公开(公告)号：HRP940076B1

公开(公告)日：1996-04-30

申请号：HRP940076

申请日：1994-02-10

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E

IPC: A61K31/33 ,  A61K31/55 ,  C07D223/22 ,  C07D487/00

公开(公告)号：YU45519B

公开(公告)日：1992-05-28

申请号：YU136489

申请日：1989-07-10

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E

IPC: C07D223/26 ,  C07D223/22 ,  C07D223/28 ,  C07D487/00 ,  A61K31/23

Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form. The process is illustrated by the following reaction scheme: +TR The invention relates also to new intermediates produced in these reactions.

公开(公告)号：SE7804058A

公开(公告)日：1978-10-13

申请号：SE7804058

申请日：1978-04-11

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E ,  GALLAY J J ,  KUHNE M ,  MEYER A ,  RECHSTEINER O ,  SCHELLENBAUM M ,  FUMEAUX J-P

IPC: A01N43/52 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/00 ,  C07D235/28

CPC classification number: C07D235/28 ,  A01N43/52

公开(公告)号：ZA763995B

公开(公告)日：1978-03-29

申请号：ZA763995

申请日：1976-07-02

Applicant: CIBA GEIGY AG

Inventor： SCHWEIZER E ,  VARSANYI D ,  AUFDERHAAR E

IPC: A61K31/27 ,  A61P33/00 ,  A61P33/10 ,  C07C67/00 ,  C07C325/00 ,  C07C333/24 ,  C07C

公开(公告)号：ZA7500392B

公开(公告)日：1976-01-28

申请号：ZA7500392

申请日：1975-01-21

Applicant: CIBA GEIGY AG

Inventor： TRABER W ,  AUFDERHAAR E

IPC: A23K1/16 ,  C07D235/10 ,  A61K ,  C07D

CPC classification number: C07D235/10

公开(公告)号：NO750172L

公开(公告)日：1975-08-18

申请号：NO750172

申请日：1975-01-21

Applicant: CIBA GEIGY AG

Inventor： TRABER W ,  AUFDERHAAR E

IPC: A23K1/16 ,  C07D235/10 ,  A23K

公开(公告)号：BR7401719D0

公开(公告)日：1974-11-05

申请号：BR171974

申请日：1974-03-07

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E ,  KRISTINSSON H ,  HUBELE A

IPC: C07D471/04 ,  C07D57/04 ,  A61K27/00

公开(公告)号：HRP940079B1

公开(公告)日：1996-04-30

申请号：HRP940079

申请日：1994-02-10

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E

IPC: A61K31/33 ,  B01J23/06 ,  B01J23/14 ,  B01J23/745 ,  B01J37/16 ,  B01J37/18 ,  C07D223/22 ,  C07D487/00

公开(公告)号：YU45520B

公开(公告)日：1992-05-28

申请号：YU136589

申请日：1989-07-10

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E

IPC: C07D223/26 ,  C07D223/22 ,  C07D223/28 ,  C07D233/22 ,  C07D487/00 ,  A61K31/33

Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form. The process is illustrated by the following reaction scheme: +TR The invention relates also to new intermediates produced in these reactions.

公开(公告)号：YU136489A

公开(公告)日：1990-02-28

申请号：YU136489

申请日：1989-07-10

Applicant: CIBA GEIGY AG

Inventor： AUFDERHAAR E

IPC: C07D223/26 ,  C07D223/22 ,  C07D223/28 ,  C07D225/04 ,  C07D487/00 ,  A61K31/33

Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form. The process is illustrated by the following reaction scheme: +TR The invention relates also to new intermediates produced in these reactions.