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公开(公告)号：AU765111B2
公开(公告)日：2003-09-11
申请号：AU1184000
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Abstract: A protein expression vector characterized by containing a secretory signal nucleotide sequence and, in the 3' downstream side thereof, a Tag nucleotide sequence, a cleavable nucleotide sequence and a cloning site, into which a nucleotide sequence encoding a target protein can be inserted, in this order.
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公开(公告)号：AU755340B2
公开(公告)日：2002-12-12
申请号：AU4396699
申请日：1999-07-02
Applicant: FUSO PHARMACEUTICAL IND
Inventor： KOMINAMI KATSUYA , OKUI AKIRA , MITSUI SHINICHI , YAMAGUCHI NOZOMI
IPC: C07K16/40 , C12N5/20 , C12P21/08 , G01N33/573 , G01N33/68 , C12N15/02 , C12N5/12 , G01N33/577
Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.
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公开(公告)号：CA2350227C
公开(公告)日：2012-07-03
申请号：CA2350227
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N9/50 , A01K67/027 , A61K38/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/57 , C12P21/08 , G01N33/53 , G01N33/573
Abstract: There are provided proteins having amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen using the antibody. The BSSP5 provided by the present invention can be used for treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertropy and for detecting pancreatitis in various tissues including brain, prostate gland, placenta, pancreas and spleen.
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公开(公告)号：CA2350226C
公开(公告)日：2012-04-24
申请号：CA2350226
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Abstract: The present invention relates to a protein expression vector containing a secretory signal nucleotide sequence and, in the 3' downstream side thereof, a Tag nucleotide sequence, a cleavable nucleotide sequence and a cloning site, into which a nucleotide sequence encoding a target protein can be inserted, in this order.
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公开(公告)号：AT438851T
公开(公告)日：2009-08-15
申请号：AT99972675
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI - , MITSUI SHINICHI
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Patent Agency Ranking
公开(公告)号：AU761575B2
公开(公告)日：2003-06-05
申请号：AU1183800
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
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公开(公告)号：CA2348971A1
公开(公告)日：2000-06-02
申请号：CA2348971
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived fr om the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; an d a method for detecting BSSP4 in a specimen by using the antibody.
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公开(公告)号：CA2332131A1
公开(公告)日：2000-01-13
申请号：CA2332131
申请日：1999-07-02
Applicant: FUSO PHARMACEUTICAL IND
Inventor： YAMAGUCHI NOZOMI , KOMINAMI KATSUYA , OKUI AKIRA , MITSUI SHINICHI
IPC: C07K16/40 , C12N5/20 , C12P21/08 , G01N33/573 , G01N33/68 , C12N5/18 , C12N15/02 , C12N5/12 , C12Q1/37 , A61K39/395 , G01N33/577
Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hybridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myelo ma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.
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公开(公告)号：DE69943149D1
公开(公告)日：2011-03-03
申请号：DE69943149
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
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公开(公告)号：CA2350080C
公开(公告)日：2010-04-13
申请号：CA2350080
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N15/52 , A01K67/027 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/64 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/53
Abstract: There are provided proteins having amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.
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