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公开(公告)号：US20220196557A1
公开(公告)日：2022-06-23
申请号：US17601631
申请日：2020-04-06
Applicant: CYTOVERIS INC.
Inventor： Guoan Zheng , Alan Kersey , Rishikesh Pandey , David Fournier
Abstract: An apparatus and method for analyzing a tissue sample to provide depth-selective information includes at least one light source, collection light optics, and a light detector. The light source is configured to produce a light beam having one or more wavelengths of light that cause a tissue sample to produce Raman light signals upon interrogation of the tissue sample. The light beam is oriented to impinge on an exposed surface of the tissue sample at a point of incidence (POI), and oriented so that the light beam enters the tissue sample at an oblique angle relative to the exposed surface of the tissue sample. The collection light optics are configured to collect the Raman light signals emanating from the tissue sample at one or more predetermined lateral distances from the point of incidence. The light detector is configured to receive the Raman light signals from the collection light optics.
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2.发明公开公开(公告)号：US20240310617A1
公开(公告)日：2024-09-19
申请号：US18575708
申请日：2022-06-30
Applicant: CytoVeris Inc.
Inventor： David Fournier , Alan Kersey
CPC classification number: G02B21/16 , G01N21/6458 , G01N21/6486 , G02B21/06 , G02B21/361
Abstract: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.
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公开(公告)号：US11686684B2
公开(公告)日：2023-06-27
申请号：US17513824
申请日：2021-10-28
Applicant: CytoVeris Inc.
Inventor： David Fournier , Rishikesh Pandey
IPC: G01N21/65 , A61B5/00 , G01N33/543 , G01J3/44
CPC classification number: G01N21/658 , A61B5/0075 , G01J3/4412 , G01N33/54346
Abstract: A system and method for assaying high and low abundant biomolecules within a biological fluid sample is provided. The method includes: a) placing a biological fluid sample in contact with a first nanostructure surface; b) interrogating the sample with a light source, the sample in contact with the first nanostructure surface, the interrogation using a SERS technique; c) detecting an enhanced Raman scattering from at least one high abundant biomolecule type and producing first signals representative thereof; d) placing the sample in contact with a second nanostructure surface having a targeting agent that targets a low abundant biomolecule; e) interrogating the sample with the light source using the SERS technique; f) detecting the enhanced Raman scattering from the low abundant biomolecules and producing second signals representative thereof; and g) assaying the biological fluid sample using the first signals and the second signals.
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公开(公告)号：US20210310868A1
公开(公告)日：2021-10-07
申请号：US17222858
申请日：2021-04-05
Applicant: CytoVeris Inc.
Inventor： Gary Root , David Fournier , Rishikesh Pandey
Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.
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公开(公告)号：US20230366795A1
公开(公告)日：2023-11-16
申请号：US18196411
申请日：2023-05-11
Applicant: CytoVeris Inc.
Inventor： Morgan McNamara , David Fournier , Noel Diagneault , Michael A. Sapack , Gary Root
CPC classification number: G01N1/36 , A61B90/39 , A61B90/90 , A61B2090/3937 , B01L2200/141 , B01L2300/123 , B01L2300/041 , B01L2300/021 , B01L2300/12
Abstract: An apparatus for holding a tissue specimen during imaging is provided. The tissue specimen has a 3D geometry and a region of interest. The apparatus includes a cover panel and a specimen support structure. The cover panel has upper and bottom panel surfaces and a viewing aperture that extends between the upper and bottom panel surfaces. The specimen support structure is configured to support the tissue specimen in an imaging orientation. The specimen support structure is configured to permit alignment of the tissue specimen ROI with the viewing aperture. The apparatus is configurable in a secured configuration in which the specimen support structure is positionally fixed relative to the cover panel, the tissue specimen ROI is exposed through the viewing aperture for imaging, and the tissue specimen ROI is held motionless relative to the cover panel.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20230266170A1
公开(公告)日：2023-08-24
申请号：US18017812
申请日：2021-07-26
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , David Fournier , Rishikesh Pandey , Gary Root
CPC classification number: G01J3/44 , G01J3/12 , G01J3/0208 , G01J3/08 , G01J3/10 , G01J3/0218 , G01J2003/102 , G01J2003/1213 , G01N21/65
Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.
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7.发明申请公开(公告)号：US20220079450A1
公开(公告)日：2022-03-17
申请号：US17478513
申请日：2021-09-17
Applicant: CytoVeris Inc.
Inventor： David Fournier , Rishikesh Pandey , Michael A. Sapack , Patrick M. Curry , Alan Kersey
IPC: A61B5/00
Abstract: A system and method for determining the presence of cancerous tissue within a tissue cavity is provided. The system includes one or more excitation light sources, a photodetector, a probe, and a system controller. The probe includes an optically transparent probe body configured to fit within the tissue cavity. The system controller is in communication with the excitation light sources, the photodetector, and a memory storing instructions. The instructions when executed cause the system controller to a) control the excitation light sources to produce excitation light beams within the probe body, the excitation light beams operable to produce a response of the tissue to the interrogation and control the photodetector to detect the response and produce signals representative thereof; and b) produce information indicative of a presence of the cancerous tissue using the signals representative of the response.
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公开(公告)号：US20220057263A1
公开(公告)日：2022-02-24
申请号：US17408976
申请日：2021-08-23
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , David Fournier , Gary Root
Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
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公开(公告)号：US20250076201A1
公开(公告)日：2025-03-06
申请号：US18823616
申请日：2024-09-03
Applicant: CytoVeris Inc.
Inventor： Alexandre Dumont , Noel Daignault , David Fournier
IPC: G01N21/64
Abstract: A system and method for analyzing a tissue is provided. The system includes an excitation light unit, a probe, a photodetector, and a system controller. The excitation light unit produces excitation lights. The probe has a flexible cable and a probe head. The flexible cable includes a plurality of light source optical fibers and a light receiving conveyance structure. The probe head receives the excitation lights and produces a distribution of incident light. The photodetector detects the autofluorescence emission, or the diffuse reflectance signal, or both from the tissue and produces signals representative thereof. The photodetector is in communication with the light receiving conveyance structure. Instructions when executed cause the system controller to control the excitation light unit, receive and process the signals from the photodetector, and produce an image representative of the signals produced by the excitation light application.
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公开(公告)号：US11725984B2
公开(公告)日：2023-08-15
申请号：US17408976
申请日：2021-08-23
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , David Fournier , Gary Root
CPC classification number: G01J3/0208 , G01J3/44 , G01N21/65 , G02B26/0833 , G01N2201/12
Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
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