公开(公告)号：SG2013006333A

公开(公告)日：2014-08-28

申请号：SG2013006333

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

公开(公告)号：AU2002351187A1

公开(公告)日：2003-06-17

申请号：AU2002351187

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  LUCERO MICHAEL ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  C12M1/36 ,  C12N11/16 ,  G01N15/06 ,  C12P19/34

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

公开(公告)号：EP1463796A4

公开(公告)日：2006-03-08

申请号：EP02786834

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  LUCERO MICHAEL ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  C12M1/36 ,  C12N11/16 ,  C12P19/34 ,  G01N15/06

CPC classification number: C12M1/38 ,  B01F13/0059 ,  B01J2219/00337 ,  B01J2219/00353 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50851 ,  B01L2300/0627 ,  B01L2300/123 ,  B01L2400/06 ,  C12Q1/68 ,  C12Q1/6844 ,  C40B60/14 ,  F16K11/20 ,  G01N35/00029 ,  G01N35/0098 ,  G01N2035/00366 ,  Y10T137/2076 ,  Y10T137/2496 ,  Y10T137/86292 ,  Y10T137/87249 ,  Y10T436/2575 ,  C12Q2565/501

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

Abstract translation: 提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。 某些设备具有反应位置阵列以便于高通量分析。 一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经被预先沉积。 一旦将样品引入反应部位，试剂就会停止。 这些装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。

公开(公告)号：EP1796824A4

公开(公告)日：2016-10-19

申请号：EP05766055

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: G01N21/00 ,  B01J3/00 ,  B01J4/00 ,  B01J10/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N15/06 ,  G01N31/22

CPC classification number: B01L7/52 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/004 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0638

公开(公告)号：CA2807591A1

公开(公告)日：2004-10-21

申请号：CA2807591

申请日：2004-04-05

Applicant: FLUIDIGM CORP

Inventor： MCBRIDE LINCOLN ,  LUCERO MICHAEL ,  UNGER MARC ,  NASSEF HANY RAMEZ ,  FACER GEOFFREY

IPC: C12M1/40 ,  B81B3/00 ,  B81B7/04 ,  C12M1/34 ,  C12M1/38 ,  C12P19/34 ,  C12Q1/68 ,  G01N1/00

公开(公告)号：CA2467587A1

公开(公告)日：2003-06-12

申请号：CA2467587

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： WIENECKE ANJA ,  YI YONG ,  FACER GEOFFREY ,  UNGER MARC A ,  LUCERO MICHAEL ,  MIYASHITA-LIN EMILY ,  MANGER IAN DAVID

IPC: G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  C12M1/36 ,  G01N15/06 ,  C12N11/16 ,  C12P19/34

Abstract: A variety of elastomeric-based microfluidic devices and methods for using an d manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagent s have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and ge ne expression analyses.

公开(公告)号：CA2807564C

公开(公告)日：2014-01-28

申请号：CA2807564

申请日：2004-04-05

Applicant: FLUIDIGM CORP

Inventor： MCBRIDE LINCOLN ,  LUCERO MICHAEL ,  UNGER MARC ,  NASSEF HANY RAMEZ ,  FACER GEOFFREY

IPC: B81B3/00 ,  B81B7/04 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/68 ,  C40B30/00 ,  C40B60/00 ,  G01N33/48

Abstract: A microfluidic device, with elastomeric components, and having a flow channel, wherein said flow channel has a plurality of blind flow channels opening into and in fluid communication with the flow channel, each blind flow channel having an aperture portion, a channel portion and a terminus portion, and wherein a region at the terminus of each blind flow channel defines a reaction site. Each blind flow channel is associated with a valve that when closed isolates the reaction site from the flow channel. The valves associated with each of the plurality of blind flow channels in fluid communication with the flow channel are under the control of a common control channel and are coordinately closed or opened.

公开(公告)号：CA2521171C

公开(公告)日：2013-05-28

申请号：CA2521171

申请日：2004-04-05

Applicant: FLUIDIGM CORP

Inventor： MCBRIDE LINCOLN ,  LUCERO MICHAEL ,  UNGER MARC ,  NASSEF HANY RAMEZ ,  FACER GEOFFREY

IPC: B01L3/02 ,  B01L3/00 ,  B01L7/00 ,  B01L99/00 ,  B81B20060101 ,  B81B3/00 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/68 ,  G01N1/10 ,  G01N33/48

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

公开(公告)号：ES2403560T3

公开(公告)日：2013-05-20

申请号：ES02786834

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  LUCERO MICHAEL ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: B01L3/00 ,  B01F13/00 ,  G01N33/53 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00

Abstract: Un dispositivo microfluídico (200), que comprende componentes elastoméricos, y que tiene un canal de flujo (204, 702), en el que dicho canal de flujo tiene una pluralidad de canales de flujo ciego (206) que se abren hacia el interior y están en comunicación de fluidos con el canal de flujo, caracterizándose cada canal de flujo ciego por tener una parte de apertura, una parte de canal, y una parte final, y en el que una región del final de cada canal de flujo ciego define un sitio de reacción (208, 706), en el que cada canal de flujo ciego está asociado con una válvula (212) que cuando se cierra aísla el sitio de reacción del canal de flujo, y caracterizado por que las válvulas asociadas con cada una de la pluralidad de canales de flujo ciego en comunicación de fluidos con el canal de flujo están bajo el control de un canal de control común (210, 712) y se cierran o abren de forma coordinada.

公开(公告)号：CA2807564A1

公开(公告)日：2004-10-21

申请号：CA2807564

申请日：2004-04-05

Applicant: FLUIDIGM CORP

Inventor： MCBRIDE LINCOLN ,  LUCERO MICHAEL ,  UNGER MARC ,  NASSEF HANY RAMEZ ,  FACER GEOFFREY

IPC: B81B3/00 ,  B81B7/04 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/68 ,  C40B30/00 ,  C40B60/00 ,  G01N33/48