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公开(公告)号：AU2017228803B2
公开(公告)日：2022-09-08
申请号：AU2017228803
申请日：2017-02-17
Applicant: CYTOSORBENTS CORP
Inventor： GRUDA MARYANN , O'SULLIVAN PAMELA , GULIASHVILI TAMAZ , SCHEIRER ANDREW , GOLOBISH THOMAS , CAPPONI VINCENT , CHAN PHILLIP
IPC: A61K9/18 , A61M1/00 , B01J20/22 , B01J20/28 , B01J20/285
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.
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Patent Agency Ranking
公开(公告)号：RU2742768C2
公开(公告)日：2021-02-10
申请号：RU2018114640
申请日：2016-10-21
Applicant: CYTOSORBENTS CORP
Inventor： GOLOBISH THOMAS , GRUDA MARYANN , GULIASHVILI TAMAZ , O'SULLIVAN PAMELA , SCHEIRER ANDREW , DAN VI , YOUNG WEI-TAI , CAPPONI VINCENT , CHAN PHILLIP
IPC: A61K31/795 , A61K47/20 , A61M5/165
Abstract: Группаизобретенийотноситсяк областиполимернойхимии, аименнок биосовместимойполимернойсистеме, способнойк адсорбциибелковыхтоксинов, воспалительныхмедиаторови положительнозаряженныхионов, кспособуперфузии, атакжек устройствудляудалениябелковыхтоксинов, воспалительныхмедиаторови положительнозаряженныхионовизфизиологическойжидкости. Биосовместимаяполимернаясистемасодержитпоменьшеймереодинполимер, имеющийформусверхсшитогоилимакросетчатогопористогополимера, сульфированногов мягкихусловиях, прикоторыхсохраняетсяостаточнаяфункциональностьнепрореагировавшихдвойныхсвязейи хлорметильныхгрупп, ибиосовместимоепокрытие. Способперфузиивключаетпропусканиефизиологическойжидкостинапрямуюилис помощьюподходящегоэкстракорпоральногоконтурачерезустройство, содержащеебиосовместимуюполимернуюсистему. Устройствовключаетуплотненныйслойгранул, содержащихбиосовместимуюполимернуюсистему, впроточномконтейнере. Группаизобретенийобеспечиваетсозданиебиосовместимогосорбирующегоматериаладляэффективногоудаленияизфизиологическихжидкостейбелковыхтоксинов, воспалительныхмедиаторови положительнозаряженныхионоводновременно, безущербадляихсвязывающейспособности. 3 н. и 20 з.п. ф-лы, 11 ил., 23 табл., 8 пр.
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公开(公告)号：CA3115831A1
公开(公告)日：2020-07-30
申请号：CA3115831
申请日：2019-12-02
Applicant: CYTOSORBENTS CORP
Inventor： GULIASHVILI TAMAZ , GRUDA MARYANN , GOLOBISH THOMAS , JAMES DAVID , RUGGEBERG KARL-GUSTAV , O'SULLIVAN PAM , PATTERSON SARAH
Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1 5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1 5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.
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14.发明专利
公开(公告)号：CA3025321A1
公开(公告)日：2017-11-30
申请号：CA3025321
申请日：2017-05-18
Applicant: CYTOSORBENTS CORP
Inventor： GULIASHVILI TAMAZ , GOLOBISH THOMAS , GRUDA MARYANN , O'SULLIVAN PAMELA , SCHEIRER ANDREW , CAPPONI VINCENT , CHAN PHILLIP , YOUNG WEI-TAI
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：CA3013636A1
公开(公告)日：2017-09-14
申请号：CA3013636
申请日：2017-02-17
Applicant: CYTOSORBENTS CORP
Inventor： GRUDA MARYANN , O'SULLIVAN PAMELA , GULIASHVILI TAMAZ , SCHEIRER ANDREW , GOLOBISH THOMAS , CAPPONI VINCENT , CHAN PHILLIP
IPC: A61K9/18 , A61M1/00 , B01J20/22 , B01J20/28 , B01J20/285
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.
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公开(公告)号：CA3001698A1
公开(公告)日：2017-04-27
申请号：CA3001698
申请日：2016-10-21
Applicant: CYTOSORBENTS CORP
Inventor： GOLOBISH THOMAS , GRUDA MARYANN , GULIASHVILI TAMAZ , O'SULLIVAN PAMELA , SCHEIRER ANDREW , DAN VI , YOUNG WEI-TAI , CAPPONI VINCENT , CHAN PHILLIP
IPC: A61M5/165 , A61K31/795 , A61K47/20 , A61M1/34
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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