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11.发明授权公开(公告)号：US12163891B2
公开(公告)日：2024-12-10
申请号：US17627287
申请日：2020-07-16
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey
Abstract: A system and method for mapping a tissue sample is provided. The system includes a light source, a scanner, a digital mirror device (DMD), a light detector, and an analyzer. The DMD has an array of micromirrors. The analyzer controls the light source, controls the scanner, controls the DMD to have on-state micromirrors aligned with a light beam, and other micromirrors in an off-state. The on-state micromirrors direct the light beam to a tissue sample. The analyzer assigns one or more location codes to the on-state micromirrors, controls the light detector to receive Raman light emitted from the tissue sample, correlates the location codes of the on-state micromirrors with light detector signals representative of the Raman emitted light, and produces a spatial map of the Raman emitted light.
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12.发明公开公开(公告)号：US20240310617A1
公开(公告)日：2024-09-19
申请号：US18575708
申请日：2022-06-30
Applicant: CytoVeris Inc.
Inventor： David Fournier , Alan Kersey
CPC classification number: G02B21/16 , G01N21/6458 , G01N21/6486 , G02B21/06 , G02B21/361
Abstract: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.
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公开(公告)号：US12038383B2
公开(公告)日：2024-07-16
申请号：US17688776
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
CPC classification number: G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0086 , G01J3/44 , G01N21/6486 , G16H50/20
Abstract: A method and system for identifying tissue types is provided that utilizes Raman scattered light in the high wavenumber region (HWN) of Raman spectrum. The method includes: a) interrogating a tissue specimen with at least one wavelength of light, the wavelength of light operable to produce Raman scattered light in a HWN region of Raman spectrum from the tissue specimen; b) producing signal data representative of the Raman scattering, the signal data relating signal intensity as a function of wavenumber within the HWN region; c) fitting a curve to a portion of the signal data attributable to a HWN peak within the signal data, for a plurality of different HWN peaks; d) determining a plurality of characteristics of each fitted curve; and e) determining a tissue type using the determined characteristics and stored collective data representative of fitted peaks in the HWN region of a plurality of different tissue types.
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公开(公告)号：US20220283092A1
公开(公告)日：2022-09-08
申请号：US17688776
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
IPC: G01N21/65
Abstract: A method and system for identifying tissue types is provided that utilizes Raman scattered light in the high wavenumber region (HWN) of Raman spectrum. The method includes: a) interrogating a tissue specimen with at least one wavelength of light, the wavelength of light operable to produce Raman scattered light in a HWN region of Raman spectrum from the tissue specimen; b) producing signal data representative of the Raman scattering, the signal data relating signal intensity as a function of wavenumber within the HWN region; c) fitting a curve to a portion of the signal data attributable to a HWN peak within the signal data, for a plurality of different HWN peaks; d) determining a plurality of characteristics of each fitted curve; and e) determining a tissue type using the determined characteristics and stored collective data representative of fitted peaks in the HWN region of a plurality of different tissue types.
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15.发明公开公开(公告)号：US20240011969A1
公开(公告)日：2024-01-11
申请号：US18271023
申请日：2022-01-05
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , David Fournier , Patrick Curry , Alan Kersey
IPC: G01N33/483 , G01N21/64
CPC classification number: G01N33/4833 , G01N21/6486 , A61B10/00
Abstract: A system and method for analyzing bladder tissue sample is provided that includes an excitation light source, a photodetector, an optical filter, and a system controller. The excitation light source produces excitation lights centered on a distinct wavelengths. At least one of the wavelengths produces autofluorescence emissions from one or more biomolecules, and at least one of the wavelengths produces diffuse reflectance signals. The photodetector detects at least one of the autofluorescence emissions or diffuse reflectance signals and produces signals representative thereof. The optical filter filters at least one of autofluorescence emissions or the diffuse reflectance signals. The system controller communicates with the system components and a memory storing instructions. The instructions cause the system controller to control the excitation light unit, receive and process the photodetector signals, produce a signal image, and analyze the tissue sample to determine the presence of detrusor muscle tissue.
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Patent Agency Ranking
16.发明公开公开(公告)号：US20230296519A1
公开(公告)日：2023-09-21
申请号：US18122544
申请日：2023-03-16
Applicant: CytoVeris Inc.
Inventor： Alan Kersey
CPC classification number: G01N21/6458 , G01N1/2813 , G01N21/6486 , G01N2201/126
Abstract: A method of analyzing a tissue specimen is provided. The method includes imaging a tissue specimen to produce autofluorescence images acquired at different excitation and emission wavelengths, and/or reflectance images, using data produced during the imaging to identify one or more regions of interest within the tissue specimen, and performing an omics profiling on the identified one or more regions of interest within the tissue specimen to produce information relating to the tissue specimen.
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17.发明申请公开(公告)号：US20220317046A1
公开(公告)日：2022-10-06
申请号：US17627287
申请日：2020-07-16
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey
IPC: G01N21/65 , G02B26/10 , G02B26/08 , G01N33/483
Abstract: A system and method for mapping a tissue sample is provided. The system includes a light source, a scanner, a digital mirror device (DMD), a light detector, and an analyzer. The DMD has an array of micromirrors. The analyzer controls the light source, controls the scanner, controls the DMD to have on-state micromirrors aligned with a light beam, and other micromirrors in an off-state. The on-state micromirrors direct the light beam to a tissue sample. The analyzer assigns one or more location codes to the on-state micromirrors, controls the light detector to receive Raman light emitted from the tissue sample, correlates the location codes of the on-state micromirrors with light detector signals representative of the Raman emitted light, and produces a spatial map of the Raman emitted light.
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18.发明申请公开(公告)号：US20220284603A1
公开(公告)日：2022-09-08
申请号：US17687283
申请日：2022-03-04
Applicant: CytoVeris Inc.
Inventor： David Fournier , Kevin Didden , Alan Kersey
Abstract: A system and method of producing an image-based registration of an excised tissue specimen for histopathological examination is provided. The method includes: a) producing a three-dimensional image of an excised tissue specimen having a plurality of surfaces at a first location, the excised tissue specimen having an in-vivo orientation prior to being excised; b) producing orientation information relating to the orientation of the plurality of surfaces of the excised tissue specimen relative to the in-vivo orientation of the tissue specimen prior to being excised; c) wherein the excised tissue specimen is transported to a second location and is positioned; and d) using the three-dimensional image and the orientation information to confirm the excised tissue specimen positioned at the second location is in the in-vivo orientation.
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公开(公告)号：US11821841B2
公开(公告)日：2023-11-21
申请号：US17688792
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
CPC classification number: G01N21/65 , G01N21/6486 , A61B5/0075
Abstract: A method and system for classifying a tissue specimen is provided. The method includes: a) interrogating a tissue specimen with a first interrogation light; b) detecting first light from the tissue specimen resulting from the interrogation, wherein the first light includes a first scattered light component and a first fluorescence light component, and producing first signals; c) interrogating the tissue specimen with a second interrogation light at a second excitation wavelength, wherein the first and second excitation wavelengths are within about 2 nm of each other; d) detecting second light from the tissue specimen resulting from the interrogation, wherein the second light includes a second scattered light component and a second fluorescence light component, and producing second signals; e) determining a difference between the first and second lights; f) determining a fluorescence spectrum produced by the interrogation of the tissue specimen; and g) classifying the tissue specimen.
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公开(公告)号：US20230324300A1
公开(公告)日：2023-10-12
申请号：US18126117
申请日：2023-03-24
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
IPC: G01N21/64
CPC classification number: G01N21/6456 , G01N21/6486
Abstract: A method of and a system for analyzing a tissue sample is provided. The method includes a) imaging a tissue specimen to produce multispectral images of the tissue specimen, the multispectral images including autofluorescence (AF) images and reflectance images acquired at different excitation and emission wavelengths; b) using the multispectral images to produce a plurality of biomolecular barcodes (BBCs) attributable to the tissue specimen; and c) analyzing the tissue specimen to identify a type of the tissue specimen, the analyzing using the plurality of BBCs attributable to the tissue specimen and a plurality of predetermined BBCs based on known tissue types.
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