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    11.
    发明专利
    未知

    公开(公告)号：DK457780A

    公开(公告)日：1981-05-01

    申请号：DK457780

    申请日：1980-10-29

    Applicant: CIBA GEIGY AG

    Inventor： AUFDERHAAR E

    IPC: C07D223/26 ,  C07D223/22 ,  C07D223/28 ,  C07D

    Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form. The process is illustrated by the following reaction scheme: +TR The invention relates also to new intermediates produced in these reactions.

    PROCESS FOR PREPARING NEW INTERMEDIATE USABLE IN PROCESS FOR PREPARING OXO COMPOUNDS
    17.
    发明专利
    PROCESS FOR PREPARING NEW INTERMEDIATE USABLE IN PROCESS FOR PREPARING OXO COMPOUNDS 未知

    公开(公告)号：YU45522B

    公开(公告)日：1992-05-28

    申请号：YU137289

    申请日：1989-07-10

    Applicant: CIBA GEIGY AG

    Inventor： AUFDERHAAR E

    IPC: C07D223/26 ,  C07D223/22 ,  C07D223/28 ,  C07D487/00 ,  A61K31/33

    Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form. The process is illustrated by the following reaction scheme: +TR The invention relates also to new intermediates produced in these reactions.

    PROCESS FOR PREPARING NEW INTERMEDIATE USABLE IN PROCESS FOR PREPARING OXO COMPOUNDS
    18.
    发明专利
    PROCESS FOR PREPARING NEW INTERMEDIATE USABLE IN PROCESS FOR PREPARING OXO COMPOUNDS 未知

    公开(公告)号：YU136689A

    公开(公告)日：1990-02-28

    申请号：YU136689

    申请日：1989-07-10

    Applicant: CIBA GEIGY AG

    Inventor： AUFDERHAAR E

    IPC: C07D223/26 ,  C07D223/22 ,  C07D223/28

    Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form. The process is illustrated by the following reaction scheme: +TR The invention relates also to new intermediates produced in these reactions.

    19.
    发明专利
    未知

    公开(公告)号：SE444314B

    公开(公告)日：1986-04-07

    申请号：SE7804058

    申请日：1978-04-11

    Applicant: CIBA GEIGY AG

    Inventor： AUFDERHAAR E ,  GALLAY J-J ,  KUHNE M ,  MEYER A ,  RECHSTEINER O ,  SCHELLENBAUM M ,  FUMEAUX J-P

    IPC: A01N43/52 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/00 ,  C07D235/28 ,  C07D233/28

    Abstract: Benzimidazole derivatives of the formula in which R and R1 independently of one another are each hydrogen, an alkanoyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms, an alkylsulphonyl group having 1 to 4 carbon atoms, a benzoyl group, a phenylsulphonyl group or a p-methylphenylsulphonyl group; R2 and R4 independently of one another are each hydrogen, halogen or a methyl group, R3 is hydrogen, halogen, a methyl group or a methoxy group; X is oxygen or sulphur; Y is halogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a methylthio group, a methylsulphinyl group, a methylsulphonyl group, a trifluoromethyl group, a nitro group, a hydroxyl group, a cyano group or an acetyl group; and m is 0, 1, 2 or 3; and if one of the two radicals R or R1 is hydrogen, the position of the other of these radicals on the N atoms cannot be clearly established, including, when at least one of the two radicals R or R1 is hydrogen, the possible tautomeric compounds of the formula I; and the disulphides obtainable by oxidation of compounds of the formula I. The compounds are useful for combating helminths in domestic animals and productive animals.

    PROCESS FOR PREPARING BENZOIMIDAZOLE DERIVATIVES
    20.
    发明专利
    PROCESS FOR PREPARING BENZOIMIDAZOLE DERIVATIVES 未知

    公开(公告)号：YU85878A

    公开(公告)日：1984-02-29

    申请号：YU85878

    申请日：1978-04-11

    Applicant: CIBA GEIGY AG

    Inventor： AUFDERHAAR E ,  GALLAY J J ,  KUEHNE M ,  MEYER A ,  RECHSTEINER O ,  SCHELLENBAUM M ,  FUMEAUX J P

    IPC: A01N43/52 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/00 ,  C07D235/28 ,  C07D235/04 ,  A61K31/33

    Abstract: Benzimidazole derivatives of the formula in which R and R1 independently of one another are each hydrogen, an alkanoyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms, an alkylsulphonyl group having 1 to 4 carbon atoms, a benzoyl group, a phenylsulphonyl group or a p-methylphenylsulphonyl group; R2 and R4 independently of one another are each hydrogen, halogen or a methyl group, R3 is hydrogen, halogen, a methyl group or a methoxy group; X is oxygen or sulphur; Y is halogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a methylthio group, a methylsulphinyl group, a methylsulphonyl group, a trifluoromethyl group, a nitro group, a hydroxyl group, a cyano group or an acetyl group; and m is 0, 1, 2 or 3; and if one of the two radicals R or R1 is hydrogen, the position of the other of these radicals on the N atoms cannot be clearly established, including, when at least one of the two radicals R or R1 is hydrogen, the possible tautomeric compounds of the formula I; and the disulphides obtainable by oxidation of compounds of the formula I. The compounds are useful for combating helminths in domestic animals and productive animals.

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