公开(公告)号：AU2017228803A1

公开(公告)日：2018-08-09

申请号：AU2017228803

申请日：2017-02-17

Applicant: CYTOSORBENTS CORP

Inventor： GRUDA MARYANN ,  O'SULLIVAN PAMELA ,  GULIASHVILI TAMAZ ,  SCHEIRER ANDREW ,  GOLOBISH THOMAS ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61K9/18 ,  A61M1/00 ,  B01J20/22 ,  B01J20/28 ,  B01J20/285

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

公开(公告)号：AU2017228803B2

公开(公告)日：2022-09-08

申请号：AU2017228803

申请日：2017-02-17

Applicant: CYTOSORBENTS CORP

Inventor： GRUDA MARYANN ,  O'SULLIVAN PAMELA ,  GULIASHVILI TAMAZ ,  SCHEIRER ANDREW ,  GOLOBISH THOMAS ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61K9/18 ,  A61M1/00 ,  B01J20/22 ,  B01J20/28 ,  B01J20/285

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

公开(公告)号：RU2742768C2

公开(公告)日：2021-02-10

申请号：RU2018114640

申请日：2016-10-21

Applicant: CYTOSORBENTS CORP

Inventor： GOLOBISH THOMAS ,  GRUDA MARYANN ,  GULIASHVILI TAMAZ ,  O'SULLIVAN PAMELA ,  SCHEIRER ANDREW ,  DAN VI ,  YOUNG WEI-TAI ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61K31/795 ,  A61K47/20 ,  A61M5/165

Abstract: Группаизобретенийотноситсяк областиполимернойхимии, аименнок биосовместимойполимернойсистеме, способнойк адсорбциибелковыхтоксинов, воспалительныхмедиаторови положительнозаряженныхионов, кспособуперфузии, атакжек устройствудляудалениябелковыхтоксинов, воспалительныхмедиаторови положительнозаряженныхионовизфизиологическойжидкости. Биосовместимаяполимернаясистемасодержитпоменьшеймереодинполимер, имеющийформусверхсшитогоилимакросетчатогопористогополимера, сульфированногов мягкихусловиях, прикоторыхсохраняетсяостаточнаяфункциональностьнепрореагировавшихдвойныхсвязейи хлорметильныхгрупп, ибиосовместимоепокрытие. Способперфузиивключаетпропусканиефизиологическойжидкостинапрямуюилис помощьюподходящегоэкстракорпоральногоконтурачерезустройство, содержащеебиосовместимуюполимернуюсистему. Устройствовключаетуплотненныйслойгранул, содержащихбиосовместимуюполимернуюсистему, впроточномконтейнере. Группаизобретенийобеспечиваетсозданиебиосовместимогосорбирующегоматериаладляэффективногоудаленияизфизиологическихжидкостейбелковыхтоксинов, воспалительныхмедиаторови положительнозаряженныхионоводновременно, безущербадляихсвязывающейспособности. 3 н. и 20 з.п. ф-лы, 11 ил., 23 табл., 8 пр.

公开(公告)号：CA3025321A1

公开(公告)日：2017-11-30

申请号：CA3025321

申请日：2017-05-18

Applicant: CYTOSORBENTS CORP

Inventor： GULIASHVILI TAMAZ ,  GOLOBISH THOMAS ,  GRUDA MARYANN ,  O'SULLIVAN PAMELA ,  SCHEIRER ANDREW ,  CAPPONI VINCENT ,  CHAN PHILLIP ,  YOUNG WEI-TAI

IPC: B01J20/32 ,  B01D15/34 ,  B01J20/28

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：CA3013636A1

公开(公告)日：2017-09-14

申请号：CA3013636

申请日：2017-02-17

Applicant: CYTOSORBENTS CORP

Inventor： GRUDA MARYANN ,  O'SULLIVAN PAMELA ,  GULIASHVILI TAMAZ ,  SCHEIRER ANDREW ,  GOLOBISH THOMAS ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61K9/18 ,  A61M1/00 ,  B01J20/22 ,  B01J20/28 ,  B01J20/285

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

公开(公告)号：CA3001698A1

公开(公告)日：2017-04-27

申请号：CA3001698

申请日：2016-10-21

Applicant: CYTOSORBENTS CORP

Inventor： GOLOBISH THOMAS ,  GRUDA MARYANN ,  GULIASHVILI TAMAZ ,  O'SULLIVAN PAMELA ,  SCHEIRER ANDREW ,  DAN VI ,  YOUNG WEI-TAI ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61M5/165 ,  A61K31/795 ,  A61K47/20 ,  A61M1/34

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：AU2018246007C1

公开(公告)日：2022-06-23

申请号：AU2018246007

申请日：2018-03-22

Applicant: CYTOSORBENTS CORP

Inventor： YOUNG WEI-TAI ,  GULIASHVILI TAMAZ ,  SCHEIRER ANDREW ,  VICHARE JOSH ,  KOVACS TIMOTHY ,  GRUDA MARYANN ,  GOLOBISH THOMAS ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  B01D15/00 ,  B01D61/00

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：AU2018246007B2

公开(公告)日：2022-03-17

申请号：AU2018246007

申请日：2018-03-22

Applicant: CYTOSORBENTS CORP

Inventor： YOUNG WEI-TAI ,  GULIASHVILI TAMAZ ,  SCHEIRER ANDREW ,  VICHARE JOSH ,  KOVACS TIMOTHY ,  GRUDA MARYANN ,  GOLOBISH THOMAS ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  B01D15/00 ,  B01D61/00

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：AU2017272021B2

公开(公告)日：2021-09-02

申请号：AU2017272021

申请日：2017-05-18

Applicant: CYTOSORBENTS CORP

Inventor： GULIASHVILI TAMAZ ,  GOLOBISH THOMAS ,  GRUDA MARYANN ,  O'SULLIVAN PAMELA ,  SCHEIRER ANDREW ,  CAPPONI VINCENT ,  CHAN PHILLIP ,  YOUNG WEI-TAI

IPC: B01J20/32 ,  B01D15/34 ,  B01J20/28

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：ES2823582T3

公开(公告)日：2021-05-07

申请号：ES13810619

申请日：2013-06-28

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP ,  CAPPONI VINCENT ,  GOLOBISH THOMAS ,  ALI HUMAYRA

IPC: A61M1/34 ,  A61K9/16 ,  A61K31/765 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28 ,  C08F299/00 ,  C08J9/26 ,  C09K23/38 ,  C09K23/48 ,  C09K23/52

Abstract: Un sorbente para su uso en un método para tratar la contaminación por una o más toxinas en un sujeto, en donde el sorbente es capaz de absorber la toxina y comprende una pluralidad de poros que varían de 50Å a 40.000Å con un volumen de poros de 0,5 cc/g a 5,0 cc/g, dicho sorbente teniendo un tamaño de 0,05 mm a 2 cm; en donde el sorbente tiene una estructura de poro tal que el volumen de poros total del tamaño de poro en el intervalo de 50 Å a 40.000 Å es mayor de 0,5 cc/g a 5,0 cc/g de sorbente seco; en donde: (i) la proporción de volumen de poros total de diámetro de poro en el intervalo de 50Å a 40.000Å con el volumen de poros total del diámetro de poro en el intervalo de 100Å a 1.000Å del sorbente es más pequeño de 3:1; (ii) la proporción de volumen de poros total de diámetro de poro en el intervalo de 50Å a 40.000Å con el volumen de poros total del diámetro de poro en el intervalo de 1.000Å a 10.000Å del sorbente es más pequeño de 2:1; o (iii) la proporción de volumen de poros total de diámetro de poro en el intervalo de 50Å a 40.000Å con el volumen de poros total del diámetro de poro en el intervalo de 10.000Å a 40.000Å del sorbente es más pequeño de 3:1; en donde dicha toxina es una toxina producida por un microorganismo que puede comprender una o más bacterias, virus, hongos o parásitos; y en donde la toxina comprende proteínas, péptidos, carbohidratos, lípidos, ácidos nucleicos, o combinaciones de los mismos.