373347A1

公开(公告)日：2000-11-23

申请号：CA2373347

申请日：2000-05-11

Applicant: CALIPER TECHN CORP

Inventor： WANG BENJAMIN N ,  CHOW ANDREA W ,  WADA H GARRETT ,  PARCE J WALLACE ,  ALAJOKI MARJA LIISA ,  KOPF-SILL ANNE R ,  DUBROW ROBERT S

IPC: B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/40 ,  G01N15/14 ,  G01N27/447 ,  C12Q1/00

Abstract: Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providin g substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells a nd various subcellular components are also provided. Integrated systems in whic h particles are focused and/or sorted are additionally included.

公开(公告)号：CA2372112A1

公开(公告)日：2000-10-12

申请号：CA2372112

申请日：2000-04-03

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R

IPC: B01L7/00 ,  C12Q1/68 ,  C12Q1/686 ,  C12P19/34

Abstract: Methods of performing fast polymerase mediated reactions are provided. These reactions can be used in an inefficient fashion in the cycles of the polymerase mediated reactions to produce product at a much faster rate than conventional polymerase mediated reaction methods. Integrated systems for performing these methods are also provided.

公开(公告)号：CA2510539A1

公开(公告)日：1999-03-11

申请号：CA2510539

申请日：1998-08-27

Applicant: CALIPER TECHN CORP

Inventor： PARCE J WALLACE ,  CHOW CALVIN Y H ,  KOPF-SILL ANNE R

IPC: C12M1/36 ,  C12M1/38 ,  C12M1/40 ,  C12P19/34

公开(公告)号：AU759505B2

公开(公告)日：2003-04-17

申请号：AU4017101

申请日：2001-05-01

Applicant: CALIPER TECHN CORP

Inventor： PARCE JOHN WALLACE ,  KOPF-SILL ANNE R ,  BOUSSE LUC J

IPC: B01J19/00 ,  B01L3/00 ,  C12Q1/68

公开(公告)号：AU746098B2

公开(公告)日：2002-04-18

申请号：AU9210398

申请日：1998-08-27

Applicant: CALIPER TECHN CORP

Inventor： CHOW CALVIN Y H ,  KOPF-SILL ANNE R ,  PARCE J WALLACE

IPC: G01N31/20 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N27/447 ,  G01N37/00 ,  G01N21/00 ,  C12P19/34

公开(公告)号：CA2415055A1

公开(公告)日：2002-02-14

申请号：CA2415055

申请日：2001-08-02

Applicant: CALIPER TECHN CORP

Inventor： ANDREA W CHOW ,  PARCE J WALLACE ,  KOPF-SILL ANNE R ,  DUBROW ROBERT S

IPC: B01D61/18 ,  B01L3/00 ,  B01L99/00 ,  B81B1/00 ,  B01D57/02 ,  B01L3/02 ,  G01N1/10 ,  C02F1/40

Abstract: Methods and devices for delivering fluids into microfluidic device body structures are described. The methods and devices include the use of fluid manifolds which are integrated or interchangeable with device body structures. Methods of fabricating manifolds are also provided.