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公开(公告)号：WO0031277A9
公开(公告)日：2000-11-02
申请号：PCT/JP9906472
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND , UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
CPC classification number: C12N9/6424 , A01K2217/05 , A01K2217/075
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived from the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen by using the antibody.
Abstract translation: 具有由SEQ ID NO：2,4,6,8,10,12,14,16,18和20代表的氨基酸序列的蛋白质或具有从上述序列衍生的氨基酸序列的蛋白质通过缺失，取代或添加一个 或其中的几种氨基酸; 编码相同的碱基序列; 具有不同BSSP4表达水平的转基因非人类动物; 抗BSSP4抗体; 以及使用该抗体检测标本中BSSP4的方法。
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公开(公告)号：WO0031257A9
公开(公告)日：2001-04-05
申请号：PCT/JP9906476
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND , UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N1/21 , C12N9/64 , C12N15/12 , C12P21/08 , A01K67/027 , C07K16/40 , C12N5/06 , G01N33/543
CPC classification number: C12N9/6424
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or addition of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSSP6 expression level; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using this antibody.
Abstract translation: 具有由SEQ ID NO：2,4和6表示的氨基酸序列的蛋白质和通过在这些氨基酸序列中缺失，取代或添加一个或几个氨基酸而衍生自这些蛋白质的蛋白质; 编码这些蛋白质的碱基序列; 具有改变的BSSP6表达水平的转基因非人动物; 针对BSSP6的抗体; 以及通过使用该抗体检测标本中的BSSP6的方法。
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公开(公告)号：EP1132479A4
公开(公告)日：2005-08-10
申请号：EP99972690
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
CPC classification number: C07K14/47 , C07K2319/00 , C07K2319/02 , C12N9/6445 , C12N2799/026
Abstract: A protein expression vector characterized by containing a secretory signal nucleic acid sequence and, in the 3'-downstream side thereof, a Tag nucleic acid sequence, a scissile nucleic acid sequence and a cloning site, into which a nucleic sequence encoding a target protein can be inserted, in this order.
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公开(公告)号：EP1132475A4
公开(公告)日：2002-03-27
申请号：EP99972686
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N1/21 , C12N9/64 , C12P21/08 , C12N15/52 , A01K67/027 , C07K16/40 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/53
CPC classification number: C12N9/6424 , A01K2217/05
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.
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公开(公告)号：EP1132477A4
公开(公告)日：2003-05-07
申请号：EP99972687
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
CPC classification number: C12N9/6424 , A01K2217/05 , A01K2217/075
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived from the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen by using the antibody.
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Patent Agency Ranking
公开(公告)号：EP1142993A4
公开(公告)日：2002-08-07
申请号：EP99972675
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: A61K38/00 , C12N1/21 , C12N9/64 , C12N15/57 , C12P21/08 , G01N33/573 , C12N9/50 , A01K67/027 , C07K16/40 , G01N33/53
CPC classification number: C12N9/6424 , A01K2217/075 , A61K38/00 , G01N33/573
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 thus provided is useable in treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertrophy and detecting pancreatitis in various tissues including brain, prostate gland, placenta, testis, pancreas and spleen.
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公开(公告)号：CA2350227A1
公开(公告)日：2000-06-02
申请号：CA2350227
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: A61K38/00 , C12N1/21 , C12N9/64 , C12N15/57 , C12P21/08 , G01N33/573 , C12N9/50 , A01K67/027 , C07K16/40 , G01N33/53
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and bas e sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 th us provided is useable in treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertrophy and detecting pancreatitis in various tissues includin g brain, prostate gland, placenta, testis, pancreas and spleen.
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公开(公告)号：EP1132473A4
公开(公告)日：2002-06-12
申请号：EP99972681
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N1/21 , C12N9/64 , C12N15/12 , C12P21/08 , A01K67/027 , C07K16/40 , C12N5/06 , G01N33/543
CPC classification number: C12N9/6424
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or addition of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSSP6 expression level; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using this antibody.
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9.发明公开SERINE PROTEASE-SPECIFIC MONOCLONAL ANTIBODY AND UTILIZATION THEREOF 有权丝氨酸蛋白酶SPZIFISCHER MONIKLONALER抗体及其用途
公开(公告)号：EP1092767A4
公开(公告)日：2001-10-24
申请号：EP99926899
申请日：1999-07-02
Applicant: FUSO PHARMACEUTICAL IND
Inventor： KOMINAMI KATSUYA , OKUI AKIRA , MITSUI SHINICHI , YAMAGUCHI NOZOMI
IPC: C07K16/40 , C12N5/20 , C12P21/08 , G01N33/573 , G01N33/68 , C12N15/02 , A61K39/395 , C12N5/12 , G01N33/577
CPC classification number: C07K16/40 , G01N33/573 , G01N33/6896 , Y10S435/96 , Y10S436/811
Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hybridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.
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公开(公告)号：CA2332131C
公开(公告)日：2007-05-15
申请号：CA2332131
申请日：1999-07-02
Applicant: FUSO PHARMACEUTICAL IND
Inventor： YAMAGUCHI NOZOMI , KOMINAMI KATSUYA , OKUI AKIRA , MITSUI SHINICHI
IPC: C12P21/08 , A61K39/395 , C07K16/40 , C12N5/12 , C12N5/18 , C12N5/20 , C12N15/02 , C12Q1/37 , G01N33/573 , G01N33/577 , G01N33/68
Abstract: The present invention is directed to a monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular strain 2B2-6 and strain S2E5, showing stable proliferation ability. These hybridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody that binds specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.
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