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    METHOD AND APPARATUS FOR FIBERSCOPE
    11.
    发明专利
    METHOD AND APPARATUS FOR FIBERSCOPE 未知

    公开(公告)号：CA2578183A1

    公开(公告)日：2006-03-16

    申请号：CA2578183

    申请日：2005-08-19

    Applicant: CHEMIMAGE CORP

    Inventor： DEMUTH JOSEPH E ,  NELSON MATTHEW P ,  TUSCHEL DAVID

    IPC: G02B6/04 ,  G01J3/44 ,  G02B6/06

    Abstract: The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.

    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS
    12.
    发明专利
    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 未知

    公开(公告)号：CA2571765A1

    公开(公告)日：2006-01-12

    申请号：CA2571765

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP

    Inventor： TREADO PATRICK J ,  MAIER JOHN S ,  TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: G01J3/44 ,  G01N21/65

    Abstract: The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    METHOD AND APPARATUS FOR COUNTERFEITING PROTECTION
    13.
    发明申请
    METHOD AND APPARATUS FOR COUNTERFEITING PROTECTION 审中-公开

    公开(公告)号：WO2007078936A3

    公开(公告)日：2008-04-17

    申请号：PCT/US2006048381

    申请日：2006-12-20

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  VOIGT THOMAS C

    Inventor： TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: H04K1/00

    CPC classification number: G06K19/10

    Abstract: The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

    HYPERSPECTRAL VISIBLE ABSORPTION IMAGING OF MOLECULAR PROBES AND DYES IN BIOMATERIALS
    14.
    发明申请
    HYPERSPECTRAL VISIBLE ABSORPTION IMAGING OF MOLECULAR PROBES AND DYES IN BIOMATERIALS 审中-公开
    分子生物学中分子探针和染料的超视距可吸收成像

    公开(公告)号：WO2007038650A2

    公开(公告)日：2007-04-05

    申请号：PCT/US2006037780

    申请日：2006-09-26

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  BANGALORE ARJUN ,  KLUEVA OKSANA

    Inventor： TUSCHEL DAVID ,  BANGALORE ARJUN ,  KLUEVA OKSANA

    IPC: G01N21/00

    CPC classification number: G01N21/31

    Abstract: A system and method for obtaining hyperspectral visible absorption images. The system includes a light source which illuminates a sample containing light absorbing material, a platform, an optical lens, a detector. The platform has a section for placement of the sample and a section devoid of sample. The transmitted photons produced by the sample and collected by the optical lens are separated into a plurality of wavelength bands using a filter or a fiber array spectral translator coupled to a spectrometer. The system includes a programmable code for operating in a sample mode or background mode and calculating an absorption image. In the background mode, the platform motion is controlled so the optical lens collects transmitted photons from the portion of the platform devoid of sample to generate a background transmission image. In the sample mode, the platform motion is controlled so the optical lens collects transmitted photons from the sample to generate a sample transmission image. The sample transmission image and the background transmission image are used to generate a photon absorption image of the sample.

    Abstract translation: 一种用于获得高光谱可见吸收图像的系统和方法。 该系统包括照亮含有光吸收材料的样品的光源，平台，光学透镜，检测器。 该平台具有放置样品的部分和没有样品的部分。 由样品产生并由光学透镜收集的透射光子使用耦合到光谱仪的滤光器或光纤阵列光谱转换器分离成多个波长带。 该系统包括用于以采样模式或背景模式操作并计算吸收图像的可编程代码。 在背景模式中，控制平台运动，使得光学透镜从没有采样的平台的部分收集所发射的光子，以产生背景透射图像。 在采样模式中，控制平台运动，使得光学透镜从样本收集透射的光子以产生采样透射图像。 采样透射图像和背景透射图像用于产生样品的光子吸收图像。

    CONTROL AND MONITORING OF NON-RESONANT RADIATION-INDUCED NUCLEATION, CRYSTALLIZATION, AND POLYMORPH FORMATION
    15.
    发明申请
    CONTROL AND MONITORING OF NON-RESONANT RADIATION-INDUCED NUCLEATION, CRYSTALLIZATION, AND POLYMORPH FORMATION 审中-公开
    非共振辐射诱导的核化，结晶化和多晶形成的控制和监测

    公开(公告)号：WO2006052464A3

    公开(公告)日：2007-02-22

    申请号：PCT/US2005038694

    申请日：2005-10-26

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  BANGALORE ARJUN S

    Inventor： TUSCHEL DAVID ,  BANGALORE ARJUN S

    IPC: B01D9/00

    CPC classification number: B01D9/00 ,  B01D9/0077 ,  C07B61/00 ,  C07C45/81 ,  C07C49/255 ,  G01N21/65 ,  G01N2021/656 ,  G11B7/245

    Abstract: The invention relates to methods of assessing the polymorphic form of a substance by assessing Raman-shifted radiation scattered by a particle of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials. The invention also relates to methods of selecting and controlling polymorph formation by illuminating a material with non-resonant (i.e., non-absorbed) laser radiation as it is thermally driven through a phase transition temperature.

    Abstract translation: 本发明涉及通过评估物质颗粒散射的拉曼位移辐射来评估物质的多晶形式的方法。 该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。 本发明还涉及通过在通过相变温度热驱动的情况下照射具有非共振（即，未吸收的）激光辐射的材料来选择和控制多晶型形成的方法。

    SYSTEM AND METHOD TO PERFORM RAMAN IMAGING WITHOUT LUMINESCENCE
    17.
    发明申请
    SYSTEM AND METHOD TO PERFORM RAMAN IMAGING WITHOUT LUMINESCENCE 审中-公开
    不造成拉曼成像的系统和方法

    公开(公告)号：WO2007112099A2

    公开(公告)日：2007-10-04

    申请号：PCT/US2007007455

    申请日：2007-03-26

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  ZHANG JINGYUN

    Inventor： TUSCHEL DAVID ,  ZHANG JINGYUN

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/2803 ,  G01J3/2889 ,  G01J2003/4424 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6423

    Abstract: A system and method for collecting Raman data sets without the "contaminating" effect of luminescence emitted photons. Using a frame transfer CCD for time resolved data collection, Raman imaging may be performed without photobleaching the sample. The system may include a light source, a frame transfer CCD, an optical lens and at least one controller. The light source illuminates the sample with a plurality of photons to generate scattered photons from the sample. The frame transfer CCD has an image array and a storage array. The optical lens collects scattered photons and directs the scattered photons to the image array. The controller transfers a Raman data set representative of the scattered photons from the image array to the storage array. The frame transfer CCD may be configured so as the image array integrates the scattered photons during a Raman integration time and the controller transfers the Raman data set from the image array to storage array during a parallel transfer time. The sum of the Raman integration time and the parallel transfer time is less than the minimum time it takes to trigger luminescence from the sample.

    Abstract translation: 用于收集拉曼数据集而不发出发光光子的“污染”影响的系统和方法。 使用帧传输CCD进行时间分辨数据采集，拉曼成像可以在没有光漂白样品的情况下进行。 该系统可以包括光源，帧传送CCD，光学透镜和至少一个控制器。 光源用多个光子照射样品以从样品产生散射的光子。 帧传送CCD具有图像阵列和存储阵列。 光学透镜收集散射的光子并将散射的光子引导到图像阵列。 控制器将表示散射光子的拉曼数据集从图像阵列传送到存储阵列。 帧传送CCD可以被配置为使得图像阵列在拉曼积分时间期间对散射的光子进行积分，并且控制器在平行传送时间期间将拉曼数据集从图像阵列传送到存储阵列。 拉曼积分时间和平行传输时间的总和小于从样品触发发光所需的最小时间。

    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS
    18.
    发明申请
    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
    动物化学成像生物细胞和其他物种

    公开(公告)号：WO2006005022A3

    公开(公告)日：2006-06-15

    申请号：PCT/US2005023638

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  VOIGT THOMAS C ,  TUSCHEL DAVID

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  VOIGT THOMAS C ,  TUSCHEL DAVID

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    Abstract: The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    Abstract translation: 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

    PHOTOBLEACHING BY HIGH POWER PULSES
    20.
    发明申请
    PHOTOBLEACHING BY HIGH POWER PULSES 审中-公开
    高功率脉冲激光漂白

    公开(公告)号：WO2008051478A2

    公开(公告)日：2008-05-02

    申请号：PCT/US2007022345

    申请日：2007-10-19

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  BANGALORE ARJUN

    Inventor： TUSCHEL DAVID ,  BANGALORE ARJUN

    IPC: G21G5/00 ,  G01J1/00 ,  G01J3/28 ,  G01J3/30 ,  G01J3/44 ,  G01N21/00

    CPC classification number: G01J3/44 ,  G01J3/10 ,  G01N21/274 ,  G01N21/65

    Abstract: A pulse photobleaching methodology wherein a monochromatic illumination (e.g., laser illumination) having a higher power intensity (photobleaching power) just below the photodamage threshold of a luminescent sample is initially used to significantly attenuate sample luminescence without photothermally destroying the sample material. Thereafter, the laser power density may be reduced to a significantly lower level (analytical power level) to carry out spectroscopic measurements (e.g., collection of Raman scattered photons) on the sample. In one embodiment, the laser illumination wavelength remains the same despite changes in laser power intensity. Some figures-of-merit may be computed from optical measurements made at the analytical power level to guide the photobleaching process. Sample-dependent combinations of laser power density and short exposure times may be obtained to significantly expedite photobleaching to assist in collection of sample spectral data in the field without a long wait. Portable spectroscopy systems employing pulse photobleaching may be devised for expeditious collection of spectral data from luminescent samples in the field.

    Abstract translation: 脉冲光漂白方法，其中最初使用具有刚好低于发光样品的光损伤阈值的较高功率强度（光漂白能力）的单色照明（例如，激光照明）来显着衰减样品发光而不光热地破坏样品材料。 此后，激光功率密度可以降低到显着较低的水平（分析能级），以对样品进行光谱测量（例如，拉曼散射光子的收集）。 在一个实施例中，激光照射波长保持相同，尽管激光功率强度的变化。 可以通过在分析功率级别进行的光学测量来计算一些数字值，以指导光漂白过程。 可以获得激光功率密度和短曝光时间的样品依赖组合，以显着加速光漂白，以帮助在现场收集样品光谱数据而不用长时间等待。 可以设计采用脉冲光漂白的便携式光谱系统，以便从现场的发光样品中快速收集光谱数据。

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