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    SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS
    1.
    发明专利
    SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS 未知

    公开(公告)号：CA2603927A1

    公开(公告)日：2006-10-19

    申请号：CA2603927

    申请日：2005-04-08

    Applicant: CHEMIMAGE CORP

    Inventor： TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: G01J3/00 ,  G01J3/12 ,  G01J3/44

    Abstract: The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array. The system includes an illumination source for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array for receiving said plurality of samples, the array having an external dimension such that the samples are within a simultaneous field of view of the optical device; an optical device for collecting the interacted photons and directing the photons to an imaging device, the imaging device simultaneously forming a plurality of images corresponding to each of the plurality of samples.

    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS
    2.
    发明专利
    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 未知

    公开(公告)号：CA2571765A1

    公开(公告)日：2006-01-12

    申请号：CA2571765

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP

    Inventor： TREADO PATRICK J ,  MAIER JOHN S ,  TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: G01J3/44 ,  G01N21/65

    Abstract: The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    METHOD AND APPARATUS FOR DENSE SPECTRUM UNMIXING AND IMAGE RECONSTRUCTION OF A SAMPLE
    4.
    发明申请
    METHOD AND APPARATUS FOR DENSE SPECTRUM UNMIXING AND IMAGE RECONSTRUCTION OF A SAMPLE 审中-公开
    用于密度谱合成和图像重建的方法和设备

    公开(公告)号：WO2007081692A3

    公开(公告)日：2008-10-02

    申请号：PCT/US2007000048

    申请日：2007-01-04

    Applicant: CHEMIMAGE CORP ,  WANG XINGHUA MARK ,  VOIGT THOMAS C

    Inventor： WANG XINGHUA MARK ,  VOIGT THOMAS C

    IPC: G01J3/04

    CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/024 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0294 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/44 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6417

    Abstract: In one embodiment, the disclosure relates to a method including: collecting photons from the sample having a plurality of regions to form a sample optical data set; selectively transmitting a first portion of the optical data set through a first of a plurality of apertures of an electro-optical shutter, each of the plurality of apertures optically communicating a portion of the optical data set; geometrically conforming the first portion of the optical data set for communication with a spectrometer opening; processing the conformed first portion of the optical data set at the spectrometer to obtain a spectrum for a first of the plurality of sample regions.

    Abstract translation: 在一个实施例中，本公开涉及一种方法，该方法包括：从具有多个区域的样本收集光子以形成样本光学数据集; 通过电光快门的多个孔中的第一个选择性地发送所述光学数据组的第一部分，所述多个孔中的每一个光学地传送所述光学数据组的一部分; 在几何上使光学数据组的第一部分与光谱仪开口通信; 处理光谱仪处的光学数据组的一致的第一部分以获得多个样品区域中的第一个的光谱。

    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS
    5.
    发明申请
    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
    动物化学成像生物细胞和其他物种

    公开(公告)号：WO2006005022A3

    公开(公告)日：2006-06-15

    申请号：PCT/US2005023638

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  VOIGT THOMAS C ,  TUSCHEL DAVID

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  VOIGT THOMAS C ,  TUSCHEL DAVID

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    Abstract: The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    Abstract translation: 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

    METHOD AND APPARATUS FOR COUNTERFEITING PROTECTION
    6.
    发明申请
    METHOD AND APPARATUS FOR COUNTERFEITING PROTECTION 审中-公开

    公开(公告)号：WO2007078936A3

    公开(公告)日：2008-04-17

    申请号：PCT/US2006048381

    申请日：2006-12-20

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  VOIGT THOMAS C

    Inventor： TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: H04K1/00

    CPC classification number: G06K19/10

    Abstract: The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

    SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS
    8.
    发明公开
    SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS 审中-公开
    系统和方法微阵列的化学成像

    公开(公告)号：EP1866613A4

    公开(公告)日：2009-06-03

    申请号：EP05735084

    申请日：2005-04-08

    Applicant: CHEMIMAGE CORP

    Inventor： TUSCHEL DAVID ,  VOIGT THOMAS C

    IPC: G01J3/00 ,  G01J3/12 ,  G01J3/44

    CPC classification number: G01J3/42 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/65

    Abstract: The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array (300). The system includes an illumination source (310) for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array (300) for receiving said plurality of samples, the array (300) having an external dimension such that the samples are within a simultaneous field of view of the optical device (320); an optical device (320) for collecting the interacted photons and directing the photons to an imaging device (350), the imaging device (350) simultaneously forming a plurality of images corresponding to each of the plurality of samples.

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