公开(公告)号：EP0619738A4

公开(公告)日：1996-07-03

申请号：EP93900793

申请日：1992-12-01

Applicant: COR THERAPEUTICS INC

Inventor： RAMAKRISHNAN VANITHA ,  ESCOBEDO MARIA A ,  FRETTO LARRY J

IPC: A61K39/395 ,  A61K9/20 ,  A61K38/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/18 ,  C12N15/09 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  G01N33/566 ,  G01N33/577 ,  A61K37/00 ,  A61K37/04 ,  A61K39/00 ,  C07K15/28 ,  C12P21/00

CPC classification number: C07K16/2863 ,  A61K38/00 ,  C07K14/71 ,  C07K2317/34

公开(公告)号：CA2100559C

公开(公告)日：2007-05-22

申请号：CA2100559

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

IPC: A61K39/395 ,  C12N15/18 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  G01N33/74

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular re-gion domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are pro-vided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.

公开(公告)号：ES2147729T3

公开(公告)日：2000-10-01

申请号：ES92906305

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  UNIV CALIFORNIA

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/475 ,  A61K38/18

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：CA2318199A1

公开(公告)日：1999-07-22

申请号：CA2318199

申请日：1999-01-08

Applicant: COR THERAPEUTICS INC

Inventor： LAIBELMAN ALAN M ,  JANTZEN HANS-MICHAEL ,  CONLEY PAMELA B ,  FRETTO LARRY J ,  SCARBOROUGH ROBERT M

IPC: A61K31/549 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/54 ,  C07D277/00 ,  C07D285/00

Abstract: The invention relates to novel compounds of formula (I) containing fused heterocyclic ring systems which are effective platelet ADP receptor inhibitors. Such compounds including pharmaceutically acceptable salts are useful in various pharmaceutical compositions for the prevention and/or treatment of cardiovascular disease particularly those related to thrombosis.

公开(公告)号：NZ241480A

公开(公告)日：1993-09-27

申请号：NZ24148092

申请日：1992-01-31

Applicant: COR THERAPEUTICS INC ,  ESCORBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A ,  ESCORBEDO JAIME A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12N15/63 ,  C07K15/06 ,  C07K15/28 ,  C07H21/04 ,  G01N33/50

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：AU1411092A

公开(公告)日：1992-09-07

申请号：AU1411092

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C07H15/12 ,  C07H17/00 ,  C07K3/00 ,  C07K13/00 ,  C07K15/00 ,  C07K17/00 ,  A01N1/02 ,  C12Q1/00 ,  C12Q1/68 ,  C12N5/00

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：AU709177B2

公开(公告)日：1999-08-26

申请号：AU5580496

申请日：1996-06-03

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：PL171920B1

公开(公告)日：1997-06-30

申请号：PL30402692

申请日：1992-12-01

Applicant: COR THERAPEUTICS INC

Inventor： RAMAKRISHNAN VANITHA ,  ESCOBEDO MARIA A ,  FRETTO LARRY J

IPC: A61K39/395 ,  A61K9/20 ,  A61K38/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/18 ,  C12N15/09 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  G01N33/566 ,  G01N33/577 ,  A61K39/385

公开(公告)号：AU672377B2

公开(公告)日：1996-10-03

申请号：AU3232893

申请日：1992-12-01

Applicant: COR THERAPEUTICS INC

Inventor： RAMAKRISHNAN VANITHA ,  ESCOBEDO MARIA A ,  FRETTO LARRY J

IPC: A61K39/395 ,  A61K9/20 ,  A61K38/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/18 ,  C12N15/09 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  G01N33/566 ,  G01N33/577 ,  C07K15/12

公开(公告)号：NZ246242A

公开(公告)日：1996-01-26

申请号：NZ24624292

申请日：1992-12-01

Applicant: COR THERAPEUTICS INC

Inventor： RAMAKRISHNAN VANITHA ,  ESCOBEDO MARIA A ,  FRETTO LARRY J

IPC: A61K39/395 ,  A61K9/20 ,  A61K38/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/18 ,  C12N15/09 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  G01N33/566 ,  G01N33/577 ,  C12N5/12