公开(公告)号：WO0070353A3

公开(公告)日：2001-04-26

申请号：PCT/US0013200

申请日：2000-05-12

Applicant: CALIPER TECHN CORP ,  HODGE C NICHOLAS ,  KNAPP MICHAEL R ,  KOPF SILL ANNE R ,  NIKIFOROV THEO T ,  PARCE J WALLACE ,  CHOW CALVIN Y H

Inventor： HODGE C NICHOLAS ,  KNAPP MICHAEL R ,  KOPF-SILL ANNE R ,  NIKIFOROV THEO T ,  PARCE J WALLACE ,  CHOW CALVIN Y H

IPC: G01N33/50 ,  C07B61/00 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/25 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48 ,  C12Q1/527 ,  C40B60/14 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00 ,  G01N33/68 ,  G01N1/10

CPC classification number: C12Q1/00 ,  B01J2219/00317 ,  B01J2219/00707 ,  B01J2219/00781 ,  C40B60/14 ,  G01N33/5302 ,  G01N2333/726 ,  G01N2333/765 ,  G01N2333/795 ,  G01N2333/80 ,  G01N2333/90245 ,  G01N2333/91171 ,  G01N2333/9121 ,  G01N2333/924 ,  G01N2333/95

Abstract: Pre-screened libraries, such as pre-screened chemical composition libraries useful for drug screening, are generated using target independent assays. The methods typically involve screening of master libraries in microfluidic devices for effects that are correlated to one or more target independent parameter. Also included are multi-module workstations, such as microfluidic workstations,and integrated systems, for performing target independent assays.

Abstract translation: 预筛选的文库，例如用于药物筛选的预筛选化学组成文库，是使用目标独立测定法生成的。 所述方法通常涉及筛选微流体装置中的主文库以获得与一个或多个目标独立参数相关的效果。 还包括多模块工作站，例如微流控工作站和集成系统，用于执行目标独立测定。

公开(公告)号：WO0173417A9

公开(公告)日：2004-05-27

申请号：PCT/US0109074

申请日：2001-03-22

Applicant: CALIPER TECHN CORP ,  KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  G01N27/26

CPC classification number: G01N21/6452 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/023 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44782 ,  G01N35/0099 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6421

Abstract: Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.

Abstract translation: 分析系统和方法，其使用模块化接口结构（600）来提供样本基板（630）和分析单元（610）之间的界面，其中分析单元（610）具有用于实现各种分析和控制功能的特定接口布置 。 使用模块化接口结构（600）的每个模块的许多变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。 还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

公开(公告)号：WO0149414A2

公开(公告)日：2001-07-12

申请号：PCT/US0035658

申请日：2000-12-28

Applicant: CALIPER TECHN CORP ,  WOLK JEFFREY A ,  BIONDI SHERRI ANN ,  PARCE JOHN WALLACE ,  JENSEN MORTEN J ,  KOPF SILL ANNE R

Inventor： WOLK JEFFREY A ,  BIONDI SHERRI ANN ,  PARCE JOHN WALLACE ,  JENSEN MORTEN J ,  KOPF-SILL ANNE R

IPC: B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B40/06 ,  C40B60/14 ,  G01N1/02 ,  G01N21/64 ,  G01N35/10

CPC classification number: G01N21/6452 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00369 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01L3/02 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2300/0819 ,  B01L2300/0861 ,  B01L2400/022 ,  B01L2400/0406 ,  C12Q2565/629 ,  C40B40/06 ,  C40B60/14 ,  G01N35/10 ,  G01N2001/028 ,  G01N2035/1034 ,  G01N2035/1037 ,  G01N2035/1039 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Systems and method of sampling compounds into a microfluidic channel, comprising: providing a plurality of different compounds reversibly immobilized on a first surface of substrate; providing a capillary element having a capillary channel disposed therethrough, the capillary element having at least one open end, and a volume of solubilizing fluid present at the open end of the capillary element; moving the solubilizing fluid at the open end of the capillary element into contact with a fist compound on the surface of the substrate; sensing when the solubilizing fluid contacts the surface of the substrate, the solubilizing fluid dissolving at least a portion of the first compound; and drawing at least a portion of the dissolved first compound into the capillary element.

Abstract translation: 将化合物取样成微流体通道的系统和方法，包括：提供可逆地固定在基材的第一表面上的多种不同的化合物; 提供毛细管元件，其具有穿过其中的毛细通道，所述毛细管元件具有至少一个开口端，以及存在于毛细管元件的开口端的增溶液体积; 将毛细管元件的开口端处的增溶液移动到与基底表面上的第一化合物接触; 当增溶流体接触基底的表面时，感测溶解至少一部分第一化合物的溶解流体; 并将至少一部分溶解的第一化合物吸入毛细管元件中。

公开(公告)号：WO0021666A9

公开(公告)日：2000-08-31

申请号：PCT/US9923814

申请日：1999-10-12

Applicant: CALIPER TECHN CORP ,  CHOW ANDREA W ,  DUBROW ROBERT S ,  PARCE J WALLACE ,  SUNDBERG STEVEN A ,  WOLK JEFFREY A ,  CHIEN RING LING ,  GALLAGHER STEVEN JAMES ,  KNAPP MICHAEL R ,  KOPF SILL ANNE R ,  MEHTA TAMMY BURD

Inventor： CHOW ANDREA W ,  DUBROW ROBERT S ,  PARCE J WALLACE ,  SUNDBERG STEVEN A ,  WOLK JEFFREY A ,  CHIEN RING-LING ,  GALLAGHER STEVEN JAMES ,  KNAPP MICHAEL R ,  KOPF-SILL ANNE R ,  MEHTA TAMMY BURD

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10 ,  B01L3/02

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N2035/00237 ,  G01N2035/1062 ,  Y10S366/02 ,  Y10T436/2575

Abstract: Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

Abstract translation: 提供了用于将大量不同材料快速，有效且可重复地引入微流体分析装置的方法，设备和系统。 特别地，改进的集成移液器芯片配置，例如， 描述了能够取样非常少量需要分析的材料，将材料输送到微流体分析通道网络中，并对材料进行所需分析的吸管或电吸附器。

公开(公告)号：WO0058719A9

公开(公告)日：2001-11-15

申请号：PCT/US0007763

申请日：2000-03-23

Applicant: CALIPER TECHN CORP

Inventor： CHOW ANDREA W ,  KOPF-SILL ANNE R ,  CHOW CALVIN Y H

IPC: B01L3/00 ,  G01N27/447 ,  G01N27/26

CPC classification number: G01N27/44791 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084

Abstract: Methods and systems for designing optimized fluidic channel networks for performing different analytical operations, which include the steps of selecting a driving force, identifying at least a first reaction parameter, and designing the channel network by determining channel lengths and cross-sectional dimensions that are optimized for the reaction requirements in view of the selected driving force. Preferred methods are used to design integrated microscale fluidic systems.

Abstract translation: 用于设计用于执行不同分析操作的优化流体通道网络的方法和系统，其包括选择驱动力，识别至少第一反应参数以及通过确定经优化的通道长度和横截面尺寸来设计通道网络的步骤 鉴于所选驱动力的反应要求。 优选的方法用于设计集成微量流体系统。

公开(公告)号：WO9856956A8

公开(公告)日：1999-09-16

申请号：PCT/US9811969

申请日：1998-06-08

Applicant: CALIPER TECHN CORP ,  KOPF SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

IPC: B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N27/447 ,  G01N33/557 ,  C12Q1/70

CPC classification number: G01N33/557 ,  B01J19/0093 ,  B01J2219/0095 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/563 ,  B01L9/527 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  G01N27/447 ,  G01N27/44726 ,  G01N27/44791 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/809

Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.

Abstract translation: 提供了具有用于校正电动效果的计算机的电动装置。 还提供了通过在电动微流体装置中确定反应物和产物在反应中的速度来校正电动效应的方法。 这些微流体装置可以具有用于移动，混合和监测精确量的分析物流体的通道，凹陷和/或孔的基底。

公开(公告)号：EP1277046A4

公开(公告)日：2003-09-03

申请号：EP01922529

申请日：2001-03-22

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  G01N27/26

CPC classification number: G01N21/6452 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/023 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44782 ,  G01N35/0099 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6421

Abstract: Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.

Abstract translation: 使用模块化接口结构（600）的分析系统和方法用于提供样品基板（630）和分析单元（610）之间的接口，其中分析单元（610）具有用于实现各种分析和控制功能 。 针对模块化接口结构（600）的每个模块使用多个变型方案有利地提供了成本有效和高效的方式来使用具有特定分析和控制系统接口布置的特定基板或基板类别来执行大量测试。 还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

公开(公告)号：EP1021566A4

公开(公告)日：2002-06-19

申请号：EP98926498

申请日：1998-06-08

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

IPC: B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N27/447 ,  G01N33/557 ,  C12Q1/70

CPC classification number: G01N33/557 ,  B01J19/0093 ,  B01J2219/0095 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/563 ,  B01L9/527 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  G01N27/447 ,  G01N27/44726 ,  G01N27/44791 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/809

公开(公告)号：EP1010003A4

公开(公告)日：2002-07-10

申请号：EP97947564

申请日：1997-11-18

Applicant: CALIPER TECHN CORP

Inventor： PARCE JOHN WALLACE ,  KOPF-SILL ANNE R ,  BOUSSE LUC J

IPC: G01N27/447 ,  B01J19/00 ,  B01L3/00 ,  G01N1/10 ,  G01N1/18 ,  G01N27/26 ,  G01N27/453 ,  G01N31/00 ,  G01N37/00

CPC classification number: B01L3/50273 ,  B01L3/5025 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0688 ,  G01N27/44791 ,  Y10T436/2575

Abstract: The present invention generally provides microfluidic devices (200) and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated microscale channels (for example, 202 and 208 + 2n, where n = 0, 1, ...8) disposed within integrated body structures.

公开(公告)号：EP1035910A4

公开(公告)日：2002-07-31

申请号：EP98952119

申请日：1998-10-07

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  PARCE WALLACE J

IPC: B01J19/00 ,  B01L3/00 ,  G01N27/447 ,  B01F5/00

CPC classification number: G01N27/44791 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502776 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/084 ,  Y10S366/01 ,  Y10S366/02 ,  Y10S366/03 ,  Y10T436/2575

Abstract: The present invention is generally directed to improved microfluidic devices (100), systems, and methods of using the same. In particular, the device and systems employ channels (408, 512) having, at least in part, depths that are varied to provide advantageous effects upon the flow rate of fluids in the channel. Typically, microscale channel (408, 512) has an aspect ratio (width/depth) less than or equal to about 1. Variation of the channel depth (408, 512) may be optimized depending upon the nature of the materials to be mixed.