公开(公告)号：WO0173417A9

公开(公告)日：2004-05-27

申请号：PCT/US0109074

申请日：2001-03-22

Applicant: CALIPER TECHN CORP ,  KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  G01N27/26

CPC classification number: G01N21/6452 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/023 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44782 ,  G01N35/0099 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6421

Abstract: Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.

Abstract translation: 分析系统和方法，其使用模块化接口结构（600）来提供样本基板（630）和分析单元（610）之间的界面，其中分析单元（610）具有用于实现各种分析和控制功能的特定接口布置 。 使用模块化接口结构（600）的每个模块的许多变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。 还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

公开(公告)号：WO0186249A3

公开(公告)日：2002-03-07

申请号：PCT/US0115465

申请日：2001-05-10

Applicant: CALIPER TECHN CORP

Inventor： CHOW ANDREA W ,  BROOKS CARLTON

IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  G01N27/447 ,  F15C1/04 ,  B44C1/22 ,  G01N27/26

CPC classification number: B01L3/502715 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00891 ,  B01J2219/00961 ,  B01J2219/00966 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/502746 ,  B01L2200/06 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0415 ,  G01N27/44704 ,  G01N27/44747 ,  G01N27/44791 ,  Y10T137/2065 ,  Y10T436/25 ,  Y10T436/25625

Abstract: Methods and devices (Figure 4) for inducing high bulk hydrodynamic resistance (408) and/or inducing low electrical resistance in microscale systems (400, 412) including bulk viscosity enhancers (via 402), disinfectants, and electrolytes. High bulk hydrodynamic resistance is optionally utilized to regulate the effects of spontaneous injection and dispersion.

Abstract translation: 用于诱导高体积流体动力学阻力（408）和/或在包括体积粘度增强剂（通过402），消毒剂和电解质）的微尺度系统（400,412）中诱导低电阻的方法和装置（图4）。 任选地使用高体积流体动力学阻力来调节自发注射和分散的作用。

公开(公告)号：WO0058719A9

公开(公告)日：2001-11-15

申请号：PCT/US0007763

申请日：2000-03-23

Applicant: CALIPER TECHN CORP

Inventor： CHOW ANDREA W ,  KOPF-SILL ANNE R ,  CHOW CALVIN Y H

IPC: B01L3/00 ,  G01N27/447 ,  G01N27/26

CPC classification number: G01N27/44791 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084

Abstract: Methods and systems for designing optimized fluidic channel networks for performing different analytical operations, which include the steps of selecting a driving force, identifying at least a first reaction parameter, and designing the channel network by determining channel lengths and cross-sectional dimensions that are optimized for the reaction requirements in view of the selected driving force. Preferred methods are used to design integrated microscale fluidic systems.

Abstract translation: 用于设计用于执行不同分析操作的优化流体通道网络的方法和系统，其包括选择驱动力，识别至少第一反应参数以及通过确定经优化的通道长度和横截面尺寸来设计通道网络的步骤 鉴于所选驱动力的反应要求。 优选的方法用于设计集成微量流体系统。

公开(公告)号：WO9856956A8

公开(公告)日：1999-09-16

申请号：PCT/US9811969

申请日：1998-06-08

Applicant: CALIPER TECHN CORP ,  KOPF SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

IPC: B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N27/447 ,  G01N33/557 ,  C12Q1/70

CPC classification number: G01N33/557 ,  B01J19/0093 ,  B01J2219/0095 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/563 ,  B01L9/527 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  G01N27/447 ,  G01N27/44726 ,  G01N27/44791 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/809

Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.

Abstract translation: 提供了具有用于校正电动效果的计算机的电动装置。 还提供了通过在电动微流体装置中确定反应物和产物在反应中的速度来校正电动效应的方法。 这些微流体装置可以具有用于移动，混合和监测精确量的分析物流体的通道，凹陷和/或孔的基底。

公开(公告)号：WO0021666A9

公开(公告)日：2000-08-31

申请号：PCT/US9923814

申请日：1999-10-12

Applicant: CALIPER TECHN CORP ,  CHOW ANDREA W ,  DUBROW ROBERT S ,  PARCE J WALLACE ,  SUNDBERG STEVEN A ,  WOLK JEFFREY A ,  CHIEN RING LING ,  GALLAGHER STEVEN JAMES ,  KNAPP MICHAEL R ,  KOPF SILL ANNE R ,  MEHTA TAMMY BURD

Inventor： CHOW ANDREA W ,  DUBROW ROBERT S ,  PARCE J WALLACE ,  SUNDBERG STEVEN A ,  WOLK JEFFREY A ,  CHIEN RING-LING ,  GALLAGHER STEVEN JAMES ,  KNAPP MICHAEL R ,  KOPF-SILL ANNE R ,  MEHTA TAMMY BURD

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10 ,  B01L3/02

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N2035/00237 ,  G01N2035/1062 ,  Y10S366/02 ,  Y10T436/2575

Abstract: Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

Abstract translation: 提供了用于将大量不同材料快速，有效且可重复地引入微流体分析装置的方法，设备和系统。 特别地，改进的集成移液器芯片配置，例如， 描述了能够取样非常少量需要分析的材料，将材料输送到微流体分析通道网络中，并对材料进行所需分析的吸管或电吸附器。

公开(公告)号：EP1277046A4

公开(公告)日：2003-09-03

申请号：EP01922529

申请日：2001-03-22

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  JANN PETER C ,  JENSEN MORTEN J ,  SPAID MICHAEL ,  KENNEDY COLIN B ,  KENNEDY MICHAEL

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  G01N27/26

CPC classification number: G01N21/6452 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/023 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44782 ,  G01N35/0099 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6421

Abstract: Analytical systems and methods that use a modular interface structure (600) for providing an interface between a sample substrate (630) and an analytical unit (610) where the analytical unit (610) has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure (600) advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels (622) are also provided.

Abstract translation: 使用模块化接口结构（600）的分析系统和方法用于提供样品基板（630）和分析单元（610）之间的接口，其中分析单元（610）具有用于实现各种分析和控制功能 。 针对模块化接口结构（600）的每个模块使用多个变型方案有利地提供了成本有效和高效的方式来使用具有特定分析和控制系统接口布置的特定基板或基板类别来执行大量测试。 还提供了用于同时分析多个并行微通道（622）中的反应或条件的改进的光学照明和检测系统。

公开(公告)号：EP1272834A4

公开(公告)日：2003-06-25

申请号：EP01922248

申请日：2001-02-23

Applicant: CALIPER TECHN CORP

Inventor： CHIEN RING-LING ,  PARCE J WALLACE ,  CHOW ANDREA W ,  KOPF-SILL ANNE

IPC: G01N11/04 ,  B01L3/00 ,  B01L9/00 ,  G01N11/08 ,  G01N27/06 ,  G01N27/447 ,  G01N35/08 ,  G01N35/10 ,  G01N37/00 ,  G05D7/06 ,  G01N27/26

CPC classification number: B01L9/527 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N11/08 ,  G01N27/44791 ,  G01N2035/1044 ,  G05D7/0694 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/86131

Abstract: Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.

公开(公告)号：EP1163369A4

公开(公告)日：2002-08-28

申请号：EP00913566

申请日：2000-02-22

Applicant: CALIPER TECHN CORP

Inventor： PARCE J WALLACE ,  NIKIFOROV THEO T ,  BURD MEHTA TAMMY ,  KOPF-SILL ANNE ,  CHOW ANDREA W ,  KNAPP MICHAEL R

IPC: B01F13/00 ,  B01L3/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447 ,  G01N35/00 ,  C07H19/00 ,  C07H21/00 ,  C12P19/34

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0487 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6869 ,  C40B60/14 ,  G01N27/44756 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/143333 ,  C12Q2565/629 ,  C12Q2535/101 ,  C12Q2563/173 ,  C12Q2525/186 ,  C12Q2527/125

Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. The application particularly focusses on methods of performing a plurality of chemical reactions, for instance nucleic acid synthesis and sequencing reactions, in said microfluidic devices.

公开(公告)号：EP1021566A4

公开(公告)日：2002-06-19

申请号：EP98926498

申请日：1998-06-08

Applicant: CALIPER TECHN CORP

Inventor： KOPF-SILL ANNE R ,  CHOW ANDREA W ,  COHEN CLAUDIA B ,  SUNDBERG STEVEN A ,  PARCE JOHN WALLACE

IPC: B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N27/447 ,  G01N33/557 ,  C12Q1/70

CPC classification number: G01N33/557 ,  B01J19/0093 ,  B01J2219/0095 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/563 ,  B01L9/527 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  G01N27/447 ,  G01N27/44726 ,  G01N27/44791 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/809

公开(公告)号：EP1163052A4

公开(公告)日：2002-08-14

申请号：EP00911913

申请日：2000-02-22

Applicant: CALIPER TECHN CORP

Inventor： BURD MEHTA TAMMY ,  KOPF-SILL ANNE R ,  PARCE J WALLACE ,  CHOW ANDREA W ,  BOUSSE LUC J ,  KNAPP MICHAEL R ,  NIKIFOROV THEO T ,  GALLAGHER STEVE

IPC: B01F13/00 ,  B01L3/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447 ,  G01N35/00 ,  B01J19/00

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0487 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6869 ,  C40B60/14 ,  G01N27/44756 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/143333 ,  C12Q2565/629 ,  C12Q2535/101 ,  C12Q2563/173 ,  C12Q2525/186 ,  C12Q2527/125

Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. The application particularly focusses on methods of performing a plurality of chemical reactions, for instance nucleic acid synthesis and sequencing reactions, in said microfluidic devices.