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公开(公告)号：WO0031277A9
公开(公告)日：2000-11-02
申请号：PCT/JP9906472
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND , UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
CPC classification number: C12N9/6424 , A01K2217/05 , A01K2217/075
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived from the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen by using the antibody.
Abstract translation: 具有由SEQ ID NO：2,4,6,8,10,12,14,16,18和20代表的氨基酸序列的蛋白质或具有从上述序列衍生的氨基酸序列的蛋白质通过缺失，取代或添加一个 或其中的几种氨基酸; 编码相同的碱基序列; 具有不同BSSP4表达水平的转基因非人类动物; 抗BSSP4抗体; 以及使用该抗体检测标本中BSSP4的方法。
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公开(公告)号：WO0031257A9
公开(公告)日：2001-04-05
申请号：PCT/JP9906476
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND , UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N1/21 , C12N9/64 , C12N15/12 , C12P21/08 , A01K67/027 , C07K16/40 , C12N5/06 , G01N33/543
CPC classification number: C12N9/6424
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or addition of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSSP6 expression level; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using this antibody.
Abstract translation: 具有由SEQ ID NO：2,4和6表示的氨基酸序列的蛋白质和通过在这些氨基酸序列中缺失，取代或添加一个或几个氨基酸而衍生自这些蛋白质的蛋白质; 编码这些蛋白质的碱基序列; 具有改变的BSSP6表达水平的转基因非人动物; 针对BSSP6的抗体; 以及通过使用该抗体检测标本中的BSSP6的方法。
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公开(公告)号：EP1132479A4
公开(公告)日：2005-08-10
申请号：EP99972690
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
CPC classification number: C07K14/47 , C07K2319/00 , C07K2319/02 , C12N9/6445 , C12N2799/026
Abstract: A protein expression vector characterized by containing a secretory signal nucleic acid sequence and, in the 3'-downstream side thereof, a Tag nucleic acid sequence, a scissile nucleic acid sequence and a cloning site, into which a nucleic sequence encoding a target protein can be inserted, in this order.
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公开(公告)号：EP1132475A4
公开(公告)日：2002-03-27
申请号：EP99972686
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N1/21 , C12N9/64 , C12P21/08 , C12N15/52 , A01K67/027 , C07K16/40 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/53
CPC classification number: C12N9/6424 , A01K2217/05
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.
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公开(公告)号：EP1132473A4
公开(公告)日：2002-06-12
申请号：EP99972681
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: C12N1/21 , C12N9/64 , C12N15/12 , C12P21/08 , A01K67/027 , C07K16/40 , C12N5/06 , G01N33/543
CPC classification number: C12N9/6424
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or addition of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSSP6 expression level; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using this antibody.
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Patent Agency Ranking
公开(公告)号：EP1132477A4
公开(公告)日：2003-05-07
申请号：EP99972687
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
CPC classification number: C12N9/6424 , A01K2217/05 , A01K2217/075
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived from the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen by using the antibody.
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公开(公告)号：EP1142993A4
公开(公告)日：2002-08-07
申请号：EP99972675
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: A61K38/00 , C12N1/21 , C12N9/64 , C12N15/57 , C12P21/08 , G01N33/573 , C12N9/50 , A01K67/027 , C07K16/40 , G01N33/53
CPC classification number: C12N9/6424 , A01K2217/075 , A61K38/00 , G01N33/573
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 thus provided is useable in treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertrophy and detecting pancreatitis in various tissues including brain, prostate gland, placenta, testis, pancreas and spleen.
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公开(公告)号：AU765111B2
公开(公告)日：2003-09-11
申请号：AU1184000
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
Abstract: A protein expression vector characterized by containing a secretory signal nucleotide sequence and, in the 3' downstream side thereof, a Tag nucleotide sequence, a cleavable nucleotide sequence and a cloning site, into which a nucleotide sequence encoding a target protein can be inserted, in this order.
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公开(公告)号：CA2350227A1
公开(公告)日：2000-06-02
申请号：CA2350227
申请日：1999-11-19
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , OKUI AKIRA , KOMINAMI KATSUYA , YAMAGUCHI NOZOMI , MITSUI SHINICHI
IPC: A61K38/00 , C12N1/21 , C12N9/64 , C12N15/57 , C12P21/08 , G01N33/573 , C12N9/50 , A01K67/027 , C07K16/40 , G01N33/53
Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and bas e sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 th us provided is useable in treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertrophy and detecting pancreatitis in various tissues includin g brain, prostate gland, placenta, testis, pancreas and spleen.
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公开(公告)号：JP2000002703A
公开(公告)日：2000-01-07
申请号：JP16828598
申请日：1998-06-16
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , KISHI YUICHIRO , KUNITO KAZUYA , HIROOKA YUMI
IPC: G01N33/50 , A61K9/16 , A61K39/395 , C07K16/18 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/543
Abstract: PROBLEM TO BE SOLVED: To judge the diagnosis and critical degree of renal disease by bringing a second antibody having a labeled molecule connected thereto into contact with a biological sample and a subject having a first antibody brought into contact with the surface of a solid granule, and detecting the labeled molecule connected to a complement control factor. SOLUTION: With respect to urine and serum of a normal person and a renal disease patient, MCP quantity (membrane cofactor protein) is measured. A magnetic bead having a monoclonal antibody 177, a subject and a POD labeled monoclonal antibody M160 are reacted to focus and fix the bead by the magnet, and the supernatant is disposed. After washing, a substrate solution is added to further react them, and the bead is focused and fixed by the magnet, and the supernatant is collected to measure the absorbance. The serum MCP value is measured by use of the monoclonal antibody M160 and also by use of the POD labeled monoclonal antibody M160 as the detecting antibody. As a result of the measurement, the MCP values in urine and serum are distributed in high level in the renal disease patient, compared with the normal person, and also high in a more critical patient.
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