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公开(公告)号：US12038383B2
公开(公告)日：2024-07-16
申请号：US17688776
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
CPC classification number: G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0086 , G01J3/44 , G01N21/6486 , G16H50/20
Abstract: A method and system for identifying tissue types is provided that utilizes Raman scattered light in the high wavenumber region (HWN) of Raman spectrum. The method includes: a) interrogating a tissue specimen with at least one wavelength of light, the wavelength of light operable to produce Raman scattered light in a HWN region of Raman spectrum from the tissue specimen; b) producing signal data representative of the Raman scattering, the signal data relating signal intensity as a function of wavenumber within the HWN region; c) fitting a curve to a portion of the signal data attributable to a HWN peak within the signal data, for a plurality of different HWN peaks; d) determining a plurality of characteristics of each fitted curve; and e) determining a tissue type using the determined characteristics and stored collective data representative of fitted peaks in the HWN region of a plurality of different tissue types.
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12.发明授权公开(公告)号：US11686684B2
公开(公告)日：2023-06-27
申请号：US17513824
申请日：2021-10-28
Applicant: CytoVeris Inc.
Inventor： David Fournier , Rishikesh Pandey
IPC: G01N21/65 , A61B5/00 , G01N33/543 , G01J3/44
CPC classification number: G01N21/658 , A61B5/0075 , G01J3/4412 , G01N33/54346
Abstract: A system and method for assaying high and low abundant biomolecules within a biological fluid sample is provided. The method includes: a) placing a biological fluid sample in contact with a first nanostructure surface; b) interrogating the sample with a light source, the sample in contact with the first nanostructure surface, the interrogation using a SERS technique; c) detecting an enhanced Raman scattering from at least one high abundant biomolecule type and producing first signals representative thereof; d) placing the sample in contact with a second nanostructure surface having a targeting agent that targets a low abundant biomolecule; e) interrogating the sample with the light source using the SERS technique; f) detecting the enhanced Raman scattering from the low abundant biomolecules and producing second signals representative thereof; and g) assaying the biological fluid sample using the first signals and the second signals.
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公开(公告)号：US20220283092A1
公开(公告)日：2022-09-08
申请号：US17688776
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
IPC: G01N21/65
Abstract: A method and system for identifying tissue types is provided that utilizes Raman scattered light in the high wavenumber region (HWN) of Raman spectrum. The method includes: a) interrogating a tissue specimen with at least one wavelength of light, the wavelength of light operable to produce Raman scattered light in a HWN region of Raman spectrum from the tissue specimen; b) producing signal data representative of the Raman scattering, the signal data relating signal intensity as a function of wavenumber within the HWN region; c) fitting a curve to a portion of the signal data attributable to a HWN peak within the signal data, for a plurality of different HWN peaks; d) determining a plurality of characteristics of each fitted curve; and e) determining a tissue type using the determined characteristics and stored collective data representative of fitted peaks in the HWN region of a plurality of different tissue types.
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公开(公告)号：US20210310868A1
公开(公告)日：2021-10-07
申请号：US17222858
申请日：2021-04-05
Applicant: CytoVeris Inc.
Inventor： Gary Root , David Fournier , Rishikesh Pandey
Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.
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公开(公告)号：US11821841B2
公开(公告)日：2023-11-21
申请号：US17688792
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
CPC classification number: G01N21/65 , G01N21/6486 , A61B5/0075
Abstract: A method and system for classifying a tissue specimen is provided. The method includes: a) interrogating a tissue specimen with a first interrogation light; b) detecting first light from the tissue specimen resulting from the interrogation, wherein the first light includes a first scattered light component and a first fluorescence light component, and producing first signals; c) interrogating the tissue specimen with a second interrogation light at a second excitation wavelength, wherein the first and second excitation wavelengths are within about 2 nm of each other; d) detecting second light from the tissue specimen resulting from the interrogation, wherein the second light includes a second scattered light component and a second fluorescence light component, and producing second signals; e) determining a difference between the first and second lights; f) determining a fluorescence spectrum produced by the interrogation of the tissue specimen; and g) classifying the tissue specimen.
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Patent Agency Ranking
公开(公告)号：US20230324300A1
公开(公告)日：2023-10-12
申请号：US18126117
申请日：2023-03-24
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
IPC: G01N21/64
CPC classification number: G01N21/6456 , G01N21/6486
Abstract: A method of and a system for analyzing a tissue sample is provided. The method includes a) imaging a tissue specimen to produce multispectral images of the tissue specimen, the multispectral images including autofluorescence (AF) images and reflectance images acquired at different excitation and emission wavelengths; b) using the multispectral images to produce a plurality of biomolecular barcodes (BBCs) attributable to the tissue specimen; and c) analyzing the tissue specimen to identify a type of the tissue specimen, the analyzing using the plurality of BBCs attributable to the tissue specimen and a plurality of predetermined BBCs based on known tissue types.
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公开(公告)号：US11725984B2
公开(公告)日：2023-08-15
申请号：US17408976
申请日：2021-08-23
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , David Fournier , Gary Root
CPC classification number: G01J3/0208 , G01J3/44 , G01N21/65 , G02B26/0833 , G01N2201/12
Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
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18.发明申请公开(公告)号：US20220099580A1
公开(公告)日：2022-03-31
申请号：US17427391
申请日：2020-01-31
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey
IPC: G01N21/65 , G01N33/58 , G01N33/574
Abstract: A method and system for determining the presence or absence of cancerous cells within subject tissue. The method includes: providing a material that includes a peptide component configurable in a non-binding form when disposed in a neutral pH environment, and in a binding form when disposed in an acidic pH environment, wherein the peptide component is configured to produce a first Raman spectrum when subjected to one or more predetermined wavelengths of light; administering the material to a subject tissue; interrogating the subject tissue with light; sensing the subject tissue for light emitted from the subject tissue, and producing signals representative of the sensed emitted light; analyzing the signals to determine a presence or absence of the first Raman spectrum; and determining the presence or absence of cancerous cells based on the presence or absence of the first Raman spectrum within the sensed light emitted from the subject tissue.
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公开(公告)号：US20220065791A1
公开(公告)日：2022-03-03
申请号：US17464380
申请日：2021-09-01
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey
IPC: G01N21/65 , G01J3/44 , G01N33/483
Abstract: A system for and method of examining a tissue sample using stimulated Raman spectroscopy is provided. The method includes: a) producing a first beam of light at a first wavelength; b) producing a second beam of light at at least a second wavelength, the second wavelength different from the first wavelength; c) combining the first and second beams of light to provide a combined output; d) interrogating a tissue sample with the combined output to produce Raman scattering light, the tissue sample prepared with at least one target molecule having a targeting agent conjugated with a Raman silent dye, the targeting agent configured to bind with at least one biomarker; e) detecting at least a portion of the produced Raman scattering light using a photodetector; and f) producing immunohistological data relating to the tissue sample using photodetector signals representative of the detected Raman scattering light.
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20.发明公开公开(公告)号：US20240035976A1
公开(公告)日：2024-02-01
申请号：US17920640
申请日：2021-04-21
Applicant: CytoVeris Inc.
Inventor： David Fournier , Rishikesh Pandey
IPC: G01N21/64 , G01N21/65 , G01N33/483
CPC classification number: G01N21/6456 , G01N21/65 , G01N21/6402 , G01N33/4833 , G01N2201/06113 , G01N2201/062
Abstract: A method and system of analyzing a resected tissue specimen is provided. The method includes: a) using an imaging system to image a tissue sample with excitation light configured to produce fluorescent emissions from the tissue sample, the imaging producing signals representative of the fluorescent emissions from the sample; b) determining a presence or an absence of at least one suspect tissue region on the tissue sample; c) determining a spatial location of said at least one suspect tissue region determined to be present on the tissue sample; d) using the imaging system to image the suspect tissue region at the determined spatial location with excitation light configured to produce Raman scattering from the sample, the imaging producing signals representative of the Raman scattering from sample; and e) analyzing the determined suspect tissue region using the signals representative of the Raman scattering from the sample.
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