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公开(公告)号：US20240210321A1
公开(公告)日：2024-06-27
申请号：US18567981
申请日：2022-06-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey , Gary Root , Aditya Shirvalkar
IPC: G01N21/64
CPC classification number: G01N21/6486 , G01N21/645 , G01N2021/6417 , G01N2201/1296
Abstract: A method and system of analyzing an ex-vivo tissue sample is provided. The method includes interrogating the tissue sample a plurality of times, each interrogation using at least one excitation light centered on a wavelength distinct from the others, at least one excitation light produces AF emissions from one or more biomolecules associated with the tissue sample, and another is produces diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the AF emissions or diffuse reflectance signals from the tissue sample, producing photodetector signals representative thereof; c) processing the photodetector signals attributable to the AF emissions using a first trained classifier to determine first data sets indicative of biomolecules; d) processing the photodetector signals attributable to the diffuse reflectance signals using a second trained classifier to determine one or more second data sets; and e) determining a type of the tissue sample.
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公开(公告)号：US11441949B2
公开(公告)日：2022-09-13
申请号：US17222858
申请日：2021-04-05
Applicant: CytoVeris Inc.
Inventor： Gary Root , David Fournier , Rishikesh Pandey
Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.
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Patent Agency Ranking
公开(公告)号：US20210310868A1
公开(公告)日：2021-10-07
申请号：US17222858
申请日：2021-04-05
Applicant: CytoVeris Inc.
Inventor： Gary Root , David Fournier , Rishikesh Pandey
Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.
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公开(公告)号：US11725984B2
公开(公告)日：2023-08-15
申请号：US17408976
申请日：2021-08-23
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , David Fournier , Gary Root
CPC classification number: G01J3/0208 , G01J3/44 , G01N21/65 , G02B26/0833 , G01N2201/12
Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
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公开(公告)号：US20230366795A1
公开(公告)日：2023-11-16
申请号：US18196411
申请日：2023-05-11
Applicant: CytoVeris Inc.
Inventor： Morgan McNamara , David Fournier , Noel Diagneault , Michael A. Sapack , Gary Root
CPC classification number: G01N1/36 , A61B90/39 , A61B90/90 , A61B2090/3937 , B01L2200/141 , B01L2300/123 , B01L2300/041 , B01L2300/021 , B01L2300/12
Abstract: An apparatus for holding a tissue specimen during imaging is provided. The tissue specimen has a 3D geometry and a region of interest. The apparatus includes a cover panel and a specimen support structure. The cover panel has upper and bottom panel surfaces and a viewing aperture that extends between the upper and bottom panel surfaces. The specimen support structure is configured to support the tissue specimen in an imaging orientation. The specimen support structure is configured to permit alignment of the tissue specimen ROI with the viewing aperture. The apparatus is configurable in a secured configuration in which the specimen support structure is positionally fixed relative to the cover panel, the tissue specimen ROI is exposed through the viewing aperture for imaging, and the tissue specimen ROI is held motionless relative to the cover panel.
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6.发明公开公开(公告)号：US20230266170A1
公开(公告)日：2023-08-24
申请号：US18017812
申请日：2021-07-26
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , David Fournier , Rishikesh Pandey , Gary Root
CPC classification number: G01J3/44 , G01J3/12 , G01J3/0208 , G01J3/08 , G01J3/10 , G01J3/0218 , G01J2003/102 , G01J2003/1213 , G01N21/65
Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.
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公开(公告)号：US20220057263A1
公开(公告)日：2022-02-24
申请号：US17408976
申请日：2021-08-23
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , David Fournier , Gary Root
Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
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