公开(公告)号：CA2900920C

公开(公告)日：2018-08-21

申请号：CA2900920

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO ,  THE CHEMO SERO THERAPEUTIC RES INSTITUTE

Inventor： MACHIDA KAZUYA ,  TOKUMOTO SEIJI ,  KAMINAKA KAZUYOSHI ,  ISHIKAWA YUJI

IPC: A61K47/18 ,  A61K9/70 ,  A61K39/12 ,  A61K47/12 ,  A61P31/14

Abstract: Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.

公开(公告)号：AU2014217108B2

公开(公告)日：2017-06-15

申请号：AU2014217108

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MACHIDA KAZUYA ,  TOKUMOTO SEIJI ,  KAMINAKA KAZUYOSHI ,  ISHIKAWA YUJI

IPC: A61K47/18 ,  A61K9/70 ,  A61K39/12 ,  A61K47/12 ,  A61P31/14

Abstract: Disclosed is a microneedle coating composition which includes a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, the number of moles of the acid relative to 1 mol of the basic amino acid being in the range of more than 1/(N+1) to less than 2 when N is the valence of the acid.

公开(公告)号：ES2834200T3

公开(公告)日：2021-06-16

申请号：ES12750249

申请日：2012-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MORIMOTO KUMI ,  TOKUMOTO SEIJI

IPC: A61K39/39 ,  A61K9/02 ,  A61K9/06 ,  A61K9/14 ,  A61K9/70 ,  A61K39/00

Abstract: Un adyuvante que comprende uno o más seleccionados del grupo que consiste en glicerina y propilenglicol que son alcoholes polihídricos para su uso en la mejora de la actividad inmunitaria cuando se administra mediante aplicación transdérmica o transmucosa después de la administración de antígeno, en el que el adyuvante está contenido al 85-100 % en peso en una preparación farmacéutica, en el que el uso comprende la administración del antígeno por inyección subcutánea o intradérmica, administración transmucosa o transdérmica del antígeno o administración del antígeno con microagujas antes de aplicar el adyuvante.

公开(公告)号：ES2744454T3

公开(公告)日：2020-02-25

申请号：ES14858381

申请日：2014-10-30

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MACHIDA KAZUYA ,  KUROKAWA NAO ,  NAMIKI RIE

IPC: A61K39/39 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K9/70 ,  A61K39/00 ,  A61K47/10

Abstract: Una composición de adyuvante para su uso en la potenciación de la respuesta inmunológica, que comprende alcohol laurílico y propilenglicol, y que comprende además glicerol en la que los contenidos del alcohol laurílico, el propilenglicol, y el glicerol son de un 0,5 a un 25 % en masa, de un 8,0 a un 90 % en masa, y de un 1,0 a un 90 % en masa, con respecto a la masa total de la composición de adyuvante, respectivamente, en la que el alcohol laurílico está disuelto, y en la que la composición se usa para administración transdérmica o transmucosa.

公开(公告)号：CA2790923C

公开(公告)日：2017-10-31

申请号：CA2790923

申请日：2011-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MATSUDO TOSHIYUKI ,  NISHIMURA SHINPEI ,  TOKUMOTO SEIJI ,  MORIMOTO KUMI

IPC: A61M37/00

Abstract: A micro-needle device has a base, micro-needles, which are established on this base, and a physiologically active composition, which is adhered to the micro-needles and/or the base. The physiologically active composition contains a physiologically active substance and at least one type of polyhydric alcohol, selected from glycerin, ethylene glycol, propylene glycol and 1, 3-butylene glycol. The micro-needle device is effectively free of water.

公开(公告)号：SG11201702779PA

公开(公告)日：2017-05-30

申请号：SG11201702779P

申请日：2015-10-19

Applicant: HISAMITSU PHARMACEUTICAL CO ,  ASKA PHARM CO LTD

Inventor： NISHIMURA SHINPEI ,  TOKUMOTO SEIJI ,  ITO TAKESHI ,  ASADA HAJIME

IPC: A61K38/24 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61P5/24 ,  A61P15/08

Abstract: The present invention provides a microneedles device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.

公开(公告)号：AT532553T

公开(公告)日：2011-11-15

申请号：AT07713903

申请日：2007-02-07

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MATSUDO TOSHIYUKI ,  KUWAHARA TETSUJI

IPC: A61M37/00 ,  A61M5/30 ,  A61N1/30

Abstract: It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).

公开(公告)号：ES2895764T3

公开(公告)日：2022-02-22

申请号：ES17888272

申请日：2017-12-25

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： HORI RYOTA ,  KOGURE TOSHIHIRO ,  TOKUMOTO SEIJI ,  NISHIMURA SHINPEI

IPC: A61K31/4174 ,  A61K9/00 ,  A61K47/18 ,  A61K47/20 ,  A61L31/08 ,  A61M37/00 ,  A61P25/20

Abstract: Un dispositivo de microagujas que comprende: un sustrato; microagujas dispuestas sobre el sustrato; y un recubrimiento formado sobre las microagujas, en donde el recubrimiento comprende dexmedetomidina o una sal farmacéuticamente aceptable de la misma e isoproterenol o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：AU2014217108A1

公开(公告)日：2015-08-27

申请号：AU2014217108

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO ,  CHEMO SERO THERAPEUT RES INST

Inventor： MACHIDA KAZUYA ,  TOKUMOTO SEIJI ,  KAMINAKA KAZUYOSHI ,  ISHIKAWA YUJI

IPC: A61K47/18 ,  A61K9/70 ,  A61K39/12 ,  A61K47/12 ,  A61P31/14

Abstract: Disclosed is a microneedle coating composition which includes a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, the number of moles of the acid relative to 1 mol of the basic amino acid being in the range of more than 1/(N+1) to less than 2 when N is the valence of the acid.

公开(公告)号：CA2900920A1

公开(公告)日：2014-08-21

申请号：CA2900920

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO ,  CHEMO SERO THERAPEUT RES INST

Inventor： MACHIDA KAZUYA ,  TOKUMOTO SEIJI ,  KAMINAKA KAZUYOSHI ,  ISHIKAWA YUJI

IPC: A61K47/18 ,  A61K9/70 ,  A61K39/12 ,  A61K47/12 ,  A61P31/14

Abstract: Disclosed is a microneedle coating composition which includes a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, the number of moles of the acid relative to 1 mol of the basic amino acid being in the range of more than 1/(N+1) to less than 2 when N is the valence of the acid.